Editorial : Autophagy : from big data to physiological significance

Autophagy is a fundamental catabolic process where cytoplasmic components are sequestered into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their content is degraded. Our knowledge about autophagy sharply increased during the last decade. This significant progress helped us to understand better the molecular mechanisms of autophagy and to elucidate its role in health and disease. This special issue contains a collection of three original research papers and 12 review articles covering a broad range of topics highlighting how big data and screening approaches can help toward uncovering the molecular mechanisms of autophagy

The role of smart sensor networks for voltage monitoring in smart grids

The large-scale deployment of the Smart Grid paradigm will support the evolution of conventional electrical power systems toward active, flexible and self-healing web energy networks composed of distributed and cooperative energy resources. In a Smart Grid platform, distributed voltage monitoring is one of the main issues to address. In this field, the application of traditional hierarchical monitoring paradigms has some disadvantages that could hinder their application in Smart Grids where the constant growth of grid complexity and the need for massive pervasion of Distribution Generation Systems (DGS) require more scalable, more flexible control and regulation paradigms. To try to overcome these challenges, this paper proposes the concept of a decentralized non-hierarchal voltage monitoring architecture based on intelligent and cooperative smart entities. These devices employ traditional sensors to acquire local bus variables and mutually coupled oscillators to assess the main variables describing the global grid state

The Asolant/Rubin-5 Technology Demonstration Mission - System Description and First Flight Results

This paper addresses the Asolant/Rubin-5 flight experiment conducted onboard the upper stage of a Cosmos rocket in late 2005. The main objective of the project was to flight-qualify a newly developed combined solar cell/antenna device, the so-called Advanced SOLar ANTenna (ASOLANT) technology. In order to assess both, the reception as well as emission of R/F signals, two different devices were involved in the mission. One was linked to a space-borne Phoenix-S GPS receiver to examine the receiving performance. A second device was designed to send out S-Band beacon signals generated by the SAFIR-S amateur radio transmitter to evaluate the radiation characteristics. Moreover, both ASOLANT devices supplied the electrical power for the onboard systems. Telecommand and telemetry functionalities were provided by an ORBCOMM communicator making use of the ORBCOMM satellite network to relay data between space and ground. This unit, furthermore, served as onboard computer. The experiment was launched along with eight multinational payload satellites. It was designed to remain attached to the rockets upper stage after burnout. Due to a separation failure of one of the copassengers, the primary mission objectives could not be fully met. Nevertheless, a sufficient number of data was retrieved to confirm the good overall performance of the ASOLANT devices. Roughly ten month after the launch, still most system components are operational and experiment data are transmitted to ground. Following a description of the main flight system components and the overall ystem architecture, the paper summarizes the hitherto obtained experiment results

Particle-wave duality: a dichotomy between symmetry and asymmetry

Symmetry plays a central role in many areas of modern physics. Here we show that it also underpins the dual particle and wave nature of quantum systems. We begin by noting that a classical point particle breaks translational symmetry whereas a wave with uniform amplitude does not. This provides a basis for associating particle nature with asymmetry and wave nature with symmetry. We derive expressions for the maximum amount of classical information we can have about the symmetry and asymmetry of a quantum system with respect to an arbitrary group. We find that the sum of the information about the symmetry (wave nature) and the asymmetry (particle nature) is bounded by log(D) where D is the dimension of the Hilbert space. The combination of multiple systems is shown to exhibit greater symmetry and thus more wavelike character. In particular, a class of entangled systems is shown to be capable of exhibiting wave-like symmetry as a whole while exhibiting particle-like asymmetry internally. We also show that superdense coding can be viewed as being essentially an interference phenomenon involving wave-like symmetry with respect to the group of Pauli operators.Comment: 20 pages, 3 figure

Knowledge, attitudes, and behavior concerning dental trauma among parents of children attending primary school

BACKGROUND: Traumatic dental injuries occur frequently in children and adolescents. The purpose of the present study is to examine the levels of knowledge and behaviors regarding dental trauma among parents of children attending primary schools in the Apulia region of Italy. METHODS: The study was carried out using an anonymous questionnaire with closed answers distributed to 2,775 parents who were enrolled based on the entire regional school population. Analyses were conducted using the PROC CORRESP (procedure to perform multiple correspondence analysis) and PROC FASTCLUS (procedure to perform cluster analysis). Statistical significance was set at p-value <0.05. RESULTS: A total 15.5% of the sample reported that their children had experienced dental trauma. Overall, 53.8% of respondents stated that they knew what to do in cases of dental injury. Regarding the time limit within which it is possible to usefully intervene for dental trauma, 56.8% of respondents indicated "within 30 minutes". Of the total sample, 56.5% knew how to preserve a displaced tooth. A total 62.9% of parents felt it was appropriate for their children to use dental guards during sports activities. The multivariate analysis showed that wrong knowledge are distributed among all kinds of subject. Parents with previous experience of dental trauma referred right behaviours, instead weak knowledge and wrong behaviours are associated with parents that easily worried for dental events. CONCLUSIONS: This study showed that most parents reported no experience of dental trauma in their children, and half of them did not know what to do in case of traumatic dental injury and they would intervene within 30 minutes, suggesting that dental trauma may trigger panic. However, they did not have the information needed to best assist the affected child. Motivating parents to assume a preventive approach towards dental trauma may produce positive changes that would result an increase of long-term health benefits among both parents and children

Industrial Problems Encountered in the Eddy Current Inspection of Steel

It is anticipated, that through exposing some of the problems encountered in industrial applications of eddy current technology, technical assistance may be generated through the theoretical community. The specific problem examined involves the development, storage\u27and utilization of calibration masters. Although the use of probes versus coils greatly reduces the number of calibration masters in that probes are not sensitive to overall geometry and mass variations, the eddy current response is influenced by near probe geometry variations. At present, an empirically derived algorithm is relied upon to characterize this phenomenon although it is hoped that an appropriate theoretical model will be developed. In addition to geometry, the non-linear permeability present in ferromagnetics, and the microstructural and compositional variations greatly increase the complexity of constructing such a model