Crack Growth from Naturally Occurring Material Discontinuities in Operational Aircraft

AbstractThis paper focuses on problems associated with aircraft sustainment related issues and illustrates how cracks that grow from small naturally occurring material discontinuities in operational aircraft behave. The example discussed in this paper, which is associated with crack growth under a representative maritime aircraft load spectrum, when taken in conjunction with previous studies into cracks growing under combat aircraft load spectra illustrates how for cracks that grow from naturally occurring material discontinuities under such operational load spectra there is generally little crack closure so that the crack growth history from its initial equivalent pre-crack size (EPS) through to final failure can be easily and accurately computed

Formulation development and delivery of biopesticides

Non-Peer ReviewedBiopesticide formulation development is integral for end product development and risk reduction associated with commercialization and acceptance by the end user. Development of robust formulations for biopesticides is a key step towards advancing this technology into integrated pest management systems. A granular formulation protocol using extrusion-spheronization-fluidized bed drying for biopesticidal bacteria and fungal hypha and spores is described. Establishing low granule water activity (aw, 0.2-0.3) is a key factor in extending the shelf-life of the product. Starch type and amount provided controlled release attributes to the biopesticide granules. Microencapsulation of bioherbicide, Colletotrichum truncatum 00-003B1 (Ct), conidia and bioinsecticide nucleopolyhedrovirus (NPV), by complex coacervation is described for foliar application of biocontrol agents

Simulation of the stochastic wave loads using a physical modeling approach

In analyzing stochastic dynamic systems, analysis of the system uncertainty due to randomness in the loads plays a crucial role. Typically time series of the stochastic loads are simulated using traditional random phase method. This approach combined with fast Fourier transform algorithm makes an efficient way of simulating realizations of the stochastic load processes. However it requires many random variables, i.e. in the order of magnitude of 1000, to be included in the load model. Unfortunately having too many random variables in the problem makes considerable difficulties in analyzing system reliability or its uncertainty. Moreover applicability of the probability density evolution method on engineering problems faces critical difficulties when the system embeds too many random variables. Hence it is useful to devise a method which can make realization of the stochastic load processes with low, say less than 20, number of random variables. In this article we introduce an approach, so-called "physical modeling of stochastic processes", and show its applicability for simulation of the wave surface elevation.</jats:p

Simplifying the mosaic description of DNA sequences

By using the Jensen-Shannon divergence, genomic DNA can be divided into compositionally distinct domains through a standard recursive segmentation procedure. Each domain, while significantly different from its neighbours, may however share compositional similarity with one or more distant (non--neighbouring) domains. We thus obtain a coarse--grained description of the given DNA string in terms of a smaller set of distinct domain labels. This yields a minimal domain description of a given DNA sequence, significantly reducing its organizational complexity. This procedure gives a new means of evaluating genomic complexity as one examines organisms ranging from bacteria to human. The mosaic organization of DNA sequences could have originated from the insertion of fragments of one genome (the parasite) inside another (the host), and we present numerical experiments that are suggestive of this scenario.Comment: 16 pages, 1 figure, Accepted for publication in Phys. Rev.

Use of cultivar resistance and crop rotation with Bacillus subtilis for clubroot control in canola

Non-Peer ReviewedThis study was conducted to assess additional strategies potentially complimentary to cultivar resistance or biocontrol in control of clubroot. New granular Bacillus subtilis formulations and a seed dressing method were developed to facilitate biofungicide delivery in field trials. The granular formulations were applied in furrow during seeding at 50 kg/ha to a clubroot resistant (CR) and susceptible (CS) canola cultivar, respectively, in three field trials. The seed dressing applied approximately 1×105 to 5×106 cfu/seed doses of the biocontrol agent, and was evaluated on the CS cultivar seeded to different crop-rotation scenarios where the plots had a 1-year, 3-year, or 11-year break from last canola crop. Clubroot disease pressure was high at all trial sites with disease severity indexes (DSI) ranging from 69% to 98% on the CS cultivar. None of the granular formulations reduced clubroot substantially, whereas the CR cultivar showed a high effect, reducing DSI to below 15% and doubling the yield over that of CS cultivar. Plots of varying rotation showed a pattern of clubroot pathogen pressure, with those of 1-year break from canola being the highest. The DSI for all rotational scenarios was high, reaching 100% in short-rotation plots. Biofungicide seed dressing did not reduce DSI, but longer crop rotation often reduced gall size slightly, showed much milder above-ground damage, and increased the yield significantly relative to short rotation in two separate trials. Even a 3-year break from canola was highly beneficial, with the yield doubled as opposed to that with only 1-year break from canola

Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI)

Fragile X-associated primary ovarian insufficiency (FXPOI) is among the family of disorders caused by the expansion of a CGG repeat sequence in the 5' untranslated region of the X-linked gene FMR1. About 20% of women who carry the premutation allele (55 to 200 unmethylated CGG repeats) develop hypergonadotropic hypogonadism and cease menstruating before age 40. Some proportion of those who are still cycling show hormonal profiles indicative of ovarian dysfunction. FXPOI leads to subfertility and an increased risk of medical conditions associated with early estrogen deficiency. Little progress has been made in understanding the etiology of this clinically significant disorder. Understanding the molecular mechanisms of FXPOI requires a detailed knowledge of ovarian FMR1 mRNA and FMRP's function. In humans, non-invasive methods to discriminate the mechanisms of the premutation on ovarian function are not available, thus necessitating the development of model systems. Vertebrate (mouse and rat) and invertebrate (Drosophila melanogaster) animal studies for the FMR1 premutation and ovarian function exist and have been instrumental in advancing our understanding of the disease phenotype. For example, rodent models have shown that FMRP is highly expressed in oocytes where it is important for folliculogenesis. The two premutation mouse models studied to date show evidence of ovarian dysfunction and, together, suggest that the long repeat in the transcript itself may have some pathological effect quite apart from any effect of the toxic protein. Further, ovarian morphology in young animals appears normal and the primordial follicle pool size does not differ from that of wild-type animals. However, there is a progressive premature decline in the levels of most follicle classes. Observations also include granulosa cell abnormalities and altered gene expression patterns. Further comparisons of these models are now needed to gain insight into the etiology of the ovarian dysfunction. Premutation model systems in non-human primates and those based on induced pluripotent stem cells show particular promise and will complement current models. Here, we review the characterization of the current models and describe the development and potential of the new models. Finally, we will discuss some of the molecular mechanisms that might be responsible for FXPOI

Leveraging domestic and foreign learning to develop marketing capabilities: The case of the Chinese company Goodbaby

Purpose The purpose of this paper is to explore the role of different learning sources in the process of capability building of Chinese firms (CFs) approaching international markets. Design/methodology/approach The paper is based on the case study of the company “Goodbaby.” The primary data sources are two semi-structured interviews with one of the firm’s managers, which have been triangulated with point of sale visits, interviews with industry experts, and secondary data such as corporate records, patent and trademark data, industry reports and news articles. Findings Both the home-country and foreign markets act as sources of learning to support the development of CFs’ marketing capabilities. Learning at home is triggered by the complexity of the national market and the exposure to foreign entrants. Foreign learning is stimulated by the relationships with leading foreign partners and the exposure to advanced final markets. Moreover, each learning source has a positive effect on the development of CFs’ marketing capabilities in both market contexts in which they compete, i.e. the home-market and international markets. Practical implications CFs’ managers should be simultaneously receptive to the domestic and foreign contexts, as both may support the development of marketing capabilities. CFs’ managers should recognize the learning opportunities embedded in each of these contexts, and identify the markets where these can be effectively redeployed. Originality/value The authors distinguish between different sources of learning in the context of CFs’ internationalization, and explore their triggering factors and their role in the development of an underinvestigated type of capabilities, i.e. the marketing capabilities

Heavy Quarks and Heavy Quarkonia as Tests of Thermalization

We present here a brief summary of new results on heavy quarks and heavy quarkonia from the PHENIX experiment as presented at the "Quark Gluon Plasma Thermalization" Workshop in Vienna, Austria in August 2005, directly following the International Quark Matter Conference in Hungary.Comment: 8 pages, 5 figures, Quark Gluon Plasma Thermalization Workshop (Vienna August 2005) Proceeding

Single Electrons from Heavy Flavor Decays in p+p Collisions at sqrt(s) = 200 GeV

The invariant differential cross section for inclusive electron production in p+p collisions at sqrt(s) = 200 GeV has been measured by the PHENIX experiment at the Relativistic Heavy Ion Collider over the transverse momentum range $0.4 <= p_T <= 5.0 GeV/c at midrapidity (eta <= 0.35). The contribution to the inclusive electron spectrum from semileptonic decays of hadrons carrying heavy flavor, i.e. charm quarks or, at high p_T, bottom quarks, is determined via three independent methods. The resulting electron spectrum from heavy flavor decays is compared to recent leading and next-to-leading order perturbative QCD calculations. The total cross section of charm quark-antiquark pair production is determined as sigma_(c c^bar) = 0.92 +/- 0.15 (stat.) +- 0.54 (sys.) mb.Comment: 329 authors, 6 pages text, 3 figures. Submitted to Phys. Rev. Lett. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm