Finite Element Analysis of Adhesively Bonded Lap Joints

Adhesive bonding is a preferred method of joining aerospace structural components, since it provides fewer points of stress concentration compared to fastener joints. Geometrically nonlinear analysis of adhesively bonded lap joints is presented in this paper using both linear and non-linear material properties of the adhesive. The numerical results show beneficial effects of material non-linear behaviour of the adhesive which decrease the stress concentration at the ends of the lap Length. This paper also presents the estimation of strain-energy-release rate components in the presence of debond in the adhesive. The studies have relevance in structural integrity assessment of the joints

Hand gesture recognition system based in computer vision and machine learning

"Lecture notes in computational vision and biomechanics series, ISSN 2212-9391, vol. 19"Hand gesture recognition is a natural way of human computer interaction and an area of very active research in computer vision and machine learning. This is an area with many different possible applications, giving users a simpler and more natural way to communicate with robots/systems interfaces, without the need for extra devices. So, the primary goal of gesture recognition research applied to Human-Computer Interaction (HCI) is to create systems, which can identify specific human gestures and use them to convey information or controlling devices. For that, vision-based hand gesture interfaces require fast and extremely robust hand detection, and gesture recognition in real time. This paper presents a solution, generic enough, with the help of machine learning algorithms, allowing its application in a wide range of human-computer interfaces, for real-time gesture recognition. Experiments carried out showed that the system was able to achieve an accuracy of 99.4% in terms of hand posture recognition and an average accuracy of 93.72% in terms of dynamic gesture recognition. To validate the proposed framework, two applications were implemented. The first one is a real-time system able to help a robotic soccer referee judge a game in real time. The prototype combines a vision-based hand gesture recognition system with a formal language definition, the Referee CommLang, into what is called the Referee Command Language Interface System (ReCLIS). The second one is a real-time system able to interpret the Portuguese Sign Language. Sign languages are not standard and universal and the grammars differ from country to country. Although the implemented prototype was only trained to recognize the vowels, it is easily extended to recognize the rest of the alphabet, being a solid foundation for the development of any vision-based sign language recognition user interface system.(undefined

Preparación y caracterización físicoquímica de una microemulsión de macrogol -8- glicéridos de caprilocaproilo para la administración oral de fármacos

The performance of caprylocapryl macrogol -8- glycerides in the development of pharmaceutically acceptable, stable, selfemulsifyingmicroemulsion was assessed. The suitability of the concentration of surfactant with respect to the oil phasewas assessed by interfacial tension measurement. A pseudoternary microemulsion system was constructed using caprylocaprylmacrogol -8- glycerides / polyglyceryl 6-dioleate / medium chain triglycerides and water. The model microemulsion wascharacterised with regard to its electroconductive behaviour and droplet size measurement after dilution with water aswell as with simulated gastric fluid, surface charge, centrifugal stability, viscosity and stability studies. The percolationtransition theory, which makes it possible to determine the percolation threshold and to identify the bicontinuousstructures, was applied to the system. The interfacial tension changes associated with the microemulsion formation showsultra low values upto 30% oil at a surfactant / cosurfactant ratio 4:1. Moreover, the investigated particle size after dilutionwith excess of water as well as with simulated gastric fluid proved the efficiency of the microemulsion system as a potentialcarrier for oral drug delivery.Se evaluó el rendimiento de los macrogol -8- glicéridos de caprilocaproilo en el desarrollo de una microemulsiónautoemulsionante, estable y aceptable desde el punto de vista farmacológico. Se evaluó la idoneidad de la concentraciónde surfactante en relación con la fase oleosa a través de la medición de la tensión interfacial. Se elaboró unsistema de microemulsiones pseudoternario con macrogol -8- glicéridos de caprilocaproilo/poligliceril 6-dioleato/triglicéridos de cadena media y agua. La microemulsión modelo se caracterizó en relación con su comportamientoelectroconductivo y la medición del tamaño de las gotitas tras su dilución en agua y fluido gástrico simulado, y serealizaron estudios de carga de superficie, estabilidad centrífuga, viscosidad y estabilidad. Se aplicó la teoría de latransición de percolación al sistema, lo que hizo posible la determinación del umbral de percolación y la identificaciónde las estructuras bicontinuas. Los cambios de tensión interfacial asociados a la formación de las microemulsionesmostraron valores muy bajos, hasta un 30% de aceite en una proporción 4:1 de surfactante/cosurfactante. Además,el tamaño de las partículas investigadas tras la dilución en agua abundante y en fluido gástrico simulado demostraronla eficacia del sistema de microemulsiones como un posible sistema de transporte para la administración oral defármacos

Discussion on a possible neutrino detector located in India

We have identified some important and worthwhile physics opportunitites with a possible neutrino detector located in India. Particular emphasis is placed on the geographical advantage with a stress on the complimentary aspects with respect to other neutrino detectors already in operation.Comment: 9 pages; arXiv copy of published proceedings contributio

Rapid Assessment of Avoidable Blindness in India

BACKGROUND: Rapid assessment of avoidable blindness provides valid estimates in a short period of time to assess the magnitude and causes of avoidable blindness. The study determined magnitude and causes of avoidable blindness in India in 2007 among the 50+ population. METHODS AND FINDINGS: Sixteen randomly selected districts where blindness surveys were undertaken 7 to 10 years earlier were identified for a follow up survey. Stratified cluster sampling was used and 25 clusters (20 rural and 5 urban) were randomly picked in each district.. After a random start, 100 individuals aged 50+ were enumerated and examined sequentially in each cluster. All those with presenting vision = 50 years were enumerated, and 94.7% examined. Based on presenting vision,, 4.4% (95% Confidence Interval[CI]: 4.1,4.8) were severely visually impaired (vision<6/60 to 3/60 in the better eye) and 3.6% (95% CI: 3.3,3.9) were blind (vision<3/60 in the better eye). Prevalence of low vision (<6/18 to 6/60 in the better eye) was 16.8% (95% CI: 16.0,17.5). Prevalence of blindness and severe visual impairment (<6/60 in the better eye) was higher among rural residents (8.2%; 95% CI: 7.9,8.6) compared to urban (7.1%; 95% CI: 5.0, 9.2), among females (9.2%; 95% CI: 8.6,9.8) compared to males (6.5%; 95% CI: 6.0,7.1) and people above 70 years (20.6%; 95% CI: 19.1,22.0) compared to people aged 50-54 years (1.3%; 95% CI: 1.1,1.6). Of all blindness, 88.2% was avoidable. of which 81.9% was due to cataract and 7.1% to uncorrected refractive errors/uncorrected aphakia. CONCLUSIONS: Cataract and refractive errors are major causes of blindness and low vision and control strategies should prioritize them. Most blindness and low vision burden is avoidable

Eating Disorder Behaviors Are Increasing: Findings from Two Sequential Community Surveys in South Australia

Background: evidence for an increase in the prevalence of eating disorders is inconsistent. Our aim was to determine change in the population point prevalence of eating disorder behaviors over a 10-year period. \ud \ud Methodology/Principal Findings: eating disorder behaviors were assessed in consecutive general population surveys of men and women conducted in 1995 (n = 3001, 72% respondents) and 2005 (n = 3047, 63.1% respondents). Participants were randomly sampled from households in rural and metropolitan South Australia. There was a significant (all p,0.01) and over two-fold increase in the prevalence of binge eating, purging (self-induced vomiting and/or laxative or diuretic misuse) and strict dieting or fasting for weight or shape control among both genders. The most common diagnosis in 2005 was either binge eating disorder or other ‘‘eating\ud disorders not otherwise specified’’ (EDNOS; n = 119, 4.2%). \ud \ud Conclusions/Significance: in this population sample the point prevalence of eating disorder behaviors increased over the past decade. Cases of anorexia nervosa and bulimia nervosa, as currently defined, remain uncommon

Prevalence of Cataract Surgery and Visual Outcomes in Indian Immigrants in Singapore: The Singapore Indian Eye Study

10.1371/journal.pone.0075584PLoS ONE810-POLN

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation