80 research outputs found
FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF BISOPROLOL FUMARATE
ABSTRACT: Bisoprolol Fumarate is an antihypertensive agent used in the management of hypertension and prophylaxis treatment of angina pectoris and heart failure. Present work aimed at preparing quick onset of action which is beneficial in hypertension, aiding in the enhancement of bioavailabity and is very convenient for administration without the problem of swallowing and using water. The film were prepared by using polymers such as hydroxypropyl methyl cellulose (HPMC) and Maltodextrin, plasticizer such as PEG 400, by a solvent casting method. They were evaluated for physical characteristics such as thickness, uniformity of weight, folding endurance, drug content, surface ph, percentage elongation and tensile strength and give satisfactory results. The formulations were subjected to disintegration, in-vitro drug release test. The in vitro disintegration time of the optimized batch F4 was found to be 20 sec. The optimized batch was found to be stable for 1 month under specified stability conditions
On the routines of wild-type silk fibroin processing toward silk-inspired materials: a review
For years, silk fibroin of a domestic silkworm, Bombyx mori, has been recognized as a valuable material and extensively used. In the last decades, new application fields are emerging for this versatile material. Those final, specific applications of silk dictate the way it has been processed in industry and research. This review focuses on the description of various approaches for silk downstream processing in a laboratory scale, that fall within several categories. The detailed description of workflow possibilities from the naturally found material to a finally formulated product is presented. Considerable attention is given to (bio-) chemical approaches of silk fibroin transformation, particularly, to its enzyme-driven modifications. The focus of the current literature survey is exclusively on the methods applied in research and not industry
A Spider‐Capture‐Silk‐Like Fiber with Extremely High‐Volume Directional Water Collection
Silk sericin and its applications: A review
323-329Silk consists of two types of proteins, silk fibroin and sericin. Sericin contributes about 20-30 per cent of total cocoon weight. It is characterized by its high content of serine and 18 amino acids, including essential amino acids. There are different methods of isolation of sericin from silk thread. Solubility, molecular weight, and gelling properties of sericin depend on the method of isolation. It has wide applications in pharmaceuticals and cosmetics such as, wound healing, bioadhesive moisturizing, antiwrinkle and antiaging
TNF-α Blocker Effect of Naringenin-Loaded Sericin Microparticles that Are Potentially Useful in the Treatment of Psoriasis
This study aims to evaluate the effect of combined use of the racemic flavanone Naringenin (NRG) and the protein sericin as TNF-α blockers. Sericin (SMs) and (R/S) NRG-loaded Sericin (SNRGMs) microparticles were prepared by spray-drying, characterized in terms of morphology and particle size distribution, and encapsulation efficiency was determined. Concerning morphology and particle size distribution of microparticles, results indicated that they were not affected by the presence of NRG. The encapsulation efficiency was almost quantitative (93%), thus proving that sericin can be advantageously loaded with (R/S) NRG. Biological evaluation of (R/S) NRG, SMs and SNRGMs was then performed in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (hPBMC). SNRGMs resulted cytotoxic at the higher dose used (200 μg/mL) and the effect was greater than (R/S) NRG alone. Moreover, even if sericin alone was not effective in suppressing LPS-induced serum TNF-α levels, SNRGMs loaded with 9.3% of (R/S) NRG were significantly more potent than (R/S) NRG alone. In summary, this study provides the proof of concept that sericin-based microspheres loaded with TNF-α-blockers could contribute to the down regulation of the cytokine and represents the starting point for the development of new topical formulations for the treatment of middle-stage psoriasis
Production and properties of electrosprayed sericin nanopowder
Sericin is a proteinous substrate that envelops fibroin (silk) fiber, and its recovery provides significant economical and social benefits. Sericin is an antibacterial agent that resists oxidation and absorbs moisture and UV light. In powder form, sericin has a wide range of applications in food, cosmetics and drug delivery. Asides from other techniques of producing powder, such as precipitation and spray drying, electrospraying can yield solid nanoparticles, particularly in the submicron range. Here, we report the production of sericin nanopowder by electrospraying. Sericin sponge was recovered from Bombyx mori cocoons through a high-temperature, high-pressure process, followed by centrifugation and freeze drying of the sericin solution. The electrospraying solution was prepared by dissolving the sericin sponge in dimethyl sulfoxide. We demonstrate that electrospraying is capable of producing sericin nanopowder with an average particle size of 25 nm, which is by far smaller than the particles produced by other techniques. The electrosprayed sericin nanopowder consists of small crystallites and exhibits a high moisture absorbance
Gelation Behaviors and Mechanism of Silk Fibroin According to the Addition of Nitrate Salts
Effects of Silk Degumming Process on Physicochemical, Tensile, and Optical Properties of Regenerated Silk Fibroin
Moisturizing efficiency of silk protein hydrolysate: Silk fibroin
115-121A biomimetic approach of composition and natural function of natural moisturizing factor (NMF) with the amino acid content of silk fibroin was advantageously used to reconstruct the skin moisturizing system. The isolation of silk hydrolysate with water and sodium chloride treatment was complete in one hour. Lithium ion from LiBr effectively penetrated crystal domains of fibroin and gave desired solubility. Silk fibroin from Bombyx mori cocoons was non-allergic and biocompatible in skin and rabbit eye tests. The concentration dependent moisturizing efficacy of fibroin (1-5% w/v) in solution and cream form has been demonstrated by TEWL in vitro and in volunteers. As compared to dry and normal skin the fibroin containing cream revealed increased substantivity. The increased hydroxproline content was responsible for retaining higher moisture in the skin. This in turn maintained the skin in soft and supple state. The significant drop in impedance was observed within 1 hr of the application of fibroin and the effect was sustained for more than 6 hrs. Thus, increased hydration level in stratum corneum was achieved by fibroin treatment. The SEM of fibroin treated skin replicas showed a desired attribute of soft, smooth skin texture and improved flexibility. The increased state of hydration caused interdigitating of cell edges as evident in microphotographs. The rapid and sustained moisturizing efficiency observed with silk fibroin was well substantiated by the results of skin substantivity and impedance tests
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