Diffractive parton distributions from the saturation model

We review diffractive deep inelastic scattering (DIS) in the light of the collinear factorization theorem. This theorem allows to define diffractive parton distributions in the leading twist approach. Due to its selective final states, diffractive DIS offers interesting insight into the form of the diffractive parton distributions which we explore with the help of the saturation model. We find Regge-like factorization with the correct energy dependence measured at HERA. A remarkable feature of diffractive DIS is the dominance of the twist-4 contribution for small diffractive masses. We quantify this effect and make a comparison with the data.Comment: 18 pages, 6 figures, latex, Q_0^2 corrected in comparison to the journal versio

Does coffee protect against hepatocellular carcinoma?

We analysed the relation between coffee consumption and hepatocellular carcinoma in two case-control studies conducted between 1984 and 1998 in Italy and Greece, including 834 cases and 1912 controls. Compared to non coffee drinkers, the multivariate odds ratio was 0.7 for drinkers of three or more cups per day

Quantifying and Interpreting Connection Strength in Macroand Microscopic Systems: Lessons from Bell’s Approach

Bell inequalities were created with the goal of improving the understanding of foundational questions in quantum mechanics. To this end, they are typically applied to measurement results generated from entangled systems of particles. They can, however, also be used as a statistical tool for macroscopic systems, where they can describe the connection strength between two components of a system under a causal model. We show that, in principle, data from macroscopic observations analyzed with Bell’ s approach can invalidate certain causal models. To illustrate this use, we describe a macroscopic game setting, without a quantum mechanical measurement process, and analyze it using the framework of Bell experiments. In the macroscopic game, violations of the inequalities can be created by cheating with classically defined strategies. In the physical context, the meaning of violations is less clear and is still vigorously debated. We discuss two measures for optimal strategies to generate a given statistic that violates the inequalities. We show their mathematical equivalence and how they can be computed from CHSH-quantities alone, if non-signaling applies. As a macroscopic example from the financial world, we show how the unfair use of insider knowledge could be picked up using Bell statistics. Finally, in the discussion of realist interpretations of quantum mechanical Bell experiments, cheating strategies are often expressed through the ideas of free choice and locality. In this regard, violations of free choice and locality can be interpreted as two sides of the same coin, which underscores the view that the meaning these terms are given in Bell’s approach should not be confused with their everyday use. In general, we conclude that Bell’s approach also carries lessons for understanding macroscopic systems of which the connectedness conforms to different causal structures

Older Adults’ Access to Care during the COVID-19 Pandemic: Results from the LOckdown and LifeSTyles (LOST) in Lombardia Project

The COVID-19 pandemic disproportionally affected older people in terms of clinical outcomes and care provision. We aimed to investigate older adults’ changes in access to care during the pandemic and their determinants. We used data from a cross-sectional study (LOST in Lombardia) conducted in autumn 2020 on a representative sample of 4400 older adults from the most populated region in Italy. Lifestyles, mental health, and access to healthcare services before and during the pandemic were collected. To identify factors associated with care delays, reduction in emergency department (ED) access, and hospitalisations, we estimated prevalence ratios (PR) and 95% confidence intervals (CI) using multivariable log-binomial regression models. During the pandemic, compared to the year before, 21.5% of the study population increased telephone contacts with the general practitioner (GP) and 9.6% increased self-pay visits, while 22.4% decreased GP visits, 12.3% decreased outpatient visits, 9.1% decreased diagnostic exams, 7.5% decreased ED access, and 6% decreased hospitalisations. The prevalence of care delays due to patient’s decision (overall 23.8%) was higher among men (PR 1.16, 95% CI 1.05–1.29), subjects aged 75 years or more (PR 1.12, 95% CI 1.00–1.25), and those with a higher economic status (p for trend < 0.001). Participants with comorbidities more frequently cancelled visits and reduced ED access or hospitalisations, while individuals with worsened mental health status reported a higher prevalence of care delays and ED access reductions. Access to care decreased in selected sub-groups of older adults during the pandemic with likely negative impacts on mortality and morbidity in the short and long run

Cigarette tar yield and risk of upper digestive tract cancers: case-control studies from Italy and Switzerland

Background: Tobacco smoking is one of the main risk factors for oral, pharyngeal and oesophageal cancers in developed countries. Information on the role of the tar yield of cigarettes in upper digestive tract carcinogenesis is sparse and needs to be updated because the tar yield of cigarettes has steadily decreased over the last few decades. Patients and methods: We analysed two case-control studies, from Italy and Switzerland, conducted between 1992 and 1999, involving 749 cases of oral and pharyngeal cancer and 1770 controls, and 395 cases of squamous-cell oesophageal carcinoma and 1066 matched controls. Odds ratios (ORs) were estimated by unconditional multiple logistic regression models, including terms for age, sex, study centre, education and alcohol consumption. Results: Based on the brand of cigarettes smoked for the longest time, the multivariate ORs for current smokers compared with never smokers were 6.1 for <20 mg and 9.8 for ≥20 mg tar for oral and pharyngeal neoplasms, and 4.8 and 5.4 for oesophageal cancer, respectively. For the cigarette brand smoked in the previous six months, the ORs for ≥10 mg compared with <10 mg were 1.9 for cancer of the oral cavity and pharynx and 1.8 for oesophageal cancer, after allowance for number of cigarettes and duration of smoking. Conclusions: The present study confirms the direct relationship between the tar yield of cigarettes and upper digestive tract neoplasms, and provides innovative information on lower tar cigarettes, which imply reduced risks compared with higher tar ones. However, significant excess risks were observed even in the lower tar category, thus giving unequivocal indications for stopping smoking as a priority for prevention of upper digestive tract neoplasm

Violations of locality and free choice are equivalent resources in Bell experiments

Bell inequalities rest on three fundamental assumptions: realism, locality, and free choice, which lead to nontrivial constraints on correlations in very simple experiments. If we retain realism, then violation of the inequalities implies that at least one of the remaining two assumptions must fail, which can have profound consequences for the causal explanation of the experiment. We investigate the extent to which a given assumption needs to be relaxed for the other to hold at all costs, based on the observation that a violation need not occur on every experimental trial, even when describing correlations violating Bell inequalities. How often this needs to be the case determines the degree of, respectively, locality or free choice in the observed experimental behavior. Despite their disparate character, we show that both assumptions are equally costly. Namely, the resources required to explain the experimental statistics (measured by the frequency of causal interventions of either sort) are exactly the same. Furthermore, we compute such defined measures of locality and free choice for any nonsignaling statistics in a Bell experiment with binary settings, showing that it is directly related to the amount of violation of the so-called Clauser–Horne–Shimony–Holt inequalities. This result is theory independent as it refers directly to the experimental statistics. Additionally, we show how the local fraction results for quantum-mechanical frameworks with infinite number of settings translate into analogous statements for the measure of free choice we introduce. Thus, concerning statistics, causal explanations resorting to either locality or free choice violations are fully interchangeable

Impact of Scottish smoke-free legislation on smoking quit attempts and prevalence

&lt;p&gt;&lt;b&gt;Objectives:&lt;/b&gt; In Scotland, legislation was implemented in March 2006 prohibiting smoking in all wholly or partially enclosed public spaces. We investigated the impact on attempts to quit smoking and smoking prevalence.&lt;/p&gt; &lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; We performed time series models using Box-Jenkins autoregressive integrated moving averages (ARIMA) on monthly data on the gross ingredient cost of all nicotine replacement therapy (NRT) prescribed in Scotland in 2003–2009, and quarterly data on self-reported smoking prevalence between January 1999 and September 2010 from the Scottish Household Survey.&lt;/p&gt; &lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; NRT prescription costs were significantly higher than expected over the three months prior to implementation of the legislation. Prescription costs peaked at £1.3 million in March 2006; £292,005.9 (95% CI £260,402.3, £323,609, p&#60;0.001) higher than the monthly norm. Following implementation of the legislation, costs fell exponentially by around 26% per month (95% CI 17%, 35%, p&#60;0.001). Twelve months following implementation, the costs were not significantly different to monthly norms. Smoking prevalence fell by 8.0% overall, from 31.3% in January 1999 to 23.7% in July–September 2010. In the quarter prior to implementation of the legislation, smoking prevalence fell by 1.7% (95% CI 2.4%, 1.0%, p&#60;0.001) more than expected from the underlying trend.&lt;/p&gt; &lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Quit attempts increased in the three months leading up to Scotland's smoke-free legislation, resulting in a fall in smoking prevalence. However, neither has been sustained suggesting the need for additional tobacco control measures and ongoing support.&lt;/p&gt

Bell correlations outside physics

Correlations are ubiquitous in nature and their principled study is of paramount importance in scientific development. The seminal contributions from John Bell offer a framework for analyzing the correlations between the components of quantum mechanical systems and have instigated an experimental tradition which has recently culminated with the Nobel Prize in Physics (2022). In physics, Bell’s framework allows the demonstration of the non-classical nature of quantum systems just from the analysis of the observed correlation patterns. Bell’s ideas need not be restricted to physics. Our contribution is to show an example of a Bell approach, based on the insight that correlations can be broken down into a part due to common, ostensibly significant causes, and a part due to noise. We employ data from finance (price changes of securities) as an example to demonstrate our approach, highlighting several general applications: first, we demonstrate a new measure of association, informed by the assumed causal relationship between variables. Second, our framework can lead to streamlined Bell-type tests of widely employed models of association, which are in principle applicable to any discipline. In the area of finance, such models of association are Factor Models and the bivariate Gaussian model. Overall, we show that Bell’s approach and the models we consider are applicable as general statistical techniques, without any domain specificity. We hope that our work will pave the way for extending our general understanding for how the structure of associations can be analyzed

Coffee consumption and prostate cancer risk: further evidence for inverse relationship

<p>Abstract</p> <p>Background</p> <p>Higher consumption of coffee intake has recently been linked with reduced risk of aggressive prostate cancer (PC) incidence, although meta-analysis of other studies that examine the association between coffee consumption and overall PC risk remains inconclusive. Only one recent study investigated the association between coffee intake and grade-specific incidence of PC, further evidence is required to understand the aetiology of aggressive PCs. Therefore, we conducted a prospective study to examine the relationship between coffee intake and overall as well as grade-specific PC risk.</p> <p>Methods</p> <p>We conducted a prospective cohort study of 6017 men who were enrolled in the Collaborative cohort study in the UK between 1970 and 1973 and followed up to 31st December 2007. Cox Proportional Hazards Models were used to evaluate the association between coffee consumption and overall, as well as Gleason grade-specific, PC incidence.</p> <p>Results</p> <p>Higher coffee consumption was inversely associated with risk of high grade but not with overall risk of PC. Men consuming 3 or more cups of coffee per day experienced 55% lower risk of high Gleason grade disease compared with non-coffee drinkers in analysis adjusted for age and social class (HR 0.45, 95% CI 0.23-0.90, p value for trend 0.01). This association changed a little after additional adjustment for Body Mass Index, smoking, cholesterol level, systolic blood pressure, tea intake and alcohol consumption.</p> <p>Conclusion</p> <p>Coffee consumption reduces the risk of aggressive PC but not the overall risk.</p