1,082 research outputs found
Tuning the polarization states of optical spots at the nanoscale on the poincar´e sphere using a plasmonic nanoantenna
It is shown that the polarization states of optical spots at the nanoscale can be manipulated to various points on the Poincar´e sphere using a plasmonic nanoantenna. Linearly, circularly, and elliptically polarized near-field optical spots at the nanoscale are achieved with various polarization states on the Poincar´e sphere using a plasmonic nanoantenna. A novel plasmonic nanoantenna is illuminated with diffraction-limited linearly polarized light. It is demonstrated
that the plasmonic resonances of perpendicular and longitudinal components of the nanoantenna and the angle of incident polarization can be tuned to obtain optical spots beyond the diffraction limit with a desired polarization and handedness
MTOR modulates intercellular signals for enlargement and infiltration in glioblastoma multiforme
Recently, exosomal release has been related to the acquisition of a malignant phenotype in glioblastoma cancer stem cells (GSCs). Remarkably, intriguing reports demonstrate that GSC-derived extracellular vesicles (EVs) contribute to glioblastoma multiforme (GBM) tumorigenesis via multiple pathways by regulating tumor growth, infiltration, and immune invasion. In fact, GSCs release tumor-promoting macrovesicles that can disseminate as paracrine factors to induce phenotypic alterations in glioma-associated parenchymal cells. In this way, GBM can actively recruit different stromal cells, which, in turn, may participate in tumor microenvironment (TME) remodeling and, thus, alter tumor progression. Vice versa, parenchymal cells can transfer their protein and genetic contents to GSCs by EVs; thus, promoting GSCs tumorigenicity. Moreover, GBM was shown to hijack EV-mediated cell-to-cell communication for self-maintenance. The present review examines the role of the mammalian Target of Rapamycin (mTOR) pathway in altering EVs/exosome-based cell-to-cell communication, thus modulating GBM infiltration and volume growth. In fact, exosomes have been implicated in GSC niche maintenance trough the modulation of GSCs stem cell-like properties, thus, affecting GBM infiltration and relapse. The present manuscript will focus on how EVs, and mostly exosomes, may act on GSCs and neighbor non tumorigenic stromal cells to modify their expression and translational profile, while making the TME surrounding the GSC niche more favorable for GBM growth and infiltration. Novel insights into the mTOR-dependent mechanisms regulating EV-mediated intercellular communication within GBM TME hold promising directions for future therapeutic applications
Germanium Plasmonic Nanoantennas for Third-Harmonic Generation in the Mid Infrared
We explore the nonlinear optical properties of plasmonic semiconductor antennas resonant in the mid infrared. The nanostructures are fabricated on silicon substrates from heavily doped germanium films with a plasma frequency of 30 THz, equivalent to a wavelength of 10 μm. Illumination with ultrashort pulses at 10.8 μm produces coherent emission at 3.6 μm via third-harmonic generation
Optical activation of germanium plasmonic antennas in the mid-infrared
Impulsive interband excitation with femtosecond near-infrared pulses establishes a plasma response in intrinsic germanium structures fabricated on a silicon substrate. This direct approach activates the plasmonic resonance of the Ge structures and enables their use as optical antennas up to the mid-infrared spectral range. The optical switching lasts for hundreds of picoseconds until charge recombination redshifts the plasma frequency. The full behavior of the structures is modeled by the electrodynamic response established by an electron-hole plasma in a regular array of antennas
Promiscuous Roles of Autophagy and Proteasome in Neurodegenerative Proteinopathies.
Alterations in autophagy and the ubiquitin proteasome system (UPS) are commonly implicated in protein aggregation and toxicity which manifest in a number of neurological disorders. In fact, both UPS and autophagy alterations are bound to the aggregation, spreading and toxicity of the so-called prionoid proteins, including alpha synuclein (α-syn), amyloid-beta (Aβ), tau, huntingtin, superoxide dismutase-1 (SOD-1), TAR-DNA-binding protein of 43 kDa (TDP-43) and fused in sarcoma (FUS). Recent biochemical and morphological studies add to this scenario, focusing on the coordinated, either synergistic or compensatory, interplay that occurs between autophagy and the UPS. In fact, a number of biochemical pathways such as mammalian target of rapamycin (mTOR), transcription factor EB (TFEB), Bcl2-associated athanogene 1/3 (BAG3/1) and glycogen synthase kinase beta (GSk3β), which are widely explored as potential targets in neurodegenerative proteinopathies, operate at the crossroad between autophagy and UPS. These biochemical steps are key in orchestrating the specificity and magnitude of the two degradation systems for effective protein homeostasis, while intermingling with intracellular secretory/trafficking and inflammatory pathways. The findings discussed in the present manuscript are supposed to add novel viewpoints which may further enrich our insight on the complex interactions occurring between cell-clearing systems, protein misfolding and propagation. Discovering novel mechanisms enabling a cross-talk between the UPS and autophagy is expected to provide novel potential molecular targets in proteinopathies
Bulk Cr tips for scanning tunneling microscopy and spin-polarized scanning tunneling microscopy
A simple, reliable method for preparation of bulk Cr tips for Scanning
Tunneling Microscopy (STM) is proposed and its potentialities in performing
high-quality and high-resolution STM and Spin Polarized-STM (SP-STM) are
investigated. Cr tips show atomic resolution on ordered surfaces. Contrary to
what happens with conventional W tips, rest atoms of the Si(111)-7x7
reconstruction can be routinely observed, probably due to a different
electronic structure of the tip apex. SP-STM measurements of the Cr(001)
surface showing magnetic contrast are reported. Our results reveal that the
peculiar properties of these tips can be suited in a number of STM experimental
situations
Exchange-induced frustration in Fe/NiO multilayers
Using spin-polarized low-energy electron microscopy to study magnetization in
epitaxial layered systems, we found that the area vs perimeter relationship of
magnetic domains in the top Fe layers of Fe/NiO/Fe(100) structures follows a
power-law distribution, with very small magnetic domain cutoff radius (about 40
nm) and domain wall thickness. This unusual magnetic microstructure can be
understood as resulting from the competition between antiferromagnetic and
ferromagnetic exchange interactions at the Fe/NiO interfaces, rather than from
mechanisms involving the anisotropy and dipolar forces that govern length
scales in conventional magnetic domain structures. Statistical analysis of our
measurements validates a micromagnetic model that accounts for this interfacial
exchange coupling.Comment: 15 pages, 2 figure
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