Effects of propiverine and its metabolite propiverine-N-oxide on bladder contraction and salivation in mini pigs

Purpose: The objective of this study was to evaluate the influence of propiverine-HCl (P4) and propiverine-N-oxide (P4NO), one of the major metabolites of P4, on bladder contraction in a standardized in vivo model. Additionally, salivary flow measurements enabled the evaluation of hyposalivation, one of the most predominant anticholinergic side effects. Materials and Methods: Ten male mini pigs were anesthetized. P4 (0.4 mg/kg b.w.) and P4NO (0.422 mg/kg b.w.) were administered intravenously. Bladder contractions were induced through sacral anterior root stimulation and cystometrogram evaluation was performed. For stimulation-induced salivary flow measurements, the lingual nerve was exposed for neurostimulation. The effects of P4 and P4NO on stimulation-induced bladder contraction and salivation were evaluated in 5 mini pigs, respectively. Results: In all experiments, for each animal reproducible intravesical pressure values (Pves) were elicited during sacral anterior root stimulation before administration of the study drug. After administration of P4, Pves decreased by 64% whereas P4NO decreased Pves by 28%. Inhibition of salivary flow with P4 and P4NO was 71 and 32%, respectively. Directly following intravenous administration of P4, a short-term and reversible period of mild fluctuations in heart rate was observed. Administration of P4NO revealed no changes in either heart rate, or blood pressure. Conclusion: All of the investigated parameters revealed less anticholinergic effects for P4NO compared to P4. Under the experimental conditions described above, it may be assumed that P4NO behaves as a substance with poor anticholinergic effects with respect to side effects. As expected, P4 showed anticholinergic effects on bladder contraction and salivation. Copyrigh

Chiral-symmetry restoration in the linear sigma model at nonzero temperature and baryon density

We study the chiral phase transition in the linear sigma model with 2 quark flavors and $N_c$ colors. One-loop calculations predict a first-order phase transition at both $\mu=0$ and $\mu\neq 0$. We also discuss the phase diagram and make a comparison with a thermal parametrization of existing heavy-ion experimental data.Comment: 12 pages, 6 ps-figures, LaTe

Biologic Therapy for HLA-B27-associated Ocular Disorders

The treatment of articular and extra-articular manifestations associated with HLA-B27 has undergone dramatic changes over the past two decades, mainly as a consequence of the introduction of biologic agents and in particular anti-tumor necrosis factor α (anti-TNFα) agents. Uveitis is known to be the most frequent extra-articular feature in HLA-B27-associated spondyloarthritides. Topical corticosteroids and cycloplegic agents remain the cornerstones of treatment. However, biologic therapy may be effective in the management of refractory or recurrent forms of uveitis. This review gives an update on the management of HLA-B27-associated ocular disorders with biologics, including anti-TNFα agents and non-anti-TNFα biologic modifier drugs. There is an emerging role for newer biologics targeting interleukin-12/23 and interleukin-17 for the treatment of spondyloarthritides but data on their efficacy on anterior uveitis are sparse

Hexagonal dielectric resonators and microcrystal lasers

We study long-lived resonances (lowest-loss modes) in hexagonally shaped dielectric resonators in order to gain insight into the physics of a class of microcrystal lasers. Numerical results on resonance positions and lifetimes, near-field intensity patterns, far-field emission patterns, and effects of rounding of corners are presented. Most features are explained by a semiclassical approximation based on pseudointegrable ray dynamics and boundary waves. The semiclassical model is also relevant for other microlasers of polygonal geometry.Comment: 12 pages, 17 figures (3 with reduced quality

Lifetimes of electrons in the Shockley surface state band of Ag(111)

We present a theoretical many-body analysis of the electron-electron (e-e) inelastic damping rate $\Gamma$ of electron-like excitations in the Shockley surface state band of Ag(111). It takes into account ab-initio band structures for both bulk and surface states. $\Gamma$ is found to increase more rapidly as a function of surface state energy E than previously reported, thus leading to an improved agreement with experimental data

Vibrations of a chain of Xe atoms in a groove of carbon nanotube bundle

We present a lattice dynamics study of the vibrations of a linear chain of Xe adsorbates in groove positions of a bundle of carbon nanotubes. The characteristic phonon frequencies are calculated and the adsorbate polarization vectors discussed. Comparison of the present results with the ones previously published shows that the adsorbate vibrations cannot be treated as completely decoupled from the vibrations of carbon nanotubes and that a significant hybridization between the adsorbate and the tube modes occurs for phonons of large wavelengths.Comment: 3 PS figure

Double-Scaling Limit of Heterotic Bundles and Dynamical Deformation in CFT

We consider heterotic string theory on Eguchi-Hanson space, as a local model of a resolved A_1 singularity in a six-dimensional flux compactification, with an Abelian gauge bundle turned on and non-zero torsion. We show that in a suitable double scaling limit, that isolates the physics near the non-vanishing two-cycle, a worldsheet conformal field theory description can be found. It contains a heterotic coset whose target space is conformal to Eguchi-Hanson. Starting from the blow-down limit of the singularity, it can be viewed as a dynamical deformation of the near-horizon fivebrane background. We analyze in detail the spectrum of the theory in particular examples, as well as the important role of worldsheet non-perturbative effects.Comment: 45 pages, no figures; ver2: typos corrected, references added, an extra tadpole-free model covere

Electroproduction of two light vector mesons in next-to-leading BFKL: study of systematic effects

The forward electroproduction of two light vector mesons is the first example of a collision process between strongly interacting colorless particles for which the amplitude can be written completely within perturbative QCD in the Regge limit with next-to-leading accuracy. In a previous paper we have given a numerical determination of the amplitude in the case of equal photon virtualities by using a definite representation for the amplitude and a definite optimization method for the perturbative series. Here we estimate the systematic uncertainty of our previous determination, by considering a different representation of the amplitude and different optimization methods of the perturbative series. Moreover, we compare our result for the differential cross section at the minimum momentum transfer with a different approach, based on collinear kernel improvement.Comment: 17 pages, 11 figures; journal version, new figures and discussion adde

Influence of a Uniform Current on Collective Magnetization Dynamics in a Ferromagnetic Metal

We discuss the influence of a uniform current, $\vec{j}$, on the magnetization dynamics of a ferromagnetic metal. We find that the magnon energy $\epsilon(\vec{q})$ has a current-induced contribution proportional to $\vec{q}\cdot \vec{\cal J}$, where $\vec{\cal J}$ is the spin-current, and predict that collective dynamics will be more strongly damped at finite ${\vec j}$. We obtain similar results for models with and without local moment participation in the magnetic order. For transition metal ferromagnets, we estimate that the uniform magnetic state will be destabilized for $j \gtrsim 10^{9} {\rm A} {\rm cm}^{-2}$. We discuss the relationship of this effect to the spin-torque effects that alter magnetization dynamics in inhomogeneous magnetic systems.Comment: 12 pages, 2 figure