An analysis of software aging in cloud environment

Cloud Computing is the environment in which several virtual machines (VM) run concurrently on physical machines. The cloud computing infrastructure hosts multiple cloud service segments that communicate with each other using the interfaces. This creates distributed computing environment. During operation, the software systems accumulate errors or garbage that leads to system failure and other hazardous consequences. This status is called software aging. Software aging happens because of memory fragmentation, resource consumption in large scale and accumulation of numerical error. Software aging degrads the performance that may result in system failure. This happens because of premature resource exhaustion. This issue cannot be determined during software testing phase because of the dynamic nature of operation. The errors that cause software aging are of special types. These errors do not disturb the software functionality but target the response time and its environment. This issue is to be resolved only during run time as it occurs because of the dynamic nature of the problem. To alleviate the impact of software aging, software rejuvenation technique is being used. Rejuvenation process reboots the system or re-initiates the softwares. This avoids faults or failure. Software rejuvenation removes accumulated error conditions, frees up deadlocks and defragments operating system resources like memory. Hence, it avoids future failures of system that may happen due to software aging. As service availability is crucial, software rejuvenation is to be carried out at defined schedules without disrupting the service. The presence of Software rejuvenation techniques can make software systems more trustworthy. Software designers are using this concept to improve the quality and reliability of the software. Software aging and rejuvenation has generated a lot of research interest in recent years. This work reviews some of the research works related to detection of software aging and identifies research gaps

Enzymatic oligomerization and polymerization of arylamines: state of the art and perspectives

The literature concerning the oxidative oligomerization and polymerization of various arylamines, e.g., aniline, substituted anilines, aminonaphthalene and its derivatives, catalyzed by oxidoreductases, such as laccases and peroxidases, in aqueous, organic, and mixed aqueous organic monophasic or biphasic media, is reviewed. An overview of template-free as well as template-assisted enzymatic syntheses of oligomers and polymers of arylamines is given. Special attention is paid to mechanistic aspects of these biocatalytic processes. Because of the nontoxicity of oxidoreductases and their high catalytic efficiency, as well as high selectivity of enzymatic oligomerizations/polymerizations under mild conditions-using mainly water as a solvent and often resulting in minimal byproduct formation-enzymatic oligomerizations and polymerizations of arylamines are environmentally friendly and significantly contribute to a "green'' chemistry of conducting and redox-active oligomers and polymers. Current and potential future applications of enzymatic polymerization processes and enzymatically synthesized oligo/polyarylamines are discussed

Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds

Invasion is the hallmark of malignant tumors, and is responsible for the bad prognosis of the untreated cancer patients. The search for anti-invasive treatments led us to screen compounds of different classes for their effect in an assay for invasion. Thirty-nine new compounds synthesized in the present study along with 56 already reported compounds belonging mainly to the classes of lactones, pyrazoles, isoxazoles, coumarins, desoxybenzoins, aromatic ketones, chalcones, chromans, isoflavanones have been tested against organotypic confronting cultures of invasive human MCF-7/6 mammary carcinoma cells with embryonic chick heart fragments in vitro. Three of them (a pyrazole derivative, an isoxazolylcoumarin and a prenylated desoxybenzoin) inhibited invasion at concentrations as low as 1 muM; instead of occupying and replacing the heart tissue within 8 days, the MCF-7/6 cells grew around the heart fragments and left it intact, when treated with these compounds. At the anti-invasive concentration of 1 muM, the three compounds did not affect the growth of the MCF-7/6 cells, as shown in the sulforhodamine B assay. Aggregate formation on agar was not stimulated by any of the three anti-invasive compounds, making an effect on the E-cadherin/catenin complex improbable. This is an invasion suppressor that can be activated in MCF-7/6 cells by a number of other molecules. Our data indicate that some polyphenolic and heterocyclic compounds are anti-invasive without being cytotoxic for the cancer cells. (C) 2003 Elsevier Science Ltd. All rights reserved