2,530 research outputs found
Ontological support for managing non-functional requirements in pervasive healthcare
We designed and implemented an ontological solution which makes provisions for choosing adequate devices/sensors for remote monitoring of patients who are suffering from post-stroke health complications. We argue that non-functional requirements in pervasive healthcare systems can be elicited and managed through semantics stored in ontological models and reasoning created upon them. Our contribution is twofold: we enrich the elicitation process and specification of non-functional requirements within the requirements engineering discipline and we address the pervasiveness of healthcare software systems through the way of choosing devices embedded in them and users expectations in terms of having access to pervasive services personalized to their needs
Why Do Compact Active Galactic Nuclei at High Redshift Scintillate Less?
The fraction of compact active galactic nuclei (AGNs) that exhibit
interstellar scintillation (ISS) at radio wavelengths, as well as their
scintillation amplitudes, have been found to decrease significantly for sources
at redshifts z > 2. This can be attributed to an increase in the angular sizes
of the \muas-scale cores or a decrease in the flux densities of the compact
\muas cores relative to that of the mas-scale components with increasing
redshift, possibly arising from (1) the space-time curvature of an expanding
Universe, (2) AGN evolution, (3) source selection biases, (4) scatter
broadening in the ionized intergalactic medium (IGM) and intervening galaxies,
or (5) gravitational lensing. We examine the frequency scaling of this redshift
dependence of ISS to determine its origin, using data from a dual-frequency
survey of ISS of 128 sources at 0 < z < 4. We present a novel method of
analysis which accounts for selection effects in the source sample. We
determine that the redshift dependence of ISS is partially linked to the
steepening of source spectral indices ({\alpha}^8.4_4.9) with redshift, caused
either by selection biases or AGN evolution, coupled with weaker ISS in the
{\alpha}^8.4_4.9 < -0.4 sources. Selecting only the -0.4 < {\alpha}^8.4_4.9 <
0.4 sources, we find that the redshift dependence of ISS is still significant,
but is not significantly steeper than the expected (1+z)^0.5 scaling of source
angular sizes due to cosmological expansion for a brightness temperature and
flux-limited sample of sources. We find no significant evidence for scatter
broadening in the IGM, ruling it out as the main cause of the redshift
dependence of ISS. We obtain an upper limit to IGM scatter broadening of <
110\muas at 4.9 GHz with 99% confidence for all lines of sight, and as low as <
8\muas for sight-lines to the most compact, \sim 10\muas sources.Comment: 38 pages, 13 figures, accepted for publication in The Astrophysical
Journa
Anti-tumor effects of retinoids combined with trastuzumab or tamoxifen in breast cancer cells: induction of apoptosis by retinoid/trastuzumab combinations
INTRODUCTION: HER2 and estrogen receptor (ER) are important in breast cancer and are therapeutic targets of trastuzumab (Herceptin) and tamoxifen, respectively. Retinoids inhibit breast cancer growth, and modulate signaling by HER2 and ER. We hypothesized that treatment with retinoids and simultaneous targeting of HER2 and/or ER may have enhanced anti-tumor effects. METHODS: The effects of retinoids combined with trastuzumab or tamoxifen were examined in two human breast cancer cell lines in culture, BT474 and SKBR3. Assays of proliferation, apoptosis, differentiation, cell cycle distribution, and receptor signaling were performed. RESULTS: In HER2-overexpressing/ER-positive BT474 cells, combining all-trans retinoic acid (atRA) with tamoxifen or trastuzumab synergistically inhibited cell growth, and altered cell differentiation and cell cycle. Only atRA/trastuzumab-containing combinations induced apoptosis. BT474 and HER2-overexpressing/ER-negative SKBR3 cells were treated with a panel of retinoids (atRA, 9-cis-retinoic acid, 13-cis-retinoic acid, or N-(4-hydroxyphenyl) retinamide (fenretinide) (4-HPR)) combined with trastuzumab. In BT474 cells, none of the single agents except 4-HPR induced apoptosis, but again combinations of each retinoid with trastuzumab did induce apoptosis. In contrast, the single retinoid agents did cause apoptosis in SKBR3 cells; this was only modestly enhanced by addition of trastuzumab. The retinoid drug combinations altered signaling by HER2 and ER. Retinoids were inactive in trastuzumab-resistant BT474 cells. CONCLUSIONS: Combining retinoids with trastuzumab maximally inhibits cell growth and induces apoptosis in trastuzumab-sensitive cells. Treatment with such combinations may have benefit for breast cancer patients
Analytical Estimate of the Critical Velocity for Vortex Pair Creation in Trapped Bose Condensates
We use a modified Thomas-Fermi approximation to estimate analytically the
critical velocity for the formation of vortices in harmonically trapped BEC. We
compare this analytical estimate to numerical calculations and to recent
experiments on trapped alkali condensates.Comment: 12 page
Atypical mycotic lesion in the guttural pouch of a Thoroughbred race horse
A six-year-old Thoroughbred race horse was presented with left unilateral mucopurulent nasal discharge. Endoscopic examination revealed atypical mycotic lesion within the guttural pouch in which the fungal mass was not located on any neurovascular structures. This case was successfully treated by the combination of manual debulking of fungal diphtheritic plaques and medical treatment that included daily local irrigation and systemic medication. There were no complications and the horse returned to race three weeks later
The effects of abusive supervision, emotional exhaustion and organizational commitment on cyberloafing: a moderated-mediation examination
Purpose – Cyberloafing (employees’ non-work-related online activities at work) has become a common workplace problem for many organizations. Research investigating the underlying mechanisms and boundary conditions under which abusive supervision influences cyberloafing remains largely underdeveloped. Drawing from social exchange theory and conservation of resources theory, we developed a moderated-mediation model in which emotional exhaustion was theorized as a unique mechanism underlining why employees are more
likely to engage in cyberloafing under the supervision of abusive leaders. In addition, we proposed that organizational commitment to be a relevant boundary condition to influence such a relationship.
Design/methodology/approach – We collected 255 data from employees working in public listed companies in Malaysia and used partial least squares structural equation modeling (PLS-SEM) to analyze the data.
Findings – The results showed that the influence of abusive supervision on cyberloafing through emotional
exhaustion is only significant when organizational commitment is low.
Originality/value – This study constructed a moderated-mediation model by introducing the potential mediating effect of emotional exhaustion and the moderating effect of organizational commitment to reveal the mechanism through which abusive supervision related to cyberloafing
Dual-Frequency Observations of 140 Compact, Flat-Spectrum Active Galactic Nuclei for Scintillation-Induced Variability
The 4.9 GHz Micro-Arcsecond Scintillation-Induced Variability (MASIV) Survey
detected a drop in Interstellar Scintillation (ISS) for sources at redshifts z
> 2, indicating an apparent increase in angular diameter or a decrease in flux
density of the most compact components of these sources, relative to their
extended emission. This can result from intrinsic source size effects or
scatter broadening in the Intergalactic Medium (IGM), in excess of the expected
(1+z)^0.5 angular diameter scaling of brightness temperature limited sources
due to cosmological expansion. We report here 4.9 GHz and 8.4 GHz observations
and data analysis for a sample of 140 compact, flat-spectrum sources which may
allow us to determine the origin of this angular diameter-redshift relation by
exploiting their different wavelength dependences. In addition to using ISS as
a cosmological probe, the observations provide additional insight into source
morphologies and the characteristics of ISS. As in the MASIV Survey, the
variability of the sources is found to be significantly correlated with
line-of-sight H-alpha intensities, confirming its link with ISS. For 25
sources, time delays of about 0.15 to 3 days are observed between the
scintillation patterns at both frequencies, interpreted as being caused by a
shift in core positions when probed at different optical depths. Significant
correlation is found between ISS amplitudes and source spectral index; in
particular, a large drop in ISS amplitudes is observed at spectral indices of <
-0.4 confirming that steep spectrum sources scintillate less. We detect a
weakened redshift dependence of ISS at 8.4 GHz over that at 4.9 GHz, with the
mean variance at 4-day timescales reduced by a factor of 1.8 in the z > 2
sources relative to the z < 2 sources, as opposed to the factor of 3 decrease
observed at 4.9 GHz. This suggests scatter broadening in the IGM.Comment: 30 pages, 14 figures, accepted for publication in the Astronomical
Journa
Intra-day variability observations of S5 0716+714 over 4.5 years at 4.8 GHz
We aim to search for evidence of annual modulation in the time scales of the
BL Lac object S5 0716+714. The intra-day variability (IDV) observations were
carried out monthly from 2005 to 2009, with the Urumqi 25m radio telescope at
4.8 GHz. The source has shown prominent IDV as well as long-term flux
variations. The IDV time scale does show evidence in favor of an annual
modulation, suggesting that the IDV of 0716+714 is dominated by interstellar
scintillation. The source underwent a strong outburst phase between mid-2008
and mid-2009; a second intense flare was observed in late 2009, but no
correlation between the total flux density and the IDV time scale is found,
implying that the flaring state of the source does not have serious
implications for the general characteristics of its intra-day variability.
However, we find that the inner-jet position angle is changing throughout the
years, which could result in an annual modulation noise in the anisotropic ISS
model fit. There is also an indication that the lowest IDV amplitudes (rms flux
density) correspond to the slowest time scales of IDV, which would be
consistent with an ISS origin of the IDV of 0716+714.Comment: 6 pages, 7 figures, accepted for publication in A&A; corrected typos
in Table
Detection of Six Rapidly Scintillating AGNs and the Diminished Variability of J1819+3845
The extreme, intra-hour and > 10% rms flux density scintillation observed in
AGNs such as PKS 0405-385, J1819+3845 and PKS 1257-326 at cm wavelengths has
been attributed to scattering in highly turbulent, nearby regions in the
interstellar medium. Such behavior has been found to be rare. We searched for
rapid scintillators among 128 flat spectrum AGNs and analyzed their properties
to determine the origin of such rapid and large amplitude radio scintillation.
The sources were observed at the VLA at 4.9 and 8.4 GHz simultaneously at two
hour intervals over 11 days. We detected six rapid scintillators with
characteristic time-scales of
10%. We found strong lines of evidence linking rapid scintillation to the
presence of nearby scattering regions, estimated to be < 12 pc away for ~ 200
muas sources and < 250 pc away for ~ 10 muas sources. We attribute the scarcity
of rapid and large amplitude scintillators to the requirement of additional
constraints, including large source compact fractions. J1819+3845 was found to
display ~ 2% rms variations at ~ 6 hour time-scales superposed on longer > 11
day variations, suggesting that the highly turbulent cloud responsible for its
extreme scintillation has moved away, with its scintillation now caused by a
more distant screen ~ 50 to 150 pc away.Comment: 5 pages, 3 figures, accepted for publication in Astronomy and
Astrophysic
The Commensal Real-time ASKAP Fast Transients (CRAFT) survey
We are developing a purely commensal survey experiment for fast (<5s)
transient radio sources. Short-timescale transients are associated with the
most energetic and brightest single events in the Universe. Our objective is to
cover the enormous volume of transients parameter space made available by
ASKAP, with an unprecedented combination of sensitivity and field of view. Fast
timescale transients open new vistas on the physics of high brightness
temperature emission, extreme states of matter and the physics of strong
gravitational fields. In addition, the detection of extragalactic objects
affords us an entirely new and extremely sensitive probe on the huge reservoir
of baryons present in the IGM. We outline here our approach to the considerable
challenge involved in detecting fast transients, particularly the development
of hardware fast enough to dedisperse and search the ASKAP data stream at or
near real-time rates. Through CRAFT, ASKAP will provide the testbed of many of
the key technologies and survey modes proposed for high time resolution science
with the SKA.Comment: accepted for publication in PAS
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