X-ray observations of a flare in NGC4151 from OSO-8

The 2-60 keV flux from NGC4151 changed by a factor of two on a timescale of 1.5 days. No fluctuations were detected in excess of a factor of three on timescales less than four hours. During a total observation of approximately 11 days there were no statistically significant changes in spectral shape. The spectrum was fitted by a power law with photon index alpha approximately 1.42 + or - 0.06 and column density N sub H approximately 7.5 + or - 0.5 x 10 to the 22d power at/cu cm. A 2 sigma residual to this fit implies fluorescent Fe line emission with E. W. approximately 240 eV. Both synchrotron self-Compton and thermal Compton models are consistent with the X-ray data

Revisiting biomarker discovery by plasma proteomics

Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate. As described in this review, mass spectrometry (MS)-based proteomics has become a powerful technology in biological research and it is now poised to allow the characterization of the plasma proteome in great depth. Previous "triangular strategies" aimed at discovering single biomarker candidates in small cohorts, followed by classical immunoassays in much larger validation cohorts. We propose a "rectangular" plasma proteome profiling strategy, in which the proteome patterns of large cohorts are correlated with their phenotypes in health and disease. Translating such concepts into clinical practice will require restructuring several aspects of diagnostic decision-making, and we discuss some first steps in this direction

Evaluation of Distance Measures Between Gaussian Mixture Models of MFCCs

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Evaluation Distance Measures Between Gaussian Mixture Models of MFCCs

In music similarity and in the related task of genre classification, a distance measure between Gaussian mixture models is frequently needed. We present a comparison of the Kullback-Leibler distance, the earth movers distance and the normalized L2 distance for this application. Although the normalized L2 distance was slightly inferior to the Kullback-Leibler distance with respect to classification performance, it has the advantage of obeying the triangle inequality, which allows for efficient searching

A new framework for evaluating dust emission model development using dichotomous satellite observations of dust emission

Dust models are essential for understanding the impact of mineral dust on Earth's systems, human health, and global economies, but dust emission modelling has large uncertainties. Satellite observations of dust emission point sources (DPS) provide a valuable dichotomous inventory of regional dust emissions. We develop a framework for evaluating dust emission model performance using existing DPS data before routine calibration of dust models. To illustrate this framework's utility and arising insights, we evaluated the albedo-based dust emission model (AEM) with its areal (MODIS 500 m) estimates of soil surface wind friction velocity (u(s*)) and common, poorly constrained grain-scale entrainment threshold (u(*ts)) adjusted by a function of soil moisture (H). The AEM simulations are reduced to its frequency of occurrence, P(u(s*) > u(*ts)H). The spatio-temporal variability in observed dust emission frequency is described by the collation of nine existing DPS datasets. Observed dust emission occurs rarely, even in North Africa and the Middle East, where DPS frequency averages 1.8 %, (similar to 7 days y(-1)), indicating extreme, large wind speed events. The AEM coincided with observed dust emission similar to 71.4 %, but simulated dust emission similar to 27.4 % when no dust emission was observed, while dust emission occurrence was over-estimated by up to 2 orders of magnitude. For estimates to match observations, results showed that grain- scale u(*ts) needed restricted sediment supply and compatibility with areal u(s*). Failure to predict dust emission during observed events, was due to u(s*) being too small because reanalysis winds (ERA5-Land) were averaged across 11 km pixels, and inconsistent with u(s*)across 0.5 km pixels representing local maxima. Assumed infinite sediment supply caused the AEM to simulate dust emission whenever P(u(s*)>u(*ts)H), producing false positives when wind speeds were large. The dust emission model scales of existing parameterisations need harmonising and a new parameterisation for u(*ts) is required to restrict sediment supply over space and time

Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer

Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimidine, oxaliplatin and bevacizumab to test whether HPP1 mfcDNA is a suitable prognostic and response biomarker. From 467 patients of the prospective clinical study AIO-KRK-0207, mfcDNA was isolated from plasma samples at different time points and bisulfite-treated mfcDNA was quantified using methylation specific PCR. About 337 of 467 patients had detectable levels for HPP1 mfcDNA before start of treatment. The detection was significantly correlated with poorer overall survival (OS) (HR = 1.86; 95%CI 1.37-2.53). About 2-3 weeks after the first administration of combination chemotherapy, HPP1 mfcDNA was reduced to non-detectable levels in 167 of 337 patients. These patients showed a better OS compared with patients with continued detection of HPP1 mfcDNA (HR HPP1(sample 1: pos/ sample 2: neg) vs. HPP1(neg/neg) = 1.41; 95%CI 1.00-2.01, HPP1(neg,pos/pos) vs. HPP1(neg/neg) = 2.60; 95%CI 1.86-3.64). Receiver operating characteristic analysis demonstrated that HPP1 mfcDNA discriminates well between patients who do (not) respond to therapy according to the radiological staging after 12 or 24 weeks (AUC = 0.77 or 0.71, respectively). Detection of HPP1 mfcDNA can be used as a prognostic marker and an early marker for response (as early as 3-4 weeks after start of treatment compared with radiological staging after 12 or 24 weeks) to identify patients who will likely benefit from a combination chemotherapy with bevacizumab.info:eu-repo/semantics/publishedVersio