Building Real-Time Collaborative Applications with a Federated Architecture

Real-time collaboration is being offered by multiple libraries and APIs (Google Drive Real-time API, Microsoft Real-Time Communications API, TogetherJS, ShareJS), rapidly becoming a mainstream option for webservices developers. However, they are offered as centralised services running in a single server, regardless if they are free/open source or proprietary software. After re-engineering Apache Wave (former Google Wave), we can now provide the first decentralised and federated free/open source alternative. The new API allows to develop new real-time collaborative web applications in both JavaScript and Java environments

Uso de situaciones problemáticas abiertas en las clases prácticas de física : Una innovación

Los fracasos en el examen final y el alto porcentaje de repitentes de la asignatura Física del primer año de las carreras de Ingeniería, requieren una revisión del desarrollo de las clases. En la actualidad la asignatura se instrumenta esencialmente en: clases teóricas, para abordar los conceptos básicos, clases prácticas en las que se resuelven ejercicios y clases de laboratorio en donde se verifican principios y/o leyes desarrolladas en las clases teóricas. Tanto en las clases prácticas como en las de laboratorio, los estudiantes cuentan con guías que contienen ejercicios y problemas cerrados. Con el objeto aportar una solución para palear el problema planteado, en este trabajo se describe el desarrollo de un proyecto de innovación en las clases prácticas basado en la inclusión de situaciones problemáticas abiertas y las apreciaciones realizadas por los estudiantes de la nueva propuest

Lumbar vertebral canal stenosis due to marked bone overgrowth after routine hemilaminectomy in a dog

Bone overgrowth after decompressive surgery for lumbar stenosis resulting in recurrence of neurological signs has not been reported in veterinary literature. However, there are few cases described in human medicine. A 13-month-old entire female dog, a crossbreed between a Springer Spaniel and a Border Collie, weighing 24 kg, was referred with a 5-day history of progressive spastic paraplegia, indicative of a T3-L3 myelopathy. Magnetic resonance (MR) imaging revealed a right-sided L2-L3 compressive extradural lesion, compatible with epidural haemorrhage, which was confirmed by histopathology. The lesion was approached via right-sided L2-L3 hemilaminectomy and was successfully removed. One-year postoperatively the dog re-presented with pelvic limb ataxia. MR and computed tomography (CT) images demonstrated excessive vertebral bone formation affecting the right articular processes, ventral aspect of the spinous process of L2-L3, and contiguous vertebral laminae, causing spinal cord compression. Revision surgery was performed, and histopathology revealed normal or reactive osseous tissue with a possible chondroid metaplasia and endochondral ossification, failing to identify a definitive reason for the bone overgrowth. Nine-month postoperatively, imaging studies showed a similar vertebral overgrowth, resulting in minimal spinal cord compression. The patient remained stable with mild proprioceptive ataxia up until the last follow-up 18 months post-revision surgery. This is the first report in the veterinary literature of bone overgrowth after lumbar hemilaminectomy which resulted in neurological deficits and required a revision decompressive surgery

Estrategias humanas, estabilidad y cambio en la frontere agrícola sur americana

El trabajo explora cuán estables fueron las estrategias humanas una vez que las poblaciones indígenas del centro-occidente argentino incorporaron cultígenos. Asimismo, evalúa si una vez incorporado el consumo de plantas domésticas, las estrategias fueron, o no, progresivamente apoyándose más sobre la producción y consumo de las mismas. El estudio compara tres sitios con restos humanos (Jaime Prats-1, Rincón del Atuel-1 y Cañada Seca-1) localizados entre sí a una distancia máxima de 40 km y en un valle considerado como el límite sur de la agricultura andina prehispánica. Estos sitios, que presentan una continuidad temporal, abarcan desde ca. 1900 (300 años posterior al registro inicial de las plantas domésticas en la región) a ca. 1400 años aP. Se comparan datos de isótopos estables (13C, 15N, 18O), morfometría craneal, mandibular y dental, junto a información contextual arqueológica. El sitio más antiguo, Jaime Prats-1, muestra semejanzas isotópicas y morfológicas con Cañada Seca-1, el más reciente, a pesar de no ser continuos en el tiempo. Ambos se diferencian de Rincón del Atuel-1, que temporalmente se intercala entre los dos. Los resultados señalan una mayor importancia del maíz en Rincón del Atuel-1, junto a una menor movilidad residencial, aunque en ninguno de los casos este recurso habría contribuido más del 30% a la dieta. Los sistemas humanos que ocuparon la frontera agrícola en estos primeros 500 años de uso de plantas domésticasmuestran una alta variabilidad en su organización, sin cruzar umbrales que impidan retornar a sistemas de baja producción.Fil: Gil, Adolfo Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Menendez, Lumila Paula. University of Tübingen; AlemaniaFil: Atencio, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Peralta, Eva Ailén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Neme, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Ugan, Andrew. Far Western Anthropological Research Group; Estados Unidos. Museo de Historia Natural de San Rafael; Argentin

Human ESCs predisposition to karyotypic instability: Is a matter of culture adaptation or differential vulnerability among hESC lines due to inherent properties?

<p>Abstract</p> <p>Background</p> <p>The use of human embryonic stem cells (hESCs) in research is increasing and hESCs hold the promise for many biological, clinical and toxicological studies. Human ESCs are expected to be chromosomally stable since karyotypic changes represent a pitfall for potential future applications. Recently, several studies have analysed the genomic stability of several hESC lines maintained after prolonged <it>in vitro </it>culture but controversial data has been reported. Here, we prompted to compare the chromosomal stability of three hESC lines maintained in the same laboratory using identical culture conditions and passaging methods.</p> <p>Results</p> <p>Molecular cytogenetic analyses performed in three different hESC lines maintained in parallel in identical culture conditions revealed significant differences among them in regard to their chromosomal integrity. In feeders, the HS181, SHEF-1 and SHEF-3 hESC lines were chromosomally stable up to 185 passages using either mechanical or enzymatic dissection methods. Despite the three hESC lines were maintained under identical conditions, each hESC line behaved differently upon being transferred to a feeder-free culture system. The two younger hESC lines, HS181 (71 passages) and SHEF-3 (51 passages) became chromosomally unstable shortly after being cultured in feeder-free conditions. The HS181 line gained a chromosome 12 by passage 17 and a marker by passage 21, characterized as a gain of chromosome 20 by SKY. Importantly, the mosaicism for trisomy 12 gradually increased up to 89% by passage 30, suggesting that this karyotypic abnormality provides a selective advantage. Similarly, the SHEF-3 line also acquired a trisomy of chromosome 14 as early as passage 10. However, this karyotypic aberration did not confer selective advantage to the genetically abnormal cells within the bulk culture and the level of mosaicism for the trisomy 14 remained overtime between 15%–36%. Strikingly, however, a much older hESC line, SHEF-1, which was maintained for 185 passages in feeders did not undergo any numerical or structural chromosomal change after 30 passages in feeder-free culture and over 215 passages in total.</p> <p>Conclusion</p> <p>These results support the concept that feeder-free conditions may partially contribute to hESC chromosomal changes but also confirm the hypothesis that regardless of the culture conditions, culture duration or splitting methods, some hESC lines are inherently more prone than others to karyotypic instability.</p

Clinicopathological characteristics of infiltrating lobular breast carcinoma in elderly women: Preliminary results

This study was conducted to investigate the clinicopathological parameters in elderly women (aged >70 years) with infiltrating lobular carcinoma (ILC) of the breast and compare the results with those obtained from younger patients (aged 55-70 years). The study sample included a total of 46 women with ILCs, 10 aged >70 and 36 aged 55-70 years. The parameters analysed were tumor size, histological grade (HG), axillary lymph node involvement, distant metastasis and immunohistochemical expression of estrogen, progesterone and androgen receptors, Ki67, p53 and B cell lymphoma 2. Compared to women aged 55-70 years, ILCs in women aged >70 years were commonly of larger size (P=0.068) and were more frequently HG3 (P=0.024). There were no statistically significant differences in the other parameters analysed. Furthermore, we were unable to determine differences in cancer recurrence and mortality in the two patient subgroups during our follow-up. In conclusion, our preliminary results, based on the limited number of cases included in this study, indicate that i) ILCs in women aged >70 years tended to be larger compared to those in women aged 55-70 years and were more frequently of grade 3; and ii) there were no significant differences in terms of recurrence and mortality between the two patient subgroups during our follow-up

Uso de situaciones problematicas abiertas en las clases prácticas de fisica: una innovación

Los fracasos en el examen final y el alto porcentaje de repitentes de la asignatura Física del primer año de las carreras de Ingeniería, requieren una revisión del desarrollo de las clases. En la actualidad la asignatura se instrumenta esencialmente en: clases teóricas, para abordar los conceptos básicos, clases prácticas en las que se resuelven ejercicios y clases de laboratorio en donde se verifican principios y/o leyes desarrolladas en las clases teóricas. Tanto en las clases prácticas como en las de laboratorio, los estudiantes cuentan con guías que contienen ejercicios y problemas cerrados. Con el objeto aportar una solución para palear el problema planteado, en este trabajo se describe el desarrollo de un proyecto de innovación en las clases prácticas basado en la inclusión de situaciones problemáticas abiertas y las apreciaciones realizadas por los estudiantes de la nueva propuesta.Facultad de Humanidades y Ciencias de la Educació

A ACEITAÇÃO DE UM NOVO SISTEMA EM UMA INSTITUIÇÃO FEDERAL DE ENSINO PELA PERSPECTIVA DO MODELO UTAUT

Novos sistemas de informações podem ser vistos como tecnologias que provocam mudança no ambiente do usuário e essas mudanças muitas vezes não são bem-vindas. Para as instituições de ensino federal, existe um novo sistema que está em implantação chamado Sistema Integrado de Gestão de Atividades Acadêmicas (SIGAA). A aceitação dos usuários do novo sistema é fundamental para o progresso das instituições. O objetivo desse artigo é analisar o SIGAA pela perspectiva dos professores da Fundação Universidade Federal de Rondônia (UNIR) utilizando o modelo UTAUT como base teórica. Esse estudo é descritivo e foi realizado utilizando de um estudo de campo com aplicação de questionário e pesquisa documental. Conclui-se que o novo sistema é visto como mais eficaz e melhor que o antigo, mas alerta-se na questão de melhorar ou facilitar a utilização do sistema