660 research outputs found

    The Rwandan genocide and the bestiality of representation in 100 Days (2001) and Shooting Dogs (2005)

    Get PDF
    Copyright © 2010 Intellect Ltd. This article is available open access at the below link.The 1994 Rwandan genocide has been a subject of filmic representation in and outside Africa. This article examines two examples of this portrayal and attempts to put them in the context of western perception of African conflict and suffering and its depiction in feature-length fictionalized films. A close analysis of 100 Days (Nick Hughes, UK/Rwanda) and Shooting Dogs (Michael Caton-Jones, UK/Germany), accompanied by cited interviews with their directors, aims to examine the mechanism of the representation of otherness in a situation when the term others is not a straightforward antonym to us. The argument revolves around the idea that others are always a group defined by a common characteristic (the colour of their skin, cultural identity or suffering), while us consists of individuals whose major qualifying feature is the fact that he or she is, individually and collectively, not like others. Special attention is paid to the difference between formal and character-based othering, as well as to the films' adhesion to western cinematic genres. The consideration is contextualized by the concept of the bestiality of representation, which becomes a manner of positioning an event within a socio-historical and individually cognitive context and determining the dynamic among the experience lived, the experience seen and objectivity. Lastly, the article looks at how the circumstances of the production process directly influence the stylistic and aesthetic choices made in films about the Rwandan genocide. In this, it relies on the examination of the trichotomy of politics, representation and the politics of representation

    Stretching of proteins in a uniform flow

    Full text link
    Stretching of a protein by a fluid flow is compared to that in a force-clamp apparatus. The comparison is made within a simple topology-based dynamical model of a protein in which the effects of the flow are implemented using Langevin dynamics. We demonstrate that unfolding induced by a uniform flow shows a richer behavior than that in the force clamp. The dynamics of unfolding is found to depend strongly on the selection of the amino acid, usually one of the termini, which is anchored. These features offer potentially wider diagnostic tools to investigate structure of proteins compared to experiments based on the atomic force microscopy.Comment: J. Chem. Phys. (in press

    Nanoindentation of virus capsids in a molecular model

    Full text link
    A molecular-level model is used to study the mechanical response of empty cowpea chlorotic mottle virus (CCMV) and cowpea mosaic virus (CPMV) capsids. The model is based on the native structure of the proteins that consitute the capsids and is described in terms of the C-alpha atoms. Nanoindentation by a large tip is modeled as compression between parallel plates. Plots of the compressive force versus plate separation for CCMV are qualitatively consistent with continuum models and experiments, showing an elastic region followed by an irreversible drop in force. The mechanical response of CPMV has not been studied, but the molecular model predicts an order of magnitude higher stiffness and a much shorter elastic region than for CCMV. These large changes result from small structural changes that increase the number of bonds by only 30% and would be difficult to capture in continuum models. Direct comparison of local deformations in continuum and molecular models of CCMV shows that the molecular model undergoes a gradual symmetry breaking rotation and accommodates more strain near the walls than the continuum model. The irreversible drop in force at small separations is associated with rupturing nearly all of the bonds between capsid proteins in the molecular model while a buckling transition is observed in continuum models.Comment: 18 figure

    Energy landscapes, supergraphs, and "folding funnels" in spin systems

    Full text link
    Dynamical connectivity graphs, which describe dynamical transition rates between local energy minima of a system, can be displayed against the background of a disconnectivity graph which represents the energy landscape of the system. The resulting supergraph describes both dynamics and statics of the system in a unified coarse-grained sense. We give examples of the supergraphs for several two dimensional spin and protein-related systems. We demonstrate that disordered ferromagnets have supergraphs akin to those of model proteins whereas spin glasses behave like random sequences of aminoacids which fold badly.Comment: REVTeX, 9 pages, two-column, 13 EPS figures include

    Coarse grained description of the protein folding

    Full text link
    We consider two- and three-dimensional lattice models of proteins which were characterized previously. We coarse grain their folding dynamics by reducing it to transitions between effective states. We consider two methods of selection of the effective states. The first method is based on the steepest descent mapping of states to underlying local energy minima and the other involves an additional projection to maximally compact conformations. Both methods generate connectivity patterns that allow to distinguish between the good and bad folders. Connectivity graphs corresponding to the folding funnel have few loops and are thus tree-like. The Arrhenius law for the median folding time of a 16-monomer sequence is established and the corresponding barrier is related to easily identifiable kinetic trap states.Comment: REVTeX, 9 pages, 15 EPS figures, to appear in Phys. Rev.

    Delineation of the Native Basin in Continuum Models of Proteins

    Get PDF
    We propose two approaches for determining the native basins in off-lattice models of proteins. The first of them is based on exploring the saddle points on selected trajectories emerging from the native state. In the second approach, the basin size can be determined by monitoring random distortions in the shape of the protein around the native state. Both techniques yield the similar results. As a byproduct, a simple method to determine the folding temperature is obtained.Comment: REVTeX, 6 pages, 5 EPS figure

    Force-induced unfolding of a homopolymer on fractal lattice: exact results vs. mean field predictions

    Full text link
    We study the force-induced unfolding of a homopolymer on the three dimensional Sierpinski gasket. The polymer is subject to a contact energy between nearest neighbour sites not consecutive along the chain and to a stretching force. The hierarchical nature of the lattice we consider allows for an exact treatment which yields the phase diagram and the critical behaviour. We show that for this model mean field predictions are not correct, in particular in the exact phase diagram there is {\em not} a low temperature reentrance and we find that the force induced unfolding transition below the theta temperature is second order.Comment: 15 pages, 5 eps figure

    Rate Determining Factors in Protein Model Structures

    Full text link
    Previous research has shown a strong correlation of protein folding rates to the native state geometry, yet a complete explanation for this dependence is still lacking. Here we study the rate-geometry relationship with a simple statistical physics model, and focus on two classes of model geometries, representing ideal parallel and antiparallel structures. We find that the logarithm of the rate shows an almost perfect linear correlation with the "absolute contact order", but the slope depends on the particular class considered. We discuss these findings in the light of experimental results.Comment: 4 pages, 2 figure

    History, trauma and remembering in Kivu Ruhorahoza’s Grey Matter (2011)

    Get PDF
    © 2016 The Author(s). In 1994, the genocide in Rwanda claimed at least 800,000 lives in just 100 days. More than twenty years on, the memory and trauma of the events still permeate the Rwandan society. This article explores how some of these different manifestations of trauma (individual and collective, actual and inherited, real and imagined, that of survivors and perpetrators), and especially their relationship to the genocide as a historical event, shape the internationally recognised Rwandan feature film, Kivu Ruhorahoza’s Grey Matter (2011). Drawing on the scholarship on trauma, the article examines Grey Matter’s uniqueness within feature films on the topic and its ambition to tackle the impossibility of memory and objectivity vis-à-vis varied experiences of the genocide. It traces the connection between trauma and Grey Matter’s structure, which refuses to offer events a firm chronological placement, both within and beyond the narrative

    Boundary conditions at a fluid - solid interface

    Full text link
    We study the boundary conditions at a fluid-solid interface using molecular dynamics simulations covering a broad range of fluid-solid interactions and fluid densities, and both simple and chain-molecule fluids. The slip length is shown to be independent of the type of flow, but rather is related to the fluid organization near the solid, as governed by the fluid-solid molecular interactions.Comment: REVtex, to appear in Physical Review Letter
    • …
    corecore