147 research outputs found
Behavioral sensitization to cocaine: cooperation between glucocorticoids and epinephrine
- Author
- A Badiani
- A Badiani
- A Der-Avakian
- A Harfstrand
- AD Le
- B Roozendaal
- B Roozendaal
- B Roozendaal
- BA Sorg
- BM Prasad
- C Drouin
- C Drouin
- CC Chiueh
- CL Williams
- CN Haile
- DB Sternberg
- E Przegalinski
- E. Ronald de Kloet
- ED Schmidt
- ED Schmidt
- ER Kloet De
- G Blanc
- GD Gamaro
- GJ Marek
- GL Quirarte
- H Weil-Malherbe
- IEM Jong De
- IEM Jong De
- IEM Jong De
- Inge E. M. de Jong
- J Borrell
- J Borrell
- JA Ihalainen
- JD Steketee
- JM Reul
- JM Rivet
- JP Herman
- JR Mantsch
- JR Pauly
- JW Tidey
- K Fuxe
- KC Liang
- KC Liang
- L Darracq
- L Salomon
- LB Lepsch
- LJ Vanderschuren
- LJ Vanderschuren
- LJ Vanderschuren
- M Buuse Van den
- M Haney
- M Marinelli
- NE Goeders
- NE Goeders
- NE Goeders
- P Kovacs
- PE Gold
- PE Gold
- PE Gold
- Peter J. Steenbergen
- PV Piazza
- PV Piazza
- PV Piazza
- R Izawa
- R Loy
- R Ventura
- RC Pierce
- S Cabib
- S Erb
- SB Floresco
- SM Florin
- T Lewander
- T Miyashita
- TG Robinson
- V Deroche
- V Deroche-Gamonet
- WH Pan
- WH Pan
- Y Shaham
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2009
- Field of study
Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells
- Author
- A Marinelli
- A Mori
- A Supersaxo
- AL Vahrmeijer
- C Thomas
- CE Myers
- CJF Böttcher
- D Hoekstra
- D Liu
- D Papahadjopoulos
- FJ Martin
- G Gregoriadis
- G Storm
- GD Beun
- GD Beun
- GL Petterson
- GL Scherphof
- GL Scherphof
- GL Scherphof
- I Ahmad
- J Vaage
- JAAM Kamps
- JTP Derksen
- JTP Derksen
- K Maruyama
- KP Dingemans
- LD Mayer
- M Van Borssum Waalkes
- M Van Borssum Waalkes
- M Van Borssum Waalkes
- N Kemeny
- NE Kemeny
- NJ Meropol
- OH Lowry
- PV Danenberg
- RA Schwendener
- RL Marquet
- SC Kinsky
- TM Allen
- TM Allen
- TM Allen
- WD Ensminger
- Y Nishizawa
- Publication venue
- Nature Publishing Group
- Publication date
- 01/08/1999
- Field of study
We have investigated the antiproliferative action towards CC531 colon adenocarcinoma cells of target cell-specific immunoliposomes containing the amphiphilic dipalmitoyl derivative of 5-fluorodeoxyuridine (FUdR-dP). FUdR-dP incorporated in immunoliposomes caused a 13-fold stronger inhibition of CC531 cell growth in vitro, during a 72-h treatment, than FUdR-dP in liposomes without antibody, demonstrating that the prodrug is efficiently hydrolysed to yield the active drug, FUdR, intracellularly. The intracellular release of active FUdR was confirmed by determining the fate of H-3-labelled immunoliposomal FUdR-dP. Treatments shorter than 72 h with FUdR-dP in immunoliposomes resulted in anti-tumour activities comparable to, or even higher than, that of free FUdR. The shorter treatments reflect more closely the in vivo situation and illustrate the potential advantage of the use of immunoliposomes over non-targeted liposomal FUdR-dP or free FUdR. Association of tumour cell-specific immunoliposomes with CC531 cells was up to tenfold higher than that of liposomes without antibody or with irrelevant IgG coupled, demonstrating a specific interaction between liposomes and target cells which causes an efficient intracellular delivery of the drug. Since biochemical evidence indicates a lack of internalization or degradation of the liposomes as such; we postulate that entry of the drug most likely involves the direct transfer of the prodrug from the immunoliposome to the cell membrane during its antigen-specific interaction with the cells. followed by hydrolysis of FUdR-dP leading to relatively high intracellular FUdR-levels. In conclusion, we describe a targeted liposomal formulation for the anticancer drug FUdR, which is able to deliver the active drug to colon carcinoma cells with high efficiency, without the need for the cells to internalize the liposomes as such
Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress
- Author
- A Cippitelli
- A Cippitelli
- A Cippitelli
- A Ettenberg
- A Ettenberg
- A Plaza-Zabala
- A Sekino
- A Van't Veer
- AC Hansson
- AD Le
- AD Le
- AD Le
- AD Le
- AD Le
- AD Le
- AD Le
- AD Le
- AD Le
- AE Higley
- AM Chirila
- AM Polter
- AM Thierry
- AN Carey
- Anh D LĂȘ
- AS Kreibich
- AY Deutch
- B Boutrel
- B Lee
- B Ribeiro Do Couto
- B Setlow
- B Wang
- B Wang
- B Wang
- B Wang
- B Wang
- BB Land
- BH Westerink
- BL Lewis
- BM Cox
- BR Lee
- C Cifani
- C Li
- CD Schmoutz
- CJ Sanchez
- CJ Sanchez
- CK Nielsen
- CL Pickens
- CP Ford
- CP O'Brien
- CR Gerfen
- D Economidou
- D Epstein
- D Funk
- D Funk
- D Highfield
- D Highfield
- D Highfield
- D Liu
- D Rodaros
- D Rotllant
- David A Baker
- DC Glass
- DEJ Redmond
- DH Epstein
- DJ Calu
- DJ Calu
- DM Buffalari
- DM Buffalari
- DM Buffalari
- Douglas Funk
- DR Gehlert
- DR Staub
- DS Zahm
- DT George
- DW Schulz
- DW Self
- E Krupitsky
- EA Stone
- EB Margolis
- EJ Khantzian
- EN Graf
- EN Graf
- EP Zorrilla
- EP Zorrilla
- F Chaouloff
- F Cohen
- F Georges
- F Leri
- F Sedki
- F Weiss
- FC Cruz
- FJ White
- G Aston-Jones
- G de Guglielmo
- G Zislis
- GF Koob
- GP Chrousos
- GR Valdez
- H Selye
- H Yamada
- HC Fox
- HC Fox
- J Jenkins
- J Stewart
- J Wang
- JA Deutch
- JA Gray
- JA Simms
- JC Umhau
- JD Bremner
- JD Bremner
- JD Shepard
- JE LeDoux
- JE Morley
- JJ Anker
- JJ Anker
- JK Richards
- JK Seamans
- JL McGaugh
- JM Blacktop
- JM Bossert
- JM Bossert
- JM Bossert
- JM Fritschy
- JN Cleck
- John R Mantsch
- JP McLaughlin
- JP Schroeder
- JR Glowa
- JR Mantsch
- JR Mantsch
- JR Mantsch
- JR Mantsch
- JR McReynolds
- JR Schank
- JR Schank
- JR Schank
- JV Aldrich
- JV Aldrich
- K McFarland
- K Van Pett
- KJ Jackson
- KL Conrad
- KL Shelton
- L Lu
- L Lu
- L Lu
- L Lu
- L Zhou
- LA Briand
- LE Kwako
- LG Kirby
- LK Vaughn
- M Davis
- M Davis
- M Heilig
- M Sakanaka
- MA Ungless
- MB Bannon
- MD Cassell
- ME Bouton
- ME Bouton
- ME Carroll
- MEP Seligman
- MF Dallman
- MK Greenwald
- ML Jobes
- ML Price
- MM Moran-Santa Maria
- MM Moran-Santa Maria
- MR Bruchas
- MR Bruchas
- MT Stefanik
- MW Feltenstein
- MW Feltenstein
- MW Hale
- N Capriles
- N Omelchenko
- N Sidhpura
- NA Chen
- NM Graziane
- O Vranjkovic
- O Vranjkovic
- P Enrico
- PE Sawchenko
- PJ Fletcher
- PM Beardsley
- PM Beardsley
- PS Regier
- PV Piazza
- PW Kalivas
- PW Kalivas
- PW Kalivas
- PW Marinelli
- R Ciccocioppo
- R Haynes
- R Kvetnansky
- R Martin-Fardon
- R Mongeau
- R Sinha
- R Sinha
- R Sinha
- R Sinha
- R Sinha
- R Sinha
- R Sinha
- R Sinha
- R Takahata
- RC Pierce
- RC Twining
- RD Weiss
- RE See
- RE See
- RJ Smith
- RM Gold
- RP Vertes
- RP Vertes
- RP Waters
- RY Moore
- S Cabib
- S Cohen
- S Erb
- S Erb
- S Erb
- S Erb
- S Erb
- S Erb
- S Erb
- S Fanous
- S Geisler
- S Grimwood
- S Shiffman
- S Stopponi
- S Stopponi
- S Stopponi
- S Tobin
- S Tobin
- SA Flavin
- SE Back
- SF Maier
- SF Maier
- SG Nair
- SG Nair
- SG Nair
- SH Ahmed
- SH Ahmed
- SL Grella
- SM Antelman
- SO Eans
- SR Bornstein
- SR Sesack
- SV Mahler
- SV Mahler
- T Holdstock
- T Maric
- TL Bale
- TR Kosten
- U Shalev
- U Shalev
- U Shalev
- U Shalev
- U Shalev
- U Shalev
- UE Ghitza
- V Deroche
- VA Redila
- WA Hunt
- WB Cannon
- WM Meil
- X Liu
- X Liu
- X Wang
- Y Buczek
- Y Figueroa-Guzman
- Y Nawata
- Y Shaham
- Y Shaham
- Y Shaham
- Y Shaham
- Y Shaham
- Y Shaham
- Y Shaham
- Y Silberman
- Y Zhao
- Yavin Shaham
- YW Chen
- YY Ma
- YY Ma
- Z Sarnyai
- ZJ Brown
- ZJ Brown
- ZX Xi
- Publication venue
- e-Publications@Marquette
- Publication date
- 24/06/2015
- Field of study
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking. Here, we first discuss the generality of stress-induced reinstatement to different drugs of abuse, different stressors, and different behavioral procedures. We also discuss neuropharmacological mechanisms, and brain areas and circuits controlling stress-induced reinstatement of drug seeking. We conclude by discussing results from translational human laboratory studies and clinical trials that were inspired by results from rat studies on stress-induced reinstatement. Our main conclusions are (1) The phenomenon of stress-induced reinstatement, first shown with an intermittent footshock stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicotine, and alcohol, and is also observed in the conditioned place preference model in rats and mice. This phenomenon, however, is stressor specific and not all stressors induce reinstatement of drug seeking. (2) Neuropharmacological studies indicate the involvement of corticotropin-releasing factor (CRF), noradrenaline, dopamine, glutamate, kappa/dynorphin, and several other peptide and neurotransmitter systems in stress-induced reinstatement. Neuropharmacology and circuitry studies indicate the involvement of CRF and noradrenaline transmission in bed nucleus of stria terminalis and central amygdala, and dopamine, CRF, kappa/dynorphin, and glutamate transmission in other components of the mesocorticolimbic dopamine system (ventral tegmental area, medial prefrontal cortex, orbitofrontal cortex, and nucleus accumbens). (3) Translational human laboratory studies and a recent clinical trial study show the efficacy of alpha-2 adrenoceptor agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse
Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cellsâ activity
- Author
- A Armario
- A Bailey
- A Metaxas
- A Ostroumov
- A Saricicek
- AK Friedman
- AK Goodwin
- AW Bruijnzeel
- C Czermak
- C Gotti
- C Morel
- C Morel
- D Chaudhury
- D Saal
- EG Mohler
- EJ Nestler
- ES Bromberg-Martin
- F Brischoux
- F J Meye
- F Marti
- F Marti
- F Pantouli
- F Tronche
- G Di Chiara
- GC Patton
- GF Koob
- H Marie
- HD Mansvelder
- IW Jones
- J Barik
- J Barik
- J-L Cao
- JA Dani
- JH Mendelson
- JL Niehaus
- M Besson
- M Gao
- M Mameli
- M Marinelli
- M Moretti
- M Siahpush
- M Zoli
- M-H Han
- MA Ungless
- MA Ungless
- MR Picciotto
- N Breslau
- ND Volkow
- NL Benowitz
- O KlungsĂžyr
- P Faure
- P Faure
- PD Livingstone
- PV Piazza
- RS Hurst
- S Cohen
- S Lammel
- S P Fernandez
- S Parnaudeau
- S Tolu
- S Tolu
- SC Leiser
- SD Grabus
- SS Daftary
- U Maskos
- V Krishnan
- WM Doyon
- YS Mineur
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/07/2017
- Field of study
Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in mood disorders. Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (DA) system. This interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (VTA) DA neuronsâ
activity and stress-related behaviors, such as social aversion. Blocking ÎČ2 or α7 nicotinic acetylcholine receptors (nAChRs) prevents, respectively, the development and the expression of social stress-induced neuroadaptations; conversely, facilitating α7 nAChRs activation specifically in the VTA promotes stress-induced
cellular and behavioral maladaptations. Our work unravels a complex nicotine-stress bidirectional interplay and identifies α7 nAChRs as a promising therapeutic target for stress-related psychiatric disorders
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
- Burgess JM
- Burgman A
- Burhonov O
- Burke DL
- Burns E
- Burrows DN
- Buscemi M
- Buskulic D
- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
- Butler RE
- Buttu M
- Buy C
- Byer RL
- Caballero-Garcia MD
- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
- Cardillo M
- Caria T
- Caride S
- Carlin JL
- Carney MF
- Caroff S
- Carosi A
- Carr J
- Carramiana A
- Carretti E
- Cartier R
- Caruso R
- Carver T
- Casadio C
- Casado A Lopez
- Casanova S
- Casanova S
- Casasola V
- Casella P
- Casentini C
- Casey J
- Casier M
- Castander FJ
- Castangia P
- Castellina A
- Castellon A
- Castellon JL Nilo
- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
- Castro-Tirado AJ
- Casu S
- Catalani F
- Cataldi G
- Cattaneo PW
- Caudill S
- Cavagli M
- Cavalier F
- Cavalieri R
- Cavazzuti E
- Cazon L
- Cella G
- Celli S
- Cenko SB
- Cepeda CB
- Cerd-Durn P
- Ceron JM Castro
- Cerretani G
- Cerruti M
- Cerutti AC Cobos
- Cesarini E
- Chakraborty N
- Chamberlin SJ
- Chambers KC
- Chan M
- Chandra P
- Chang S-W
- Chang Z
- Chao S
- Charlton P
- Chase E
- Chassande-Mottin E
- Chatterjee D
- Chatterjee D
- Chatziioannou K
- Chaves RCG
- Chavez AG
- Chavushyan V
- Cheeseboro BD
- Chekhtman A
- Chen A
- Chen G
- Chen HY
- Chen L
- Chen T-W
- Chen TX
- Chen X
- Chen Y
- Chen Y
- Chen YB
- Chen YP
- Chenevez J
- Cheng H-P
- Cherry ML
- Cheung CC
- Cheung E
- Chevalier J
- Chia H
- Chiang J
- Chiarusi T
- Chincarini A
- Chinellato JA
- Chirkin D
- Chiummo A
- Chmiel T
- Cho HS
- Cho M
- Choi C
- Choi J-S
- Chornock R
- Chow JH
- Christensen N
- Christov A
- Chu Q
- Chua AJK
- Chua S
- Chudoba J
- Chung AKW
- Chung S
- Ciani G
- Cikota A
- Ciolfi R
- Ciprini S
- Circella M
- Cirelli CE
- Cirone A
- Clara F
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- Li XB
- Li XF
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- Rojas-Bravo C
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- Sadler EM
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- Salvadori I
- Salvaterra R
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- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
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- Sanchez LE
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- Sand DJ
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- Sato R
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- Schneider A
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- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
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- Schulz A
- Schulz A
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- Schwalbe SG
- Schwanke U
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- Sciutto SJ
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- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
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- Sergeev A
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- Sevilla-Noarbe I
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- Shimomukai R
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- Shoemaker DH
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- Siemens X
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- Starling RLC
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transientâs position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
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- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
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- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution
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- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2020
- Field of study
We describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in proton-proton collisions at an energy of s = 13 TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb - 1 . A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ÂŻ
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
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- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
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- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
ICAR: endoscopic skullâbase surgery
- Author
- Aaron G
- Aaron GP
- Abergel A
- Abouaf L
- Abrishamkar S
- Acioly MA
- Acioly MA
- Acuna RT
- Adams AS
- Adappa ND
- Aferzon M
- Agaimy A
- Agarwal A
- Aggarwal A
- Agrawal D
- Ahmed OH
- Aihara M
- Akagami R
- Alahmadi H
- Albu S
- Albu S
- Albu S
- Alexander A
- Alimohamadi M
- Almefty R
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almond MC
- Alobaid A
- Alobid I
- Alobid I
- Alos L
- AlQahtani A
- Altay T
- Alvarez FL
- Alves MV
- AlâMamgani A
- AlâMefty O
- AlâSheibani S
- Amano K
- Amdur RJ
- Amelot A
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
- Amichetti M
- Amin SM
- Amit M
- Amit M
- Amit M
- Ammirati M
- Anari S
- Anderson D
- Anderson RL
- Andrade NA
- Andrews JC
- Anik I
- Ansa B
- Ansari M
- Antonelli AR
- Arafah BM
- Arafah BM
- Arafah BM.
- Arai A
- Arat YO
- Arbolay OL
- Ardehali MM
- Armengot M
- Arnautovic KI
- Arrer E
- Arslan HH
- Aryan HE
- Asano S
- Askoxylakis V
- Astrup J
- Awad AJ
- Awad M
- Azad TD
- Aziz KM
- Babin E
- Bachmann G
- Back L
- Backlund EO.
- Baijal V
- Balaker AE
- Ballah D
- Balzer JR
- Banks CA
- Banu MA
- Banu MA
- Banuchi VE
- Barnes L
- Baser B
- Baskin DS
- Battaglia P
- Battaglia P
- Becker AM
- Beckhardt RN
- Bedi AD
- Bedrosian JC
- Bedrosian JC
- BeerâFurlan A
- BeerâFurlan A
- Beham A
- Bejjani GK
- Bell D
- Bell RB
- Bell RB
- Berdahl JP
- Berhouma M
- Berker M
- Berker M
- Berkmann S
- Berkmann S
- Berkmann S
- BernalâSprekelsen M
- BernalâSprekelsen M
- Bernat AL
- Bertrand B
- Bhasker S
- Bhatti SN
- Bidot S
- Bills DC
- Bishop JA
- Biswas D
- Black PM
- Bleier BS
- Bleier BS
- Bleier BS
- Bleier BS
- Bleier BS
- Bloch C
- Bloch O
- Bly RA
- Boghani Z
- Bohman LE
- Bohman LE
- Bokhari AR
- Boling CC
- Bolzoni Villaret A
- Borg A
- Borghei P
- Boukheris H
- Brackmann DE
- Bradley PJ
- Branston NM
- Brastianos PK
- Bremer JW
- Bresson D
- Briet C
- Briggs RJ
- Brodie HA.
- Brown SM
- Bruchhage KL
- BruckerâDavis F
- Brunworth J
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- Zrebeet HA
- Zuccaro G.
- Zuniga MG
- Zwagerman NT
- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
The development of sensitization to the psychomotor stimulant effects of amphetamine is enhanced in a novel environment
- Author
- A Badiani
- A Morimoto
- A. Badiani
- AM Thierry
- AR Cools
- BA Mattingly
- BJ Cole
- BJ Sahakian
- CHM Beck
- DC Hoffman
- DS Segal
- EA Kiyatkin
- ED Abercrombie
- EHJ Ellinwood
- EHJ Ellinwood
- EJ Mazurski
- EMC Terlouw
- F Hefti
- F Hefti
- GR Breese
- H Anisman
- H Einat
- HA Tilson
- J Stewart
- J Stewart
- J Stewart
- J Stewart
- JL Williams
- JM Rivet
- JR Pauly
- JW Hennessy
- M Cador
- M Cador
- M Hirabayashi
- M Marinelli
- MB Hennessy
- MB Hennessy
- MT Bardo
- P Vezina
- P Willner
- PV Piazza
- PW Kalivas
- R Sullivan
- RA Wilcox
- RE Hinson
- RL Russel
- RM Post
- S Anagnostaras
- S. G. Anagnostaras
- SB Friedman
- SM Antelman
- SR Schiff
- SR Weiss
- T Schallert
- T. E. Robinson
- TE Robinson
- TE Robinson
- TE Robinson
- TE Robinson
- TE Robinson
- U Ungerstedt
- V Deroche
- V Deroche
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1995
- Field of study
Two experiments were designed to assess the effect of a ânovelâ environment on the development of sensitization to the psychomotor activating effects of d -amphetamine. In the first experiment, rats with a unilateral 6-hydroxydopamine lesion of the mesostriatal dopamine system received ten daily injections of amphetamine (2 mg/kg), either in their home cages or in novel test cages. The home and novel cages were physically identical (cylindrical transparent buckets), but one group lived and were tested in these cages, whereas the other group was transported from the stainless steel hanging cages where they lived to these novel test cages, for each test session. The first injection of amphetamine produced significantly more rotational behavior in animals tested in a novel environment than in animals tested at home. In addition, animals tested in a novel environment showed greater sensitization than animals tested at home, so the difference between the two groups was even more pronounced following the last injection. In a second experiment, locomotor activity was quantified in rats that received ten injections of either saline or 1.5 mg/kg amphetamine, in their home cages or in a physically identical novel environment. Again, there was a significantly greater locomotor response to the first injection of amphetamine, and greater sensitization, in animals tested in a novel environment than in animals tested at home. These data indicate that environmental factors can exert a large effect on the susceptibility to sensitization, and mechanisms by which this may occur are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46345/1/213_2005_Article_BF02246217.pd
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