Testing Lorentz symmetry with Lunar Laser Ranging

Lorentz symmetry violations can be parametrized by an effective field theory framework that contains both general relativity and the standard model of particle physics called the standard-model extension (SME). We present new constraints on pure gravity SME coefficients obtained by analyzing lunar laser ranging (LLR) observations. We use a new numerical lunar ephemeris computed in the SME framework and we perform a LLR data analysis using a set of 20721 normal points covering the period of August, 1969 to December, 2013. We emphasize that linear combination of SME coefficients to which LLR data are sensitive and not the same as those fitted in previous postfit residuals analysis using LLR observations and based on theoretical grounds. We found no evidence for Lorentz violation at the level of $10^{-8}$ for $\bar{s}^{TX}$, $10^{-12}$ for $\bar{s}^{XY}$ and $\bar{s}^{XZ}$, $10^{-11}$ for $\bar{s}^{XX}-\bar{s}^{YY}$ and $\bar{s}^{XX}+\bar{s}^{YY}-2\bar{s}^{ZZ}-4.5\bar{s}^{YZ}$ and $10^{-9}$ for $\bar{s}^{TY}+0.43\bar{s}^{TZ}$. We improve previous constraints on SME coefficient by a factor up to 5 and 800 compared to postfit residuals analysis of respectively binary pulsars and LLR observations

Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines

Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W, and Y. More recently two protein-based vaccines, Bexsero and Trumenba, against meningococcal serogroup B strains have been licensed; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface-exposed lipoprotein that binds the negative complement regulator complement factor H (CFH), thereby inhibiting the alternative pathway of complement activation. Recent analysis of available genomes has indicated that some commensal Neisseria species also contain genes that potentially encode fHbp, although the functions of these genes and how immunization with fHbp-containing vaccines could affect the commensal flora have yet to be established. Here, we show that the commensal species Neisseria cinerea expresses functional fHbp on its surface and that it is responsible for recruitment of CFH by the bacterium. N. cinerea fHbp binds CFH with affinity similar to that of meningococcal fHbp and promotes survival of N. cinerea in human serum. We examined the potential impact of fHbp-containing vaccines on N. cinerea. We found that immunization with Bexsero elicits serum bactericidal activity a gainst N. cinerea, which is primarily directed against fHbp. The shared function of fHbp in N. cinerea and N. meningitidis and cross-reactive responses elicited by Bexsero suggest that the introduction of fHbp-containing vaccines has the potential to affect carriage of N. cinerea and other commensal species

Testing Gravitation in the Solar System with Radio Science experiments

The laws of gravitation have been tested for a long time with steadily improving precision, leading at some moment of time to paradigmatic evolutions. Pursuing this continual effort is of great importance for science. In this communication, we focus on Solar System tests of gravity and more precisely on possible tests that can be performed with radio science observations (Range and Doppler). After briefly reviewing the current tests of gravitation at Solar System scales, we give motivations to continue such experiments. In order to obtain signature and estimate the amplitude of anomalous signals that could show up in radio science observables because of modified gravitational laws, we developed a new software that simulates Range/Doppler signals. We present this new tool that simulates radio science observables directly from the space-time metric. We apply this tool to the Cassini mission during its cruise from Jupiter to Saturn and derive constraints on the parameters entering alternative theories of gravity beyond the standard Parametrized Post Newtonian theory.Comment: proceedings of SF2A 2011 - minor changes (typos corrected - references updated

Radioscience simulations in General Relativity and in alternative theories of gravity

In this communication, we focus on the possibility to test GR with radioscience experiments. We present a new software that in a first step simulates the Range/Doppler signals directly from the space time metric (thus in GR and in alternative theories of gravity). In a second step, a least-squares fit of the involved parameters is performed in GR. This software allows one to get the order of magnitude and the signature of the modifications induced by an alternative theory of gravity on radioscience signals. As examples, we present some simulations for the Cassini mission in Post-Einsteinian gravity and with the MOND External Field Effect.Comment: 4 pages; Proceedings of "Les Rencontres de Moriond 2011 - Gravitation session

General post-Minkowskian expansion of time transfer functions

Modeling most of the tests of general relativity requires to know the function relating light travel time to the coordinate time of reception and to the spatial coordinates of the emitter and the receiver. We call such a function the reception time transfer function. Of course, an emission time transfer function may as well be considered. We present here a recursive procedure enabling to expand each time transfer function into a perturbative series of ascending powers of the Newtonian gravitational constant $G$ (general post-Minkowskian expansion). Our method is self-sufficient, in the sense that neither the integration of null geodesic equations nor the determination of Synge's world function are necessary. To illustrate the method, the time transfer function of a three-parameter family of static, spherically symmetric metrics is derived within the post-linear approximation.Comment: 10 pages. Minor modifications. Accepted in Classical and Quantum Gravit

Direction of light propagation to order G^2 in static, spherically symmetric spacetimes: a new derivation

A procedure avoiding any integration of the null geodesic equations is used to derive the direction of light propagation in a three-parameter family of static, spherically symmetric spacetimes within the post-post-Minkowskian approximation. Quasi-Cartesian isotropic coordinates adapted to the symmetries of spacetime are systematically used. It is found that the expression of the angle formed by two light rays as measured by a static observer staying at a given point is remarkably simple in these coordinates. The attention is mainly focused on the null geodesic paths that we call the "quasi-Minkowskian light rays". The vector-like functions characterizing the direction of propagation of such light rays at their points of emission and reception are firstly obtained in the generic case where these points are both located at a finite distance from the centre of symmetry. The direction of propagation of the quasi-Minkowskian light rays emitted at infinity is then straightforwardly deduced. An intrinsic definition of the gravitational deflection angle relative to a static observer located at a finite distance is proposed for these rays. The expression inferred from this definition extends the formula currently used in VLBI astrometry up to the second order in the gravitational constant G.Comment: 19 pages; revised introduction; added references for introduction; corrected typos; published in Class. Quantum Gra

Accurate light-time correction due to a gravitating mass

This work arose as an aftermath of Cassini's 2002 experiment \cite{bblipt03}, in which the PPN parameter $\gamma$ was measured with an accuracy $\sigma_\gamma = 2.3\times 10^{-5}$ and found consistent with the prediction $\gamma =1$ of general relativity. The Orbit Determination Program (ODP) of NASA's Jet Propulsion Laboratory, which was used in the data analysis, is based on an expression for the gravitational delay which differs from the standard formula; this difference is of second order in powers of $m$ -- the sun's gravitational radius -- but in Cassini's case it was much larger than the expected order of magnitude $m^2/b$, where $b$ is the ray's closest approach distance. Since the ODP does not account for any other second-order terms, it is necessary, also in view of future more accurate experiments, to systematically evaluate higher order corrections and to determine which terms are significant. Light propagation in a static spacetime is equivalent to a problem in ordinary geometrical optics; Fermat's action functional at its minimum is just the light-time between the two end points A and B. A new and powerful formulation is thus obtained. Asymptotic power series are necessary to provide a safe and automatic way of selecting which terms to keep at each order. Higher order approximations to the delay and the deflection are obtained. We also show that in a close superior conjunction, when $b$ is much smaller than the distances of A and B from the Sun, of order $R$, say, the second-order correction has an \emph{enhanced} part of order $m^2R/b^2$, which corresponds just to the second-order terms introduced in the ODP. Gravitational deflection of the image of a far away source, observed from a finite distance from the mass, is obtained to $O(m^2)$.Comment: 4 figure

'Thank you for loving me': A qualitative study on perceptions of gratitude and their effects in palliative care patients and relatives.

Empirical studies suggest that gratitude positively influence the quality of life of palliative patients and relatives. However, the literature is marked by a lack of conceptual clarity about what gratitude is and whether it can bring about individual and social benefits. This paper explores how palliative care patients and relatives understand gratitude, how discursive representations of gratitude may affect their positions, perceptions and relations, and how to conceptualise gratitude in the palliative context. We examine 33 gratitude letters written by patients and relatives and 25 semi-structured interviews conducted as part of a pilot gratitude intervention study. We use a qualitative approach, thematic analysis, within a conceptual framework of discourse analysis. Data were collected from 23 patients and 13 relatives recruited through three hospital palliative care services in French-speaking Switzerland. Participants articulate gratitude in five ways: (1) appreciating others; (2) love; (3) need to reciprocate; (4) appreciating the little things; (5) solace amid serious illness. While some of these representations are sources of positive emotions and outlook, wellbeing and hope, others may confirm self-perceptions of powerlessness and burden. These results support a tridimensional conceptualisation of gratitude in palliative care as source of individual benefits, valuing closest relationships and moral obligation. Our study suggests that gratitude is a key to a good (end of) life, whilst highlighting potential negative effects. It could help healthcare professionals to better understand what gratitude means to patients and relatives, which may facilitate awareness and fostering of gratitude in palliative care

INPOP08, a 4-D planetary ephemeris: From asteroid and time-scale computations to ESA Mars Express and Venus Express contributions

The latest version of the planetary ephemerides developed at the Paris Observatory and at the Besancon Observatory is presented here. INPOP08 is a 4-dimension ephemeris since it provides to users positions and velocities of planets and the relation between TT and TDB. Investigations leading to improve the modeling of asteroids are described as well as the new sets of observations used for the fit of INPOP08. New observations provided by the European Space Agency (ESA) deduced from the tracking of the Mars Express (MEX) and Venus Express (VEX) missions are presented as well as the normal point deduced from the Cassini mission. We show the huge impact brought by these observations in the fit of INPOP08, especially in terms of Venus, Saturn and Earth-Moon barycenter orbits.Comment: 14 pages. submitted to A&A. accepted in A&