How the global structure of protein interaction networks evolves

Two processes can influence the evolution of protein interaction networks: addition and elimination of interactions between proteins, and gene duplications increasing the number of proteins and interactions. The rates of these processes can be estimated from available Saccharomyces cerevisiae genome data and are sufficiently high to affect network structure on short time scales. For instance, more than 100 interactions may be added to the yeast network every million years, a substantial fraction of which adds previously unconnected proteins to the network. Highly connected proteins show a greater rate of interaction turnover than proteins with few interactions. From these observations one can explain ? without natural selection on global network structure ? the evolutionary sustenance of the most prominent network feature, the distribution of the frequency P(d) of proteins with d neighbors, which is a broad-tailed distribution. This distribution is independent of the experimental approach providing nformation on network structure

Inversion of 2 wavelength Lidar data for cloud properties

The inversion of the lidar equation to derive quantitative properties of the atmosphere has continued to present considerable difficulty. The results of a study in which Klett's procedure was utilized for the analysis of cloud backscatter measurements made simulataneously at two ruby lidar wavelengths (694nm,347nmm) are presented. With one lidar system a cloud is probed at the two wavelength and the backscatter measured simulataneously by separate receivers. As a result two sigma profiles which should differ only because the wavlength dependence of the scattering. Experimental data presented to demonstrate the effects and the implications of the applications of the inversion method will be discussed

Many-body localization beyond eigenstates in all dimensions

Isolated quantum systems with quenched randomness exhibit many-body localization (MBL), wherein they do not reach local thermal equilibrium even when highly excited above their ground states. It is widely believed that individual eigenstates capture this breakdown of thermalization at finite size. We show that this belief is false in general and that a MBL system can exhibit the eigenstate properties of a thermalizing system. We propose that localized approximately conserved operators (l$^*$-bits) underlie localization in such systems. In dimensions $d>1$, we further argue that the existing MBL phenomenology is unstable to boundary effects and gives way to l$^*$-bits. Physical consequences of l$^*$-bits include the possibility of an eigenstate phase transition within the MBL phase unrelated to the dynamical transition in $d=1$ and thermal eigenstates at all parameters in $d>1$. Near-term experiments in ultra-cold atomic systems and numerics can probe the dynamics generated by boundary layers and emergence of l$^*$-bits.Comment: 12 pages, 5 figure