OncoLog Volume 51, Number 01, January 2006

Fertility After Cancer Improving the Odds in Lung Cancer House Call: Understanding the Basics of Melanomahttps://openworks.mdanderson.org/oncolog/1177/thumbnail.jp

OncoLog Volume 53 Number 12, December 2008

Mantle Cell Lymphoma Sparing the Nipple During Mastectomy House Call: Taking Medicine? Be Aware of Food-Drug Interactionshttps://openworks.mdanderson.org/oncolog/1176/thumbnail.jp

OncoLog Volume 41, Number 02, April-June 1996

lntraoperative lymphatic mapping elegant way to identify lymph node metastases in melanoma patients New Patient Referral Office changes with M. D. Anderson\u27s referral policy Combined chemotherapy and radiation therapy bringing hope for inoperable lung cancerhttps://openworks.mdanderson.org/oncolog/1054/thumbnail.jp

Spitzer/MIPS 24 μm Observations of HD 209458b: Three Eclipses, Two and a Half Transits, and a Phase Curve Corrupted by Instrumental Sensitivity Variations

We report the results of an analysis of all Spitzer/MIPS 24 μm observations of HD 209458b, one of the touchstone objects in the study of irradiated giant planet atmospheres. Altogether, we analyze two and a half transits, three eclipses, and a 58 hr near-continuous observation designed to detect the planet's thermal phase curve. The results of our analysis are: (1) a mean transit depth of 1.484% ± 0.033%, consistent with previous measurements and showing no evidence of variability in transit depth at the 3% level. (2) A mean eclipse depth of 0.338% ± 0.026%, somewhat higher than that previously reported for this system; this new value brings observations into better agreement with models. From this eclipse depth we estimate an average dayside brightness temperature of 1320 ± 80 K; the dayside flux shows no evidence of variability at the 12% level. (3) Eclipses in the system occur 32 ± 129 s earlier than would be expected from a circular orbit, which constrains the orbital quantity ecos ω to be 0.00004 ± 0.00033. This result is fully consistent with a circular orbit and sets an upper limit of 140 m s^(–1) (3σ) on any eccentricity-induced velocity offset during transit. The phase curve observations (including one of the transits) exhibit an anomalous trend similar to the detector ramp seen in previous Spitzer/IRAC observations; by modeling this ramp we recover the system parameters for this transit. The long-duration photometry which follows the ramp and transit exhibits a gradual ~0.2% decrease in flux over ~30 hr. This effect is similar to that seen in pre-launch calibration data taken with the 24 μm array and is better fit by an instrumental model than a model invoking planetary emission. The large uncertainties associated with this poorly understood, likely instrumental effect prevent us from usefully constraining the planet's thermal phase curve. Our observations highlight the need for a thorough understanding of detector-related instrumental effects on long timescales when making the high-precision mid-infrared measurements planned for future missions such as EChO, SPICA, and the James Webb Space Telescope

Molecular Signatures in the Near Infrared Dayside Spectrum of HD 189733b

We have measured the dayside spectrum of HD 189733b between 1.5 and 2.5 microns using the NICMOS instrument on the Hubble Space Telescope. The emergent spectrum contains significant modulation, which we attribute to the presence of molecular bands seen in absorption. We find that water (H2O), carbon monoxide (CO), and carbon dioxide (CO2) are needed to explain the observations, and we are able to estimate the mixing ratios for these molecules. We also find temperature decreases with altitude in the ~0.01 < P < ~1 bar region of the dayside near-infrared photosphere and set an upper limit to the dayside abundance of methane (CH4) at these pressures.Comment: 13 pages, 3 figures. accepted in Astrophysical Journal Letter

Thermal Phase Variations of WASP-12b: Defying Predictions

[Abridged] We report Warm Spitzer full-orbit phase observations of WASP-12b at 3.6 and 4.5 micron. We are able to measure the transit depths, eclipse depths, thermal and ellipsoidal phase variations at both wavelengths. The large amplitude phase variations, combined with the planet's previously-measured day-side spectral energy distribution, is indicative of non-zero Bond albedo and very poor day-night heat redistribution. The transit depths in the mid-infrared indicate that the atmospheric opacity is greater at 3.6 than at 4.5 micron, in disagreement with model predictions, irrespective of C/O ratio. The secondary eclipse depths are consistent with previous studies. We do not detect ellipsoidal variations at 3.6 micron, but our parameter uncertainties -estimated via prayer-bead Monte Carlo- keep this non-detection consistent with model predictions. At 4.5 micron, on the other hand, we detect ellipsoidal variations that are much stronger than predicted. If interpreted as a geometric effect due to the planet's elongated shape, these variations imply a 3:2 ratio for the planet's longest:shortest axes and a relatively bright day-night terminator. If we instead presume that the 4.5 micron ellipsoidal variations are due to uncorrected systematic noise and we fix the amplitude of the variations to zero, the best fit 4.5 micron transit depth becomes commensurate with the 3.6 micron depth, within the uncertainties. The relative transit depths are then consistent with a Solar composition and short scale height at the terminator. Assuming zero ellipsoidal variations also yields a much deeper 4.5 micron eclipse depth, consistent with a Solar composition and modest temperature inversion. We suggest future observations that could distinguish between these two scenarios.Comment: 19 pages, 10 figures, ApJ in press. Improved discussion of gravity brightenin

Inventory Management of Platelets in Hospitals: Optimal Inventory Policy for Perishable Products with Emergency Replenishments

Platelets are short-life blood components used in hospital blood transfusion centers. Excluding time for transportation, testing, and arrangement, clinically transfusable platelets have a mere three-day life-span. This paper analyzes a periodic review inventory system for such perishable products under two replenishment modes. Regular orders are placed at the beginning of a cycle. Within the cycle, the manager has the option of placing an emergency order, characterized by an order-up-to level policy. We prove the existence and uniqueness of an optimal policy that minimizes the expected cost. We then derive the necessary and sufficient conditions for the policy, based on which a heuristic algorithm is developed. A numerical illustration and a sensitivity analysis are provided, along with managerial insights. The numerical results show that, unlike typical inventory problems, the total expected cost is sensitive to the regular order policy. It also shows that the optimal policy is sensitive to changes in the expected demand, suggesting to decision makers the significance of having an accurate demand forecast

Chronic antibiotic use during adulthood and weight change in the Sister Study

Background/Objectives: Antibiotic use in early life has been associated with weight gain in several populations. However, associations between chronic antibiotic use and weight among adults in the general population are unknown. Subjects/Methods: The NIEHS Sister Study is a longitudinal cohort of sisters of women with breast cancer. We examined associations between chronic antibiotic use (>= 3 months) during the fourth decade of life (30-39 years) and subsequent obesity at enrollment (mean age = 55) via logistic regression. We also examined associations between chronic antibiotic use in the 5 years and 12 months prior to enrollment and weight gain after enrollment in linear mixed models. Models were adjusted for race/ethnicity, education, urban/rural status, age, and smoking. Results: In adjusted analyses (n = 50,237), chronic penicillin use during the 4 th decade of life was associated with obesity at enrollment (OR 2.00, 95% CI 1.40, 2.87), and use in the 5 years prior to enrollment was associated with increased BMI change after enrollment (beta 1.00 95% CI 0.01, 2.00). Use of bactericidals (OR 1.71, 95% CI 1.29, 2.26) during the 4 th decade of life was also associated with obesity at enrollment. Associations for penicillins and bactericidals were consistent across indications for use. Bacteriostatic use in the 5 years prior to enrollment was associated with a reduction in BMI after enrollment (beta -0.52, 95% CI -1.04, 0.00), and tetracycline use during the 4 th decade of life was associated with reduced odds of obesity at enrollment (OR 0.72, 95% CI 0.56, 0.92). However, these inverse associations were only present for those who reported taking antibiotics for skin purposes. Cephalosporins, macrolides, quinolones, and sulfonamides were not associated with BMI change over time. Conclusions: Chronic use of antibiotics during adulthood may have long-lasting impacts on BMI. Associations may differ by antibiotic class, and confounding by indication may be important for some antibiotic classes.Intramural Research Program of the NIH, National Institute of Environmental Sciences [Z01ES044005]; NIEHS [T32ES007018, K99ES028743]; NIHOpen access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

OncoLog Volume 40, Number 01 January-March 1995

Genetic testing: a new paradigm for medullary thyroid carcinoma Bone marrow transplantation now available as an outpatient procedure Adjuvant chemotherapy for breast cancer: 20 years of progress at M. D. Andersonhttps://openworks.mdanderson.org/oncolog/1049/thumbnail.jp

OncoLog Volume 41, Number 01, January-March 1996

Malignant brain tumors a new target for gene therapy Benign pituitary tumors threaten endocrine and nervous systems New guidebook helps patients and caregivers cope with advanced cancerhttps://openworks.mdanderson.org/oncolog/1053/thumbnail.jp