The Challenges of the "Software Support for Industrial Controls" Contract

ST division is currently specifying a 'Software Support for Industrial Controls' contract. The application of this contract and its success will require several changes in our habits for specifying, designing, and maintaining control systems. This paper summarizes some key concepts which should be respected in order to obtain maximum benefits from the future contract and to optimize the software activities in the division. The contract concerns the maintenance and development of the monitoring and control systems used for supervising CERN's technical infrastructure (electrical distribution, cooling water, air conditioning, safety, and access control). The systems concerned consist of computer and communication hardware and software, tailored to provide specific functionalities for the remote operation, command, and monitoring of equipment. All these systems use commercially available software and hardware such as SCADA, PLCs and associated drivers, controllers, fieldbuses, and networks. It is intended to contract out these activities on a results-oriented basis

Software Support for Industrial Controls Contract

The contract covers the development and the operation and maintenance (O&M) of the monitoring and control systems used for supervising CERN's technical infrastructure. The contract involves those responsible for equipment in any current or future technical installation. We are outsourcing a complex activity which will require efforts on both preparing the specifications for new projects and setting clear definitions of tasks and procedures for O&M. It is a result-oriented contract in which performance will be continually evaluated by different methods and tools: project management plan and project follow-up, and CAMMS (Computerised Assets and Maintenance Management system). To be used effectively, this approach requires complete traceability of activities and documentation of the systems. Based on the analysis of the results measured and the shared (CERN and contractor) experience, the O&M activities will be reviewed and reorganised and operational procedures will be changed according to needs. A key issue of this contract is the challenge of establishing a good partnership with the contractor in order to reach the goals

Anti-inflammatory, pro-proliferative and antimicrobial potential of the compounds isolated from Daemonorops draco (Willd.) Blume

Ethno-pharmacological relevance: Daemonorops draco (D. draco) commonly known as “Dragon's blood” is one of the most used plants by Momok, Anak Dalam and Talang Mamak tribes from Indonesia as a remedy for wound healing. Aim of the study: This study aimed to identify the extract, fractions and compounds responsible for the anti-inflammatory and pro-proliferative activities of the D. draco resin. Additionally, the antimicrobial activity against two bacteria and one yeast species was analysed. Materials and methods: Bio-guided isolation of compounds with anti-inflammatory, pro-proliferative and antimicrobial activities from the D. draco resin was carried out by measuring: the inhibition of NF-κB and activation of Nrf2 in THP-1, HaCaT, NIH-3T3 cells; cell proliferation in NIH-3T3 and HaCaT cells; and the antimicrobial effect on E. coli, S. aureus and C. albicans. Results: Guided isolation by bioassay gave rise to the isolation and characterisation by nuclear magnetic resonance and mass spectrometry of three compounds: 1 (Bexarotene), 2 (Taspine) and 3 (2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone). All compounds showed NF-κB inhibitory activity with IC50 values of 0.10–0.13, 0.22–0.24 and 3.75–4.78 μM, respectively, while the positive control, Celastrol, had an IC50 of 7.96 μM. Likewise, all compounds showed an activating effect of Nrf2 with EC50 values of 5.34–5.43, 163.20–169.20 and 300.82–315.56 nM, respectively, while the positive control, CDDO-Me, had an EC50 of 0.11 nM. In addition, concerning the pro-proliferative activity, compound 1 (IC50 = 8.62–8.71 nM) showed a capacity of 100%, compound 2 (IC50 = 166–171 nM) showed a capacity of 75%, and compound 3 (IC50 = 469–486 nM) showed a capacity of 65%, while FSB 10% (positive control) had a pro-proliferative activity of 100% in the NIH3T3 cell lines (fibroblasts) and HaCaT (keratinocytes). Finally, all the compounds showed antimicrobial activity with MIC values of 0.12–0.16, 0.31–0.39 and 3.96–3.99 μM, respectively, in S. aureus, E. coli and C. albicans strains, while the positive control, Ofloxacin, had a MIC of 27.65 μM. Conclusion: This study managed to isolate, for the first time, three compounds (Bexarotene, Taspine and 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone) from the resin of D. draco, with anti-inflammatory, and pro-proliferative as well as antimicrobial activitie

The dynamical mass of the white dwarf in XY Ari questions intermediate polar X-ray spectral models

We present a dynamical study of the eclipsing intermediate polar XY Ari based on time-resolved near-infrared spectroscopy obtained with the EMIR spectrograph on the 10.4-m Gran Telescopio Canarias. Using main sequence template spectra taken with the same instrument setup as the target spectra, we measure a radial velocity amplitude of the late K-type donor star $K_2=256 \pm 2$ km s$^{-1}$. We also obtain the rotational broadening of its photospheric lines $v_\mathrm{rot} \sin i = 141 \pm 3$ km s$^{-1}$. From these and the eclipse geometry, we derive a donor-to-white dwarf mass ratio $q = M_2/M_1 = 0.62 \pm 0.02$, an orbital inclination $i = 80.8^{\circ} \pm 0.5^{\circ}$ and dynamical masses $M_{1} = 1.21 \pm 0.04 \, \mathrm{M}_{\odot}$ and $M_2 = 0.75 \pm 0.04 \, \mathrm{M}_{\odot}$ ($1 \sigma$). This result places the white dwarf in XY Ari as one of the three most massive known in a cataclysmic variable. Comparison with a number of white dwarf mass estimates from X-ray spectral modelling indicates the necessity of a major revision of the cooling models currently assumed for magnetic accretion in intermediate polars, as most of the X-ray white dwarf masses lie significantly below the dynamical mass value.Comment: 9 pages, 4 figures, 5 tables, submitted for publication in MNRA

Optical and near-infrared spectroscopy of the black hole transient 4U 1543-47 during its 2021 ultra-luminous state

We present simultaneous optical and near-infrared spectra obtained during the 2021 outburst of the black hole transient 4U 1543-47. The X-ray hardness-intensity diagram and the comparison with similar systems reveal a luminous outburst, probably reaching the Eddington luminosity, as well as a long-lasting excursion to the so-called ultra-luminous state. VLT/X-shooter spectra were taken in two epochs 14 days apart during the early and brightest part of the outburst, while the source was in this ultra-luminous accretion state. The data show strong H and HeI emission lines, as well as high-excitation HeII and OIII transitions. Most lines are single-peaked in both spectra, except for the OIII lines that exhibit evident double-peaked profiles during the second epoch. The Balmer lines are embedded in broad absorption wings that we believe are mainly produced by the contribution of the A2V donor to the optical flux, which we estimate to be in the range of 11 to 14 per cent in the $r$ band during our observations. Although no conspicuous outflow features are found, we observe some wind-related line profiles, particularly in the near-infrared. Such lines include broad emission line wings and skewed red profiles, suggesting the presence of a cold (i.e. low ionisation) outflow with similar observational properties to those found in other low-inclination black hole transients.Comment: Accepted for publication in A&

Discovery of optical outflows and inflows in the black hole candidate GRS 1716-249

We present optical spectroscopy obtained with the GTC, VLT and SALT telescopes during the decline of the 2016-2017 outburst of the black hole candidate GRS 1716-249 (Nova Oph 1993). Our 18-epoch data set spans 6 months and reveals that the observational properties of the main emission lines are very variable, even on time scales of a few hours. Several epochs are characterised by P-Cyg (as well as flat-top and asymmetric) profiles in the H$\alpha$, H$\beta$ and He II ($\lambda$4686) emission lines, implying the presence of an accretion disc wind, which is likely hot and dense. The wind's terminal velocity ($\sim$2000 km s$^{-1}$) is similar to that observed in other black hole X-ray transients. These lines also show transient and sharp red-shifted absorptions, taking the form of inverted P-Cyg profiles. We argue that these profiles can be explained by the presence of infalling material at $\sim$1300 km s$^{-1}$. We propose a failed wind scenario to explain this inflow and discuss other alternatives, such as obscuration produced by an accretion-related structure (e.g. the gas stream) in a high inclination system.Comment: Published in MNRAS main journa

Adrenomedullin as a potential biomarker involved in patients with hereditary hemorrhagic telangiectasia

Background: Adrenomedullin (AM) is a vasoactive peptide mostly secreted by endothelial cells with an important role in preserving endothelial integrity. The relationship between AM and hereditary hemorrhagic telangiectasia (HHT) is unknown. We aimed to compare the serum levels and tissue expression of AM between HHT patients and controls. Methods: Serum AM levels were measured by radioimmunoassay and compared between control and HHT groups. AM levels were also compared among HHT subgroups according to clinical characteristics. The single nucleotide polymorphism (SNP) rs4910118 was assessed by restriction analysis and sequencing. AM immunohistochemistry was performed on biopsies of cutaneous telangiectasia from eight HHT patients and on the healthy skin from five patients in the control group. Results: Forty-five HHT patients and 50 healthy controls were included, mean age (SD) was 50.7 (14.9) years and 46.4 (9.9) years (p = 0.102), respectively. HHT patients were mostly female (60% vs 38%, p = 0.032). Median [Q1-Q3] serum AM levels were 68.3 [58.1-80.6] pg/mL in the HHT group and 47.7 [43.2-53.8] pg/mL in controls (p<0.001), with an optimal AM cut-off according to Youden's J statistic of 55.32 pg/mL (J:0.729). Serum AM levels were similar in the HHT subgroups. No patient with HHT had the SNP rs4910118. AM immunoreactivity was found with high intensity in the abnormal blood vessels of HHT biopsies