933 research outputs found
Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice.
Darwin Tames an Andromeda Dwarf: Unraveling the Orbit of NGC 205 Using a Genetic Algorithm
NGC 205, a close satellite of the M31 galaxy, is our nearest example of a
dwarf elliptical galaxy. Photometric and kinematic observations suggest that
NGC 205 is undergoing tidal distortion from its interaction with M31. Despite
earlier attempts, the orbit and progenitor properties of NGC 205 are not well
known. We perform an optimized search for these unknowns by combining a genetic
algorithm with restricted N-body simulations of the interaction. This approach,
coupled with photometric and kinematic observations as constraints, allows for
an effective exploration of the parameter space. We represent NGC 205 as a
static Hernquist potential with embedded massless test particles that serve as
tracers of surface brightness. We explore 3 distinct, initially stable
configurations of test particles: cold rotating disk, warm rotating disk, and
hot, pressure-supported spheroid. Each model reproduces some, but not all, of
the observed features of NGC 205, leading us to speculate that a rotating
progenitor with substantial pressure support could match all of the
observables. Furthermore, plausible combinations of mass and scale length for
the pressure-supported spheroid progenitor model reproduce the observed
velocity dispersion profile. For all 3 models, orbits that best match the
observables place the satellite 11+/-9 kpc behind M31 moving at very large
velocities: 300-500 km/s on primarily radial orbits. Given that the observed
radial component is only 54 km/s, this implies a large tangential motion for
NGC 205, moving from the NW to the SE. These results suggest NGC 205 is not
associated with the stellar arc observed to the NE of NGC 205. Furthermore, NGC
205's velocity appears to be near or greater than its escape velocity,
signifying that the satellite is likely on its first M31 passage.Comment: 34 pages, 20 figures, accepted for publication in the Astrophysical
Journal, A pdf version with high-resolution figures may be obtained from
http://www.ucolick.org/~kirsten/ms.pd
Can re-entrance be observed in force induced transitions?
A large conformational change in the reaction co-ordinate and the role of the
solvent in the formation of base-pairing are combined to settle a long standing
issue {\it i.e.} prediction of re-entrance in the force induced transition of
DNA. A direct way to observe the re-entrance, i.e a strand goes to the closed
state from the open state and again to the open state with temperature, appears
difficult to be achieved in the laboratory. An experimental protocol (in direct
way) in the constant force ensemble is being proposed for the first time that
will enable the observation of the re-entrance behavior in the
force-temperature plane. Our exact results for small oligonucleotide that forms
a hairpin structure provide the evidence that re-entrance can be observed.Comment: 12 pages and 5 figures (RevTex4). Accepted in Europhys Lett. (2009
Specific chromosomal abnormalities characterize fibrosarcomas of bovine papillomavirus type 1 transgenic mice.
Itâs Not All about the Economy Stupid! Immigration and Subjective Well-Being in England
While much is known regarding the effects of immigration for objective outcomes, relatively little is known regarding the effects for perceived well-being. By exploiting spatial and temporal variation in the net-inflows of foreign-born individuals across local areas in England, we examine the relationship between immigration and nativesâ subjective well-being as captured by the General Health Questionnaire (GHQ). We find small negative effects overall but that an analysis of the main effects masks significant differences across subgroups, with relatively older individuals, those with below-average household incomes, the unemployed and finally those without any formal educational qualifications experiencing much more substantive well-being losses than others. These observed well-being differentials are congruent with voting patterns evident in the recent UK referendum on EU membership. We put forward perceived as opposed to actual labour market competition and social identity as two potential explanations for the negative well-being impacts of immigration for natives
Internal Stellar Kinematics of M32 from the SPLASH Survey: Dark Halo Constraints
As part of the SPLASH survey of the Andromeda (M31) system, we have obtained Keck/DEIMOS spectra of the compact elliptical (cE) satellite M32. This is the first resolved-star kinematical study of any cE galaxy. In contrast to most previous kinematical studies that extended out to râŸ30" ~ 1 r^(eff) I ~ 100 pc, we measure the rotation curve and velocity dispersion profile out to r ~ 250" and higher order Gauss-Hermite moments out to r ~ 70". We achieve this by combining integrated-light spectroscopy at small radii (where crowding/blending are severe) with resolved stellar spectroscopy at larger radii, using spatial and kinematical information to account statistically for M31 contamination. The rotation curve and velocity dispersion profile extend well beyond the radius (r ~ 150") where the isophotes are distorted. Unlike NGC 205, another close dwarf companion of M31, M32's kinematics appear regular and symmetric and do not show obvious sharp gradients across the region of isophotal elongation and twists. We interpret M31's kinematics using three-integral axisymmetric dynamical equilibrium models constructed using Schwarzschild's orbit superposition technique. Models with a constant mass-to-light ratio can fit the data remarkably well. However, since such a model requires an increasing tangential anisotropy with radius, invoking the presence of an extended dark halo may be more plausible. Such an extended dark halo is definitely required to bind a half-dozen fast-moving stars observed at the largest radii, but these stars may not be an equilibrium component of M32
Polymerase chain reaction detection of avipox and avian papillomavirus in naturally infected wild birds: comparisons of blood, swab and tissue samples
Avian poxvirus (avipox) is widely reported from avian species, causing cutaneous or mucosal lesions. Mortality rates of up to 100% are recorded in some hosts. Three major avipox clades are recognized. Several diagnostic techniques have been reported, with molecular techniques used only recently. Avipox has been reported from 278 different avian species, but only 111 of these involved sequence and/or strain identification. Collecting samples from wild birds is challenging as only few wild bird individuals or species may be symptomatic. Also, sampling regimes are tightly regulated and the most efficient sampling method, whole bird collection, is ethically challenging. In this study, three alternative sampling techniques (blood, cutaneous swabs and tissue biopsies) from symptomatic wild birds were examined. Polymerase chain reaction was used to detect avipoxvirus and avian papillomavirus (which also induces cutaneous lesions in birds). Four out of 14 tissue samples were positive but all 29 blood samples and 22 swab samples were negative for papillomavirus. All 29 blood samples were negative but 6/22 swabs and 9/14 tissue samples were avipox-positive. The difference between the numbers of positives generated from tissue samples and from swabs was not significant. The difference in the avipox-positive specimens in paired swab (4/6) and tissue samples (6/6) was also not significant. These results therefore do not show the superiority of swab or tissue samples over each other. However, both swab (6/22) and tissue (8/9) samples yielded significantly more avipox-positive cases than blood samples, which are therefore not recommended for sampling these viruses.The authors thank bird ringers from Alula and Monticola, especially Alfredo Ortega and Chechu Aguirre, for help with the capture and ringing of birds, which made this project possible. Thanks to Alvaro RamĂrez for samples. This research was funded by the Ministerio de Ciencia e InnovaciĂłn, Spain (grant number: CGL2010-15734/BOS). R.A.J.W. was supported by the Programa Internacional de CaptaciĂłn de Talento (PICATA) de Moncloa Campus de Excelencia Internacional while writing the manuscript
Who Needs Good Neighbours?
Abstract: Due to the increasing spatial dispersion of social networks, the association between neighbor relationships and quality of life has become more uncertain. Our analysis used instrumental variable modelling to reduce bias associated with residual confounding and reverse causation, in order to provide a more reliable examination of the effect of interaction with neighbors on subjective well-being than previous work. While the frames of reference for individualsâ socializing may have shifted outside the neighborhood, our analysis provides robust evidence that interaction with neighbors still matters a great deal for subjective well-being. A further important question to ask is if neighboring does affect well-being, then are there certain groups in society for whom contact with neighbors matters more? Our analysis suggests that there are, namely for those in a relationship, unemployed or retired. This means that while fostering contact with neighbors has the potential to significantly improve individual well-being, such policy efforts are likely to matter a good deal more in neighborhoods with relatively large numbers of geographically constrained social groups, such as the elderly and the unemployed. Key words: subjective well-being, neighborly interaction, social capita
Local Group Dwarf Elliptical Galaxies: II. Stellar Kinematics to Large Radii in NGC 147 and NGC 185
We present kinematic and metallicity profiles for the M31 dwarf elliptical
(dE) satellite galaxies NGC 147 and NGC 185. The profiles represent the most
extensive spectroscopic radial coverage for any dE galaxy, extending to a
projected distance of eight half-light radii (8 r_eff = 14'). We achieve this
coverage via Keck/DEIMOS multislit spectroscopic observations of 520 and 442
member red giant branch stars in NGC 147 and NGC 185, respectively. In contrast
to previous studies, we find that both dEs have significant internal rotation.
We measure a maximum rotational velocity of 17+/-2 km/s for NGC 147 and 15+/-5
km/s for NGC 185. The velocity dispersions decrease gently with radius with an
average dispersion of 16+/-1 km/s for NGC 147 and 24+/-1 km/s for NGC 185. Both
dEs have internal metallicity dispersions of 0.5 dex, but show no evidence for
a radial metallicity gradient. We construct two-integral axisymmetric dynamical
models and find that the observed kinematical profiles cannot be explained
without modest amounts of non-baryonic dark matter. We measure central
mass-to-light ratios of ML_V = 4.2+/-0.6 and ML_V = 4.6+/-0.6 for NGC 147 and
NGC 185, respectively. Both dE galaxies are consistent with being primarily
flattened by their rotational motions, although some anisotropic velocity
dispersion is needed to fully explain their observed shapes. The velocity
profiles of all three Local Group dEs (NGC 147, NGC 185 and NGC 205) suggest
that rotation is more prevalent in the dE galaxy class than previously assumed,
but is often manifest only at several times the effective radius. Since all dEs
outside the Local Group have been probed to only inside the effective radius,
this opens the door for formation mechanisms in which dEs are transformed or
stripped versions of gas-rich rotating progenitor galaxies.Comment: 16 pages, 7 figures. accepted to A
AluminiumâCatalyzed C(sp)âH Borylation of Alkynes
Historically used in stoichiometric hydroalumination chemistry, recent advances have transformed aluminium hydrides into versatile catalysts for the hydroboration of unsaturated multiple bonds. This catalytic ability is founded on the defining reactivity of aluminium hydrides with alkynes and alkenes: 1,2âhydroalumination of the unsaturated Ïâsystem. This manuscript reports the aluminium hydride catalyzed dehydroborylation of terminal alkynes. A tethered intramolecular amine ligand controls reactivity at the aluminium hydride centre, switching off hydroalumination and instead enabling selective reactions at the alkyne CâH Ïâbond. Chemoselective CâH borylation was observed across a series of arylâ and alkylâsubstituted alkynes (21 examples). On the basis of kinetic and density functional theory studies, a mechanism in which CâH borylation proceeds by Ïâbond metathesis between pinacolborane (HBpin) and alkynyl aluminium intermediates is proposed
- âŠ