4 research outputs found
Ipilimumab induced digital vasculitis
Abstract
Background
Immune check point inhibitors (ICIs) have emerged as a new therapeutic paradigm for a variety of malignancies including metastatic melanoma. As the use of ICIs expand, immune-mediated adverse events are becoming a common occurrence.
Case presentation
We describe the first reported patient with small vessel vasculitis, manifested by digital ischemia, following treatment with high dose Ipilimumab for resected stage IIIB/C melanoma. This patient received high dose steroids, five-day intravenous (IV) Epoprostenol protocol, botulinum toxin injections, and Rituximab 375Â mg/m2 weekly for four cycles. With this treatment regimen, the digital ischemia did not progress proximally, but she did require multiple distal digit amputations about six months after the onset of her symptoms.
Conclusions
Prompt identification and management of immune related adverse events (IRAEs) are critical to optimal patient management. This patientâs vasculitis did not reverse, but was likely halted and stabilized with multiple immunosuppressive medications.https://deepblue.lib.umich.edu/bitstream/2027.42/142381/1/40425_2018_Article_321.pd
Access and costârelated nonâadherence to prescription medications among lupus cases and controls: the Michigan Lupus Epidemiology & Surveillance (MILES) Program
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/171010/1/acr24397.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/171010/2/acr24397_am.pd
Access and cost-related non-adherence to prescription medications among lupus cases and controls: the Michigan Lupus Epidemiology & Surveillance (MILES) Program
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/171010/1/acr24397.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/171010/2/acr24397_am.pd
Access and CostâRelated Nonadherence to Prescription Medications Among Lupus Patients and Controls: The Michigan Lupus Epidemiology and Surveillance Program
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/171010/1/acr24397.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/171010/2/acr24397_am.pd