2,572 research outputs found
On the design of an interactive biosphere for the GLAS general circulation model
Improving the realism and accuracy of the GLAS general circulation model (by adding an interactive biosphere that will simulate the transfers of latent and sensible heat from land surface to atmosphere as functions of the atmospheric conditions and the morphology and physiology of the vegetation) is proposed
Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells
It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells. Using bioinformatics analysis and functional screening, we screened short-activating RNA (saRNA) oligonucleotides designed to target the promoter regions of the pluripotency reprogramming factors, Kruppel-like factor 4 (KLF4) and c-MYC. We identified KLF4 and c-MYC promoter-targeted saRNA sequences that consistently induced increases in their respective levels of nascent mRNA and protein expression in a time- and dose-dependent manner, as compared with scrambled sequence control oligonucleotides. The functional consequences of saRNA-induced activation of each targeted reprogramming factor were then characterized by comprehensively profiling changes in gene expression by microarray analysis, which revealed significant increases in mRNA levels of their respective downstream pathway genes. Notably, the microarray profile after saRNA-mediated induction of endogenous KLF4 and c-MYC showed similar gene expression patterns for stem cell- and cell cycle-related genes as compared with lentiviral vector-mediated overexpression of exogenous KLF4 and c-MYC transgenes, while divergent gene expression patterns common to viral vector-mediated transgene delivery were also noted. The use of promoter-targeted saRNAs for the activation of pluripotency reprogramming factors could have broad implications for stem cell research
A Virtual Conversational Agent for Teens with Autism: Experimental Results and Design Lessons
We present the design of an online social skills development interface for
teenagers with autism spectrum disorder (ASD). The interface is intended to
enable private conversation practice anywhere, anytime using a web-browser.
Users converse informally with a virtual agent, receiving feedback on nonverbal
cues in real-time, and summary feedback. The prototype was developed in
consultation with an expert UX designer, two psychologists, and a pediatrician.
Using the data from 47 individuals, feedback and dialogue generation were
automated using a hidden Markov model and a schema-driven dialogue manager
capable of handling multi-topic conversations. We conducted a study with nine
high-functioning ASD teenagers. Through a thematic analysis of post-experiment
interviews, identified several key design considerations, notably: 1) Users
should be fully briefed at the outset about the purpose and limitations of the
system, to avoid unrealistic expectations. 2) An interface should incorporate
positive acknowledgment of behavior change. 3) Realistic appearance of a
virtual agent and responsiveness are important in engaging users. 4)
Conversation personalization, for instance in prompting laconic users for more
input and reciprocal questions, would help the teenagers engage for longer
terms and increase the system's utility
Strangeness in Astrophysics and Cosmology
Some recent developments concerning the role of strange quark matter for
astrophysical systems and the QCD phase transition in the early universe are
addressed. Causality constraints of the soft nuclear equation of state as
extracted from subthreshold kaon production in heavy-ion collisions are used to
derive an upper mass limit for compact stars. The interplay between the
viscosity of strange quark matter and the gravitational wave emission from
rotation-powered pulsars are outlined. The flux of strange quark matter nuggets
in cosmic rays is put in perspective with a detailed numerical investigation of
the merger of two strange stars. Finally, we discuss a novel scenario for the
QCD phase transition in the early universe, which allows for a small
inflationary period due to a pronounced first order phase transition at large
baryochemical potential.Comment: 8 pages, invited talk given at the International Conference on
Strangeness in Quark Matter (SQM2009), Buzios, Brasil, September 28 - October
2, 200
Strange quark matter in explosive astrophysical systems
Explosive astrophysical systems, such as supernovae or compact star binary
mergers, provide conditions where strange quark matter can appear. The high
degree of isospin asymmetry and temperatures of several MeV in such systems may
cause a transition to the quark phase already around saturation density.
Observable signals from the appearance of quark matter can be predicted and
studied in astrophysical simulations. As input in such simulations, an equation
of state with an integrated quark matter phase transition for a large
temperature, density and proton fraction range is required. Additionally,
restrictions from heavy ion data and pulsar observation must be considered. In
this work we present such an approach. We implement a quark matter phase
transition in a hadronic equation of state widely used for astrophysical
simulations and discuss its compatibility with heavy ion collisions and pulsar
data. Furthermore, we review the recently studied implications of the QCD phase
transition during the early post-bounce evolution of core-collapse supernovae
and introduce the effects from strong interactions to increase the maximum mass
of hybrid stars. In the MIT bag model, together with the strange quark mass and
the bag constant, the strong coupling constant provides a parameter
to set the beginning and extension of the quark phase and with this the mass
and radius of hybrid stars.Comment: 6 pages, 5 figures, talk given at the International Conference on
Strangeness in Quark Matter (SQM2009), Buzios, Brasil, September 28 - October
2, 2009, to be published in Journal Phys.
Smoke gets in your eyes:what is sociological about cigarettes?
Contemporary public health approaches increasingly draw attention to the unequal social distribution of cigarette smoking. In contrast, critical accounts emphasize the importance of smokers’ situated agency, the relevance of embodiment and how public health measures against smoking potentially play upon and exacerbate social divisions and inequality. Nevertheless, if the social context of cigarettes is worthy of such attention, and sociology lays a distinct claim to understanding the social, we need to articulate a distinct, positive and systematic claim for smoking as an object of sociological enquiry. This article attempts to address this by situating smoking across three main dimensions of sociological thinking: history and social change; individual agency and experience; and social structures and power. It locates the emergence and development of cigarettes in everyday life within the project of modernity of the nineteenth and twentieth centuries. It goes on to assess the habituated, temporal and experiential aspects of individual smoking practices in everyday lifeworlds. Finally, it argues that smoking, while distributed in important ways by social class, also works relationally to render and inscribe it
Exchange Current Corrections to Neutrino--Nucleus Scattering
Relativistic exchange current corrections to neutrino--nucleus cross sections
are presented assuming non--vanishing strange quark form factors for the
constituent nucleons. For charged current processes the exchange current
corrections can lower the impulse approximation results by 10\% while these
corrections are found to be sensitive to both the nuclear density and the
strange quark axial form factor of the nucleon for neutral current processes.
Implications on the LSND experiment to determine this form factor are
discussed.Comment: 11 pages, 2 figures, revtex 3.0, full postscript version of the file
and figures available at
http://www.nikhefk.nikhef.nl/projects/Theory/preprints/preprints.html To
appear in Phys. Rev. Lett
Simulation of a Lunar Surface Base Power Distribution Network for the Constellation Lunar Surface Systems
The Lunar Surface Power Distribution Network Study team worked to define, breadboard, build and test an electrical power distribution system consistent with NASA's goal of providing electrical power to sustain life and power equipment used to explore the lunar surface. A testbed was set up to simulate the connection of different power sources and loads together to form a mini-grid and gain an understanding of how the power systems would interact. Within the power distribution scheme, each power source contributes to the grid in an independent manner without communication among the power sources and without a master-slave scenario. The grid consisted of four separate power sources and the accompanying power conditioning equipment. Overall system design and testing was performed. The tests were performed to observe the output and interaction of the different power sources as some sources are added and others are removed from the grid connection. The loads on the system were also varied from no load to maximum load to observe the power source interactions
Comparison of SGA Oral Medications and a Long-Acting Injectable SGA: The PROACTIVE Study
Until relatively recently, long-acting injectable (LAI) formulations were only available for first-generation antipsychotics and their utilization decreased as use of oral second-generation antipsychotics (SGA) increased. Although registry-based naturalistic studies show LAIs reduce rehospitalization more than oral medications in clinical practice, this is not seen in recent randomized clinical trials. PROACTIVE (Preventing Relapse Oral Antipsychotics Compared to Injectables Evaluating Efficacy) relapse prevention study incorporated efficacy and effectiveness features. At 8 US academic centers, 305 patients with schizophrenia or schizoaffective disorder were randomly assigned to LAI risperidone (LAI-R) or physician\u27s choice oral SGAs. Patients were evaluated during the 30-month study by masked, centralized assessors using 2-way video, and monitored biweekly by on-site clinicians and assessors who knew treatment assignment. Relapse was evaluated by a masked Relapse Monitoring Board. Differences between LAI-R and oral SGA treatment in time to first relapse and hospitalization were not significant. Psychotic symptoms and Brief Psychiatric Rating Scale total score improved more in the LAI-R group. In contrast, the LAI group had higher Scale for Assessment of Negative Symptoms Alogia scale scores. There were no other between-group differences in symptoms or functional improvement. Despite the advantage for psychotic symptoms, LAI-R did not confer an advantage over oral SGAs for relapse or rehospitalization. Biweekly monitoring, not focusing specifically on patients with demonstrated nonadherence to treatment and greater flexibility in changing medication in the oral treatment arm, may contribute to the inability to detect differences between LAI and oral SGA treatment in clinical trials
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