Phytochemical Compounds and Protection from Cardiovascular Diseasesa. A State of the Art

Cardiovascular diseases represent a worldwide relevant socioeconomical problem. Cardiovascular disease prevention relies also on lifestyle changes, including dietary habits. The cardioprotective effects of several foods and dietary supplements in both animal models and in humans have been explored. It was found that beneficial effects are mainly dependent on antioxidant and anti-inflammatory properties, also involving modulation of mitochondrial function. Resveratrol is one of the most studied phytochemical compounds and it is provided with several benefits in cardiovascular diseases as well as in other pathological conditions (such as cancer). Other relevant compounds are Brassica oleracea, curcumin, and berberine, and they all exert beneficial effects in several diseases. In the attempt to provide a comprehensive reference tool for both researchers and clinicians, we summarized in the present paper the existing literature on both preclinical and clinical cardioprotective effects of each mentioned phytochemical. We structured the discussion of each compound by analyzing, first, its cellular molecular targets of action, subsequently focusing on results from applications in both ex vivo and in vivo models, finally discussing the relevance of the compound in the context of human diseases

A methodological comparison between energy and environmental performance evaluation

The European Union is working on strategies in order to increase the energy efficiency of buildings. A useful solution is to identify the energy performance of buildings through the Energy Performance Certificate (EPC), as it provides information for the comparison of buildings with different architectural typology, shape, design technology and geographic location. However, this tool does not assess the real energy consumption of the building and does not always take into account its impact on the environment. In this work, two different types of analysis were carried out: one based only on the energy efficiency and the other one based on the environmental impact. Those analyses were applied on a standard building, set in three different Italian locations, with the purpose of obtaining cross-related information. After the evaluation of the results, interventions on some parameters (walls insulation, windows frame, filler gas in the insulated glazing) have been identified in order to improve the energy behavior of the building with an acceptable environmental impact. The aim of this paper is to propose a methodology that integrates the EPC with green building rating systems, leading to a more conscious choice of retrofit interventions as a compromise between energy performances and environmental impact

Case study on economic return on investments for safety and emergency lighting in road tunnels

While planning a double-hole road tunnel with a length higher than one km, it is important to pay attention to the safety factor if an accident occurs. If there is a power outage, in order to avoid critical situations that could jeopardize the safety of the people present (facilitating the stream coming out from the tunnel and the arrival of the emergency personnel), it is really important to guarantee uninterrupted lighting of roadways, mandatory emergency lay-bys, and ways of escape. Uninterrupted service of the lighting systems supply must be guaranteed, in accordance with the current regulations, through the exertion of UPS (Uninterruptible Power Supply) and power units. During tunnel construction, such devices represent a cost that must be amortized. In this case study, which takes into consideration a section of a road tunnel characterized by emergency lay-bys and ways of escape, emergency and security lighting were planned and installation and management costs were evaluated. The goal of this research was the creation of a cash flow thanks to the energy generated by photovoltaic panels, in a way that the service life of the system (25 years) coincided with the amortization of the costs of the backup electrical equipment installation (complying with the regulations). The possibility of over-dimensioning the UPS and providing it with a proper photovoltaic panel surface (235 kWp) to generate and exchange electric energy with the grid was taken into consideration

Computational Fluid Dynamic Modelling of Thermal Periodic Stabilized Regime in Passive Buildings

The periodic stabilized regime is the condition where the temperature of each point of a certain environment varies following a periodic law. This phenomenon occurs in many practical applications, such as passive or ancient buildings not equipped with Heating, Ventilating and Air Conditioning HVAC systems and located in latitudes where the temperature greatly varies with Earth's daily cycles. Despite that, the study of transient phenomena is often simplified, i.e., considering negligible the thermal response of the indoor microclimate. An exact solution to enclosures whose microclimate is free to evolve under a periodic stabilized regime does not exist nowadays, also from an analytical point of view. The aim of this study is to parametrically analyze the thermal variations inside a room when a transient periodic temperature is applied on one side. The phenomenon has been numerically studied through Computational Fluid Dynamics (CFD) and analytically validated using a function that reproduces the daily variation of the outdoor temperature. The results of this research would lay the groundwork to develop analytical correlations to solve and predict the thermal behavior of environments subject to a periodic stabilized regime