711 research outputs found
Adnexal torsion in a patient with Müllerian agenesis undergoing ovarian stimulation: a case report
Background: As assisted reproductive technologies become increasingly available to patients, more women with Müllerian agenesis may undergo ovarian stimulation and oocyte retrieval to have genetically-related offspring. The risk of ovarian torsion is increased in patients utilizing assisted reproductive technologies compared to patients who do not undergo these treatments.
Case: A 25-year-old G0 with Mayer-Rokitansky-Kuster-Hauser syndrome presented to the emergency room two days after oocyte retrieval with an acute abdomen. During laparoscopy, she was found to have torsion of her left ovary.
Summary and Conclusion: As more young women with Müllerian agenesis present for fertility treatment, this anatomically unique patient cohort may be at an especially high risk for ovarian torsion. Physicians should recognize this risk and counsel their patients on this risk when discussing fertility options in patients with Müllerian agenesis
Optimizing a Certified Proof Checker for a Large-Scale Computer-Generated Proof
In recent work, we formalized the theory of optimal-size sorting networks
with the goal of extracting a verified checker for the large-scale
computer-generated proof that 25 comparisons are optimal when sorting 9 inputs,
which required more than a decade of CPU time and produced 27 GB of proof
witnesses. The checker uses an untrusted oracle based on these witnesses and is
able to verify the smaller case of 8 inputs within a couple of days, but it did
not scale to the full proof for 9 inputs. In this paper, we describe several
non-trivial optimizations of the algorithm in the checker, obtained by
appropriately changing the formalization and capitalizing on the symbiosis with
an adequate implementation of the oracle. We provide experimental evidence of
orders of magnitude improvements to both runtime and memory footprint for 8
inputs, and actually manage to check the full proof for 9 inputs.Comment: IMADA-preprint-c
Error analysis of free probability approximations to the density of states of disordered systems
Theoretical studies of localization, anomalous diffusion and ergodicity
breaking require solving the electronic structure of disordered systems. We use
free probability to approximate the ensemble- averaged density of states
without exact diagonalization. We present an error analysis that quantifies the
accuracy using a generalized moment expansion, allowing us to distinguish
between different approximations. We identify an approximation that is accurate
to the eighth moment across all noise strengths, and contrast this with the
perturbation theory and isotropic entanglement theory.Comment: 5 pages, 3 figures, submitted to Phys. Rev. Let
Long-range interactions from the many-pair expansion: A different avenue to dispersion in DFT
One of the several problems that plague majority of density functional theory calculations is their inability to properly account for long-range correlations giving rise to dispersion forces. The recently proposed many-pair expansion (MPE) [T. Zhu et al., Phys. Rev. B 93, 201108(R) (2016)] is a hierarchy of approximations that systematically corrects any deficiencies of an approximate functional to finally converge to the exact energy. This is achieved by decomposing the total density into a sum of two-electron densities and accounting for successive two-, four-, six-,… electron interactions. Here, we show that already low orders of MPE expansion recover the dispersion energy accurately. To this end, we employ the Pariser-Parr-Pople Hamiltonian and study the behavior of long-range interactions in trans-polyacetylene as well as stacks of ethylene and benzene molecules. We also show how convergence of the expansion is affected by electron conjugation and the choice of the density partitioning.National Science Foundation (U.S.) (Grant CHE-1464804
Initial Results From the First Field Expedition of UAPx to Study Unidentified Anomalous Phenomena
In July 2021, faculty from the UAlbany Department of Physics participated in
a week-long field expedition with the organization UAPx to collect data on UAPs
in Avalon, California, located on Catalina Island, and nearby. This paper
reviews both the hardware and software techniques which this collaboration
employed, and contains a frank discussion of the successes and failures, with a
section about how to apply lessons learned to future expeditions. Both
observable-light and infrared cameras were deployed, as well as sensors for
other (non-EM) emissions. A pixel-subtraction method was augmented with other
similarly simple methods to provide initial identification of objects in the
sky and/or the sea crossing the cameras' fields of view. The first results will
be presented based upon approximately one hour in total of triggered
visible/night-vision-mode video and over 600 hours of untriggered (far) IR
video recorded, as well as 55 hours of (background) radiation measurements.
Following multiple explanatory resolutions of several ambiguities that were
potentially anomalous at first, we focus on the primary remaining ambiguity
captured at approximately 4am Pacific Time on Friday, July 16: a dark spot in
the visible/near-IR camera possibly coincident with ionizing radiation that has
thus far resisted a prosaic explanation. We conclude with quantitative
suggestions for serious researchers in this still-nascent field of
hard-science-based UAP studies, with an ultimate goal of identifying UAPs
without confirmation bias toward either mundane or speculative conclusions.Comment: 43 pages, 16 figures, 2 tables, 18 equations, and 64 reference
Introducing a gender-sensitive approach to pre-trial assessment and probation: Evaluation of an innovation in Kenya
This paper evaluates a pioneering project to introduce a gender-sensitive approach to working with women completing probation and community service orders in Kenya. The intervention consisted of context-specific research with women throughout Kenya, leading to adaptations to existing probation tools, followed by pilot implementation of a gender-sensitive approach. The evaluation explores the relevance, effectiveness and sustainability of the intervention and presents opinions of implementing probation officers and sector experts. Findings suggest that the project genuinely broke new ground in terms of research on gender-sensitivity and quality of pre-trial reporting for women. Close adherence to the UN Bangkok Rules means the model and lessons are applicable both domestically and globally
Spin Resolution of the Electron-Gas Correlation Energy: Positive same-spin contribution
The negative correlation energy per particle of a uniform electron gas of
density parameter and spin polarization is well known, but its
spin resolution into up-down, up-up, and down-down contributions is not.
Widely-used estimates are incorrect, and hamper the development of reliable
density functionals and pair distribution functions. For the spin resolution,
we present interpolations between high- and low-density limits that agree with
available Quantum Monte Carlo data. In the low-density limit for ,
we find that the same-spin correlation energy is unexpectedly positive, and we
explain why. We also estimate the up and down contributions to the kinetic
energy of correlation.Comment: new version, to appear in PRB Rapid Communicatio
NMR structure of an acyl-carrier protein from Borrelia burgdorferi
The high-resolution NMR structure of the acyl-carrier protein from the pathogen B. burgdorferi determined to a r.m.s. deviation of 0.4 Å over the protein backbone is reported. The NMR structure was determined using multidimensional NMR spectroscopy and consists of four α-helices and two 310-helices. Structural comparison reveals that this protein is highly similar to the acyl-carrier protein from A. aeolicus
Observations of the Antarctic polar front during FDRAKE 76 : a cruise report
Figures 37 and 38 have been reduced from their original size for the purpose of scanning.During March/April 1976 the small-scale structure of the Antarctic Polar Front was observed in the Drake Passage. The
observations were part of the International Southern Ocean Studies (ISOS) program called FDRAke 76. The purpose of the
program was to obtain densely sampled measurements of temperature,
salinity, dissolved oxygen, and chemical nutrients in
the Polar Front Zone (PFZ) and pilot measurements of horizontal
and vertical velocities in order to explain the above scalar
variability. The PFZ is a region where Antarctic and sub-Antarctic waters intermingle and presumably mix to affect the
properties of Antarctic Intermediate Water. A report on the
third leg of Cruise 107 of the R. V. THOMPSON is presented as
well as a description of the measurements and a preliminary
report of the data. A feature of interest is the pinching off
of a northward meander of the circumpolar current system into
a cyclonic ring of Antarctic Waters.Prepared for the National Science Foundation, Office
for the International Decade of Ocean Exploration,
under Grant OCE75-14056 and the International Southern
Ocean Studies (ISOS) Program
TDR Targets: a chemogenomics resource for neglected diseases
The TDR Targets Database (http://tdrtargets.org) has been designed and developed as an online resource to facilitate the rapid identification and prioritization of molecular targets for drug development, focusing on pathogens responsible for neglected human diseases. The database integrates pathogen specific genomic information with functional data (e.g. expression, phylogeny, essentiality) for genes collected from various sources, including literature curation. This information can be browsed and queried using an extensive web interface with functionalities for combining, saving, exporting and sharing the query results. Target genes can be ranked and prioritized using numerical weights assigned to the criteria used for querying. In this report we describe recent updates to the TDR Targets database, including the addition of new genomes (specifically helminths), and integration of chemical structure, property and bioactivity information for biological ligands, drugs and inhibitors and cheminformatic tools for querying and visualizing these chemical data. These changes greatly facilitate exploration of linkages (both known and predicted) between genes and small molecules, yielding insight into whether particular proteins may be druggable, effectively allowing the navigation of chemical space in a genomics context
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