8,141 research outputs found

    Who's afraid of the big bad wolf: a prospective paradigm to test Rachman's indirect pathways in children

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    Rachman's theory [The conditioning theory of fear insition: a critical examination. Behav. Res. Ther. 15 (1977) 375–387] of fear acquisition suggests that fears and phobias can be acquired through three pathways: direct conditioning, vicarious learning and information/instruction. Although retrospective studies have provided some evidence for these pathways in the development of phobias during childhood [see King, Gullone, & Ollendick, Etiology of childhood phobias: current status of Rachman's three pathway's theory. Behav. Res. Ther. 36 (1998) 297–309 for a review], these studies have relied on long-term past memories of adult phobics or their parents. The current study was aimed towards developing a paradigm in which the plausibility of Rachman's indirect pathways could be investigated prospectively. In Experiment 1, children aged between 7 and 9 were presented with two types of information about novel stimuli (two monsters): video information and verbal information in the form of a story. Fear-related beliefs about the monsters changed significantly as a result of verbal information but not video information. Having established an operational paradigm, Experiment 2 looked at whether the source of verbal information had an effect on changes in fear-beliefs. Using the same paradigm, information about the monsters was provided by either a teacher, an adult stranger or a peer, or no information was given. Again, verbal information significantly changed fear-beliefs, but only when the information came from an adult. The role of information in the acquisition of fear and maintenance of avoidant behaviour is discussed with reference to modern conditioning theories of fear acquisition

    Communication of genetic information within families: the case for familial comity

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    Advances in genetic technologies raise a multitude of ethical issues, some of which give rise to novel dilemmas for medical practice. One of the most controversial problems arising in clinical genetics is that of confidentiality and who may disclose genetic health information. This paper considers the question of when it is appropriate for health professionals to disclose clinically significant genetic information without patient consent. Existing ethical principles offer little guidance in relation to this issue. We build on suggestions that genetic information may be viewed as collective or shared information, and we introduce the concept of ‘familial comity’ as a fresh way to consider the issues. Keywords: Genetics, Ethics, clinical, Confidentiality, Family, Genetic privacyThis article was written by Dr Ainsley Newson during the time of her employment with the University of Bristol, UK (2006-2012). Self-archived in the Sydney eScholarship Repository with permission of Bristol University, Sept 2014

    Communication of genetic information within families: the case for familial comity

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    Advances in genetic technologies raise a multitude of ethical issues, some of which give rise to novel dilemmas for medical practice. One of the most controversial problems arising in clinical genetics is that of confidentiality and who may disclose genetic health information. This paper considers the question of when it is appropriate for health professionals to disclose clinically significant genetic information without patient consent. Existing ethical principles offer little guidance in relation to this issue. We build on suggestions that genetic information may be viewed as collective or shared information, and we introduce the concept of ‘familial comity’ as a fresh way to consider the issues. Keywords: Genetics, Ethics, clinical, Confidentiality, Family, Genetic privacyThis article was written by Dr Ainsley Newson during the time of her employment with the University of Bristol, UK (2006-2012). Self-archived in the Sydney eScholarship Repository with permission of Bristol University, Sept 2014

    Systematic review of antimicrobial drug prescribing in hospitals.

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    Prudent antibiotic prescribing to hospital inpatients has the potential to reduce the incidences of antimicrobial resistance and healthcare-associated infection. We reviewed the literature from January 1980 to November 2003 to identify rigorous evaluations of interventions to improve hospital antibiotic prescribing. We identified 66 studies with interpretable data of which 16 reported 20 microbiological outcomes: Gram negative resistant bacteria (GNRB), 10 studies; Clostridium difficile associated diarrhoea (CDAD), 5 studies; vancomycin resistant enterococci (VRE), 3 studies and methicillin resistant Staphylococcus aureus (MRSA), 2 studies. Four studies provide good evidence that the intervention changed microbial outcomes with low risk of alternative explanations, eight studies provide less convincing evidence and four studies were negative. The strongest and most consistent evidence was for CDAD but we were able to analyse only the immediate impact of interventions because of nonstandardised durations of follow up. The ability to compare results of studies could be substantially improved by standardising methodology and reporting

    A Proof of Tarski’s Fixed Point Theorem by Application of Galois Connections

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    Two examples of Galois connections and their dual forms are considered. One of them is applied to formulate a criterion when a given subset of a complete lattice forms a complete lattice. The second, closely related to the first, is used to prove in a short way the Knaster-Tarski’s fixed point theore

    Immunity as the predominant factor determining metastasis by murine lymphomas.

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    The metastatic behaviour of the L5178E (non-M) lymphoma and a highly metastatic subline L51787ES (M) were studied in syngeneic DBA2 mice. The non-M tumour rarely metastasizes in intact syngeneic mice, but produces extensive and rapidly lethal metastases when implanted into irradiated recipients. The metastatic behaviour of the M subline is unaffected by irradiation of the host. By conventional transplantation criteria, the non-M tumour is more immunogenic than the M subline. Both tumours, however, produce similar responses in a lymphnode weight-gain assay. Host-cell infiltration of the tumours growing s.c. is much greater in the non-M than the M, the infiltrating cells being Fc-receptor-positive and maturing into macrophages after 2 days in vitro. Although spontaneous in vitro motility of the M cells is much greater than that of the non-M, the metastatic behaviour of the tumours is clearly determined by host immunological responses

    The Midspan studies

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    Tsunami Evacuation Planning as a tool for Tsunami Risk Reduction: A case study in Palu Bay, Central Sulawesi

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    Situated in one of the most complicated tectonic zones of the world, Palu is classified as one of the most susceptible places to earthquake and tsunami in Indonesia. This study aim to develop near-field tsunami evacuation simulation, as the primary strategy to reduce casualties in disaster risk reduction, based on daytime and night-time population scenarios in a tsunami-prone area in Palu Bay, Central Sulawesi. Least Cost Distance, a geospatial evacuation analysis approach in ArcGIS, is applied involving three main variables, namely population exposure, the arrival time of tsunami and walking speed of evacuees. These variables were analysed to calculate distribution of populations in daytime and night-time scenario; to identify and calculate the capacity of potential existing evacuation shelter buildings (ESB); and to analyse suitable locations, and to calculate the number and capacity of additional ESBs based on the most effective evacuation route. This study found that of the population in the study area, about 62.60 % cannot be sheltered in the seven existing ESB in the daytime as well as 63.98% of total population in the night-time scenario. Meanwhile,only 60.13% and 61.83% of the population in the service area of existing ESBs, can be evacuated in daytime and night-time scenarios, respectively. Therefore, eleven and twelve additional ESBs are proposed to be established for daytime and night-time scenarios, respectively, to accommodate people who currently cannot be sheltered
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