Effect of dephasing on the current statistics of mesoscopic devices

We investigate the effects of dephasing on the current statistics of mesoscopic conductors with a recently developed statistical model, focusing in particular on mesoscopic cavities and Aharonov-Bohm rings. For such devices, we analyze the influence of an arbitrary degree of decoherence on the cumulants of the current. We recover known results for the limiting cases of fully coherent and totally incoherent transport and are able to obtain detailed information on the intermediate regime of partial coherence for a varying number of open channels. We show that dephasing affects the average current, shot noise, and higher order cumulants in a quantitatively and qualitatively similar way, and that consequently shot noise or higher order cumulants of the current do not provide information on decoherence additional or complementary to what can be already obtained from the average current.Comment: 4 pages, 4 figure

Statistical model of dephasing in mesoscopic devices introduced in the scattering matrix formalism

We propose a phenomenological model of dephasing in mesoscopic transport, based on the introduction of random phase fluctuations in the computation of the scattering matrix of the system. A Monte Carlo averaging procedure allows us to extract electrical and microscopic device properties. We show that, in this picture, scattering matrix properties enforced by current conservation and time reversal invariance still hold. In order to assess the validity of the proposed approach, we present simulations of conductance and magnetoconductance of Aharonov-Bohm rings that reproduce the behavior observed in experiments, in particular as far as aspects related to decoherence are concerned.Comment: 6 pages, 6 figure

Wireless ultrasound-guided vacuum-assisted breast biopsy: Experience in clinical practice at European Institute of Oncology

In the last few years, ultrasound-guided vacuum-assisted breast biopsy (US-VABB) has replaced surgical biopsy due to higher diagnostic accuracy and lower patient discomfort, and, at present, an even greater possibility is represented by the new wireless ultrasound-guided VAB device (Wi-UVAB). The purpose of our study is to determine the diagnostic accuracy of this new device in a sizeable representative number of patients. From January 2014 to June 2018, 168 biopsies were performed in our institution using the new Wi-UVAB device. We analyzed sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of biopsies obtained with the new device using surgical results as reference point, following patients for at least one year. In our cohort, we obtained a complete sensitivity of 97.5%, an absolute sensitivity of 94.3%, a complete specificity of 98%, and an absolute specificity of 98%. The positive predictive value of the procedure was 97.5% while the negative predictive value was 98%. The diagnostic accuracy was 98%. The Wi-UVAB is a safe procedure with high diagnostic accuracy, comparable to that of the traditional vacuum-assisted breast biopsy and even higher than that of core needle biopsy (CNB). Moreover, the Wi-UVAB is easy to use and shows low costs as core needle biopsy (CNB)

Melatonin finely tunes proliferation and senescence in hematopoietic stem cells

Human hematopoietic stem/progenitor cells (HSPCs) are pluripotent cells that gradually lose their self-renewal and regenerative potential, to give rise to mature cells of the hematopoietic system by differentiation. HSPC infusion is used to restore hematopoietic function in patients with a variety of onco-hematologic and immune-mediated disorders. The functionality of these cells is therefore of great importance to ensure the homeostasis of the hematopoietic system. Melatonin plays an important role as immunomodulatory and oncostatic hormone. In the present manuscript, we aimed at evaluating the activity of melatonin in modulating HSPC senescence, in the attempt to improve their hemopoietic regenerative potential. We exposed HSPCs to melatonin, in different conditions, and then analyzed the expression of genes regulating cell cycle and cell senescence. Moreover, we assessed cell senescence by β-galactosidase and telomerase activity. Our results showed the ability of melatonin to counteract HSPC senescence, thus paving the way for enhanced efficiency in their clinical application

Biomarkers of inflammation and breast cancer risk: A case-control study nested in the EPIC-Varese cohort

Abstract Breast cancer (BC) is the leading cause of cancer death in women. Adipokines, and other inflammation molecules linked to adiposity, are suspected to be involved in breast carcinogenesis, however prospective findings are inconclusive. In a prospective nested case-control study within the EPIC-Varese cohort, we used conditional logistic regression to estimate rate ratios (RRs) for BC, with 95% confidence intervals (CI), in relation to plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6, leptin, and adiponectin, controlling for BC risk factors. After a median 14.9 years, 351 BC cases were identified and matched to 351 controls. No marker was significantly associated with BC risk overall. Significant interactions between menopausal status and CRP, leptin, and adiponectin were found. Among postmenopausal women, high CRP was significantly associated with increased BC risk, and high adiponectin with significantly reduced risk. Among premenopausal women, high TNF-α was associated with significantly increased risk, and high leptin with reduced risk; interleukin-6 was associated with increased risk only in a continuous model. These findings constitute further evidence that inflammation plays a role in breast cancer. Interventions to lower CRP, TNF-α, and interleukin-6 and increase adiponectin levels may contribute to preventing BC

Rashba spin precession in quantum Hall edge channels

Quasi--one dimensional edge channels are formed at the boundary of a two-dimensional electron system subject to a strong perpendicular magnetic field. We consider the effect of Rashba spin--orbit coupling, induced by structural inversion asymmetry, on their electronic and transport properties. Both our analytical and numerical results show that spin--split quantum--Hall edge channels exhibit properties analogous to that of Rashba--split quantum wires. Suppressed backscattering and a long spin life time render these edge channels an ideal system for observing voltage--controlled spin precession. Based on the latter, we propose a magnet--less spin--dependent electron interferometer.Comment: 7 pages, 6 figure

Design and synthesis of novel DNA binders

In this context, molecular recognition of DNA by polycyclic heterocycles having a planar structure bearing appropriate side chains have been widely investigated. In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, we designed and synthetized several templates as potential substrate in drug design