On the feasibility of detecting quantum delocalization effects on gravitational redshift in optical clocks

We derive the predicted time dilation of delocalized atomic clocks in an optical lattice setup in the presence of a gravitational field to leading order in quantum relativistic corrections. We investigate exotic quantum states of motion whose gravitational time dilation is outside of the realm of classical general relativity, finding a regime where $^{24}\mathrm{Mg}$ optical lattice clocks currently in development would comfortably be able to detect this quantum effect (if the technical challenge of generating such states can be met). We provide a detailed experimental protocol and analyse the effects of noise on our predictions. We also show that the magnitude of our predicted quantum gravitational time dilation effect remains just out of detectable reach for the current generation of $^{87}\mathrm{Sr}$ optical lattice clocks. Our calculations agree with the predicted time dilation of classical general relativity when restricting to Gaussian states

Infrared plasmons propagate through a hyperbolic nodal metal

Metals are canonical plasmonic media at infrared and optical wavelengths, allowing one to guide and manipulate light at the nanoscale. A special form of optical waveguiding is afforded by highly anisotropic crystals revealing the opposite signs of the dielectric functions along orthogonal directions. These media are classified as hyperbolic and include crystalline insulators, semiconductors, and artificial metamaterials. Layered anisotropic metals are also anticipated to support hyperbolic waveguiding. However, this behavior remains elusive, primarily because interband losses arrest the propagation of infrared modes. Here, we report on the observation of propagating hyperbolic waves in a prototypical layered nodal-line semimetal ZrSiSe. The observed waveguiding originates from polaritonic hybridization between near-infrared light and nodal-line plasmons. Unique nodal electronic structures simultaneously suppress interband loss and boost the plasmonic response, ultimately enabling the propagation of infrared modes through the bulk of the crystal

Targeted Deletion of Kcne2 Causes Gastritis Cystica Profunda and Gastric Neoplasia

Gastric cancer is the second leading cause of cancer death worldwide. Predisposing factors include achlorhydria, Helicobacter pylori infection, oxyntic atrophy and TFF2-expressing metaplasia. In parietal cells, apical potassium channels comprising the KCNQ1 α subunit and the KCNE2 β subunit provide a K+ efflux current to facilitate gastric acid secretion by the apical H+K+ATPase. Accordingly, genetic deletion of murine Kcnq1 or Kcne2 impairs gastric acid secretion. Other evidence has suggested a role for KCNE2 in human gastric cancer cell proliferation, independent of its role in gastric acidification. Here, we demonstrate that 1-year-old Kcne2−/− mice in a pathogen-free environment all exhibit a severe gastric preneoplastic phenotype comprising gastritis cystica profunda, 6-fold increased stomach mass, increased Ki67 and nuclear Cyclin D1 expression, and TFF2- and cytokeratin 7-expressing metaplasia. Some Kcne2−/−mice also exhibited pyloric polypoid adenomas extending into the duodenum, and neoplastic invasion of thin walled vessels in the sub-mucosa. Finally, analysis of human gastric cancer tissue indicated reduced parietal cell KCNE2 expression. Together with previous findings, the results suggest KCNE2 disruption as a possible risk factor for gastric neoplasia

MiR-218 Inhibits Invasion and Metastasis of Gastric Cancer by Targeting the Robo1 Receptor

MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased along with the expression of one of its host genes, Slit3 in metastatic GC. However, Robo1, one of several Slit receptors, is negatively regulated by miR-218, thus establishing a negative feedback loop. Decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis. The restoration of miR-218 suppresses Robo1 expression and inhibits tumor cell invasion and metastasis in vitro and in vivo. Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis

Get comfortable with being uncomfortable: Experiences from diagnostic radiographers a year into the COVID-19 pandemic

In Singapore, the ripple effect from the first imported case has been powerful. In the first few days there was little sign of the impact that was coming. While there was some sense of worry, everyday life went on. No one expected the impact of COVID-19 to be so dramatic that certain aspects of the population's daily life had to be permanently modified. Drastic changes were made to the country's working lifestyle, society, economy, and healthcare sector -a result of public health measures introduced by the government. Through local transmission, the pandemic rapidly reached statistical milestones. Within 2 weeks after first case was reported, Singapore's risk assessment was raised following increased local community spread [2]. The tipping point occurred when Singapore experienced increased risk of asymptomatic spread, which led to the implementation of an elevated set of safe distancing measures from April 7 to June 1 (1 month, 3 weeks and 4 days) [3,4]. The duration of the “circuit breaker”, which included partial lockdowns, had a significant impact on many. From an economic perspective, this safe distancing measure has been estimated to have reduced Singapore's annual real gross domestic product (GDP) by 2.2

Determination of critical cooling rates in metallic glass forming alloy libraries through laser spike annealing

The glass forming ability (GFA) of metallic glasses (MGs) is quantified by the critical cooling rate (R C). Despite its key role in MG research, experimental challenges have limited measured R C to a minute fraction of known glass formers. We present a combinatorial approach to directly measure R C for large compositional ranges. This is realized through the use of compositionally-graded alloy libraries, which were photo-thermally heated by scanning laser spike annealing of an absorbing layer, then melted and cooled at various rates. Coupled with X-ray diffraction mapping, GFA is determined from direct R C measurements. We exemplify this technique for the Au-Cu-Si system, where we identify Au56Cu27Si17 as the alloy with the highest GFA. In general, this method enables measurements of R C over large compositional areas, which is powerful for materials discovery and, when correlating with chemistry and other properties, for a deeper understanding of MG formation