Исследование влияния технологических параметров процесса селективного лазерного сплавления на макроструктуру образцов из титановых сплавов

Установлены режимы селективного лазерного сплавления, которые обеспечивают наименьшее количество макродефектов в образцах размером 5х5 мм, полученных сплавлением порошка титана ВТ1-0 и композиционного порошка TiC-Al. Установленные режимы селективного лазерного сплавления используются в рамках выполнения НИР "Исследование влияния технологических параметров процесса селективного лазерного сплавления на макроструктуру образцов из титановых сплавов", выполняемой в Научно-производственной лаборатории "Современные производственные технологии" НИ ТПУ.Modes of selective laser fusion are established, which provide the smallest number of macrodefects in samples 5 ? 5 mm in size obtained by fusion of VT1-0 titanium powder and TiC-Al composite powder. The established regimes of selective laser fusion are used as part of the R&D "Study of the influence of technological parameters of the selective laser fusion process on the macrostructure of samples made of titanium alloys", performed at the Scientific and Production Laboratory "Modern Production Technologies" of TPU

Increased Number of Cerebellar Granule Cells and Astrocytes in the Internal Granule Layer in Sheep Following Prenatal Intra-amniotic Injection of Lipopolysaccharide

Chorioamnionitis is an important problem in perinatology today, leading to brain injury and neurological handicaps. However, there are almost no data available regarding chorioamnionitis and a specific damage of the cerebellum. Therefore, this study aimed at determining if chorioamnionitis causes cerebellar morphological alterations. Chorioamnionitis was induced in sheep by the intra-amniotic injection of lipopolysaccharide (LPS) at a gestational age (GA) of 110 days. At a GA of 140 days, we assessed the mean total and layer-specific volume and the mean total granule cell (GCs) and Purkinje cell (PC) number in the cerebelli of LPS-exposed and control animals using high-precision design-based stereology. Astrogliosis was assessed in the gray and white matter (WM) using a glial fibrillary acidic protein staining combined with gray value image analysis. The present study showed an unchanged volume of the total cerebellum as well as the molecular layer, outer and inner granular cell layers (OGL and IGL, respectively), and WM. Interestingly, compared with controls, the LPS-exposed brains showed a statistically significant increase (+20.4%) in the mean total number of GCs, whereas the number of PCs did not show any difference between the two groups. In addition, LPS-exposed animals showed signs of astrogliosis specifically affecting the IGL. Intra-amniotic injection of LPS causes morphological changes in the cerebellum of fetal sheep still detectable at full-term birth. In this study, changes were restricted to the inner granule layer. These cerebellar changes might correspond to some of the motor or non-motor deficits seen in neonates from compromised pregnancies

Insulin Binding to Erythrocytes before and after Changing from Porcine to Biosynthetic Human Insulin in Children with Type-I Diabetes

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Insulin Binding to Erythrocytes in Children with Type-I Diabetes mellitus

Peer Reviewe