72 research outputs found
Monitoring of Cell Layer Integrity with a Current-Driven Organic Electrochemical Transistor
No full textThe integrity of CaCo-2 cell barriers is investigated by organic electrochemical transistors (OECTs) in a current-driven configuration. Ion transport through cellular barriers via the paracellular pathway is modulated by tight junctions between adjacent cells. Rupturing its integrity by H2O2 is monitored by the change of the output voltage in the transfer characteristics. It is demonstrated that by operating the OECT in a current-driven configuration, the sensitive and temporal resolution for monitoring the cell barrier integrity is strongly enhanced as compared to the OECT transient response measurement. As a result, current-driven OECTs are useful tools to assess dynamic and critical changes in tight junctions, relevant for clinical applications as drug targeting and screening
Monitoring Reversible Tight Junction Modulation with a Current-Driven Organic Electrochemical Transistor
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An Iontronic Multiplexer Based on Spatiotemporal Dynamics of Multiterminal Organic Electrochemical Transistors
Get PDFHigh‐Performance Bioelectronic Circuits Integrated on Biodegradable and Compostable Substrates with Fully Printed Mask‐Less Organic Electrochemical Transistors
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High‐Performance Organic Electrochemical Transistors and Neuromorphic Devices Comprising Naphthalenediimide‐Dialkoxybithiazole Copolymers Bearing Glycol Ether Pendant Groups
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