Technique automated of diagram construction in business process management systems

Technique allowing reducing stages of analysis and design of application while implementing Business Process Management System (BPMS) has been suggested. It was possible due to elimination of enterprise activity examination stage and formation of business process models on the basis of structural functional models obtained as a result of reengineering project or developing quality management system. The required steps of model construction in BPMS were revealed. Appropriateness of business process modeling with the help of traditional meansand further use of models for transfer into BPMS by conversion was validated. Algorithm of automated transformation on the basis of processing XML-files of models was suggeste

Migration Processes Modeling with Cellular Automation

Abstract. The problem of interregional migration flows modeling is being studied. The conjecture that modeling household migration behavior at local level in view of community interactions and using cellular automata results in adequate forecasting of interregional migration flows has been numerically confirmed. A computer program was developed in order to implement the cellular automaton suggested in this study, which models interregional migration flows. Cellular automaton program was tested on Primorsky krai migration flows statistical data; a short-term forecast of the region migration flows was obtained

Spectacular enhancement of the thermal and photochemical stability of mapbi3 perovskite films using functionalized tetraazaadamantane as a molecular modifier

Perovskite solar cells represent a highly promising third-generation photovoltaic tech-nology. However, their practical implementation is hindered by low device operational stability, mostly related to facile degradation of the absorber materials under exposure to light and elevated temperatures. Improving the intrinsic stability of complex lead halides is a big scientific challenge, which might be addressed using various “molecular modifiers”. These modifiers are usually rep-resented by some additives undergoing strong interactions with the perovskite absorber material, resulting in enhanced solar cell efficiency and/or operational stability. Herein, we present a deriva-tive of 1,4,6,10-tetraazaadamantane, NAdCl, as a promising molecular modifier for lead halide perovskites. NAdCl spectacularly improved both the thermal and photochemical stability of methy-lammonium lead iodide (MAPbI3 ) films and, most importantly, prevented the formation of metallic lead Pb0 as a photolysis product. NAdCl improves the electronic quality of perovskite films by healing the traps for charge carriers. Furthermore, it strongly interacts with the perovskite framework and most likely stabilizes undercoordinated Pb2+ ions, which are responsible for Pb0 formation under light exposure. The obtained results feature 1,4,6,10-tetraazaadamantane derivatives as highly promising molecular modifiers that might help to improve the operational lifetime of perovskite solar cells and facilitate the practical implementation of this photovoltaic technology. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.This work was supported by Russian Science Foundation (project No. 19-73-30020). The XPS measurements were supported by the Ministry of Education and Science of the Russian Federation (project FEUZ-2020-0060), Theme ‘Electron’, no. AAAA-A18-118020190098-5 and Russian Foundation for Basic Research (project No. 21-52-52002)

Usage of Learning Management System Web Analytics in Blended Learning Self-Study Evaluation

Learning Management System (LMS) analytics data is proposed to be used in developing algorithms for evaluating students’ self-studies. Development of such algorithms is relevant considering annual growth of disciplines that apply blended learning. In blended learning model selfstudy can be done online in LMS which makes it possible to analyze patterns how students interact with learning materials and perform exercises of various complexity. Different criteria and indicators are aggregated into numeric metrics that following designed methodology evaluates self-study performance of each student. Designed methodology uses algorithms that evaluate self-study results by using empirical LMS analytics data. Developed algorithms allow us on one hand to interpret empirical data for self-studies evaluation, and on the other hand to correct and improve students’ learning path. This paper presents results of using developed methodology deployed in LMS BlackBoard on the example of Information Technology blended learning course in Far Eastern Federal University

Carbohydrate metabolism parameters in angina patients treated with metoprolol and its combination with trimetazidine

Aim. To study the effects of a β-adrenoblocker (β-AB) metoprolol (Mp) and its combination with trimetazidine (Tmd) on glucose tolerance and insulin sensitivity in patients with angina pectoris. Material and methods. In total, 28 men aged 46-68 years, with Functional Class (FC) II-III stable angina, positive exercise stress test (EST), and no prior β-AB therapy were examined. Individual Mp doses were selected based on the paired EST results. For one month, the Mp dose of 50 or 100 mg/d was administered twice a day; for the next month, participants received Mp and Tmd (70 mg/d). A standard glucose tolerance test (GTT) was performed at baseline and at the end of one-month periods of Mp or Mp + Tmd treatment. Carbohydrate metabolism disturbances were diagnosed according to the WHO criteria (1999). Insulin resistance (IR) was assessed by HOMA2-IR parameter, and tissue insulin sensitivity by ISI0,120 parameter. Results. After one month of Mp treatment, a decrease in fasting glucose levels was observed (p=0,025). At the same time, the GTT results demonstrated increased glucose levels 2 hours after glucose load, compared to baseline (p=0,049). Tissue insulin sensitivity (ISI0,120) showed some reduction (p=0,14), while the number of patients with impaired glucose tolerance (IGT) increased from 4 to 8 (p=0,006). The levels of fasting and post-load glycemia after one month of the combination therapy with Mp and Tmd were similar to those after the Mp treatment. Insulin levels at 2 hours after glucose load were higher than those observed after the Mp therapy (p=0,045). Compared to baseline, HOMA2-IR values increased, and IDI0,120 values decreased (p=0,036). The IDI0,120 dynamics suggested a reduction in insulin sensitivity for both treatment regimens. IGT was registered in 10 patients. Conclusion. In angina patients, impaired glucose control was observed as early as 1 month after the start of Mp treatment. This early impairment could be diagnosed by GTT. Although the combination therapy with Mp and Tmd did not prevent this impairment, but provided a greater antiischemic effect and, therefore, was clinically appropriat

Antiischemic effects of metoprolol and the risk of carbohydrate metabolism disturbances in angina patients

Aim. To study the association between antiischemic effects (AIE) of metoprolol (MP), glucose tolerance, and insulin sensitivity in patients with stable angina (SA). Material and methods. The study included 28 male patients, aged 46-68 years, with stable effort angina, Functional Class II-III, and positive exercise stress test (EST). The time of the ST segment depression by ≥1 mm defined the threshold exercise stress time. MP in a selected dose was administered twice a day, for one month. Its hemodynamic effects were assessed by the dynamics of heart rate (HR), blood pressure (BP), and double product (DP). Glucose tolerance test (GTT) was performed at baseline (before MP administration) and after one month of MP treatment. Tissue insulin sensitivity and insulin resistance (IR) were assessed by ISI0.120 and HOMA-IR parameters, respectively. Results. AIE was registered in 57% of the patients, while 43% failed to demonstrate it. Both groups did not differ by the extent of MP impact on the levels of HR, BP, and DP. The presence or absence of AIE was linked to selected parameters of glucose metabolism. In patients with AIE, the pre-treatment levels of glucose and insulin 2 hours after glucose load were higher (p=0,028 and 0,043, respectively) and ISI1,120 values lower than in patients without AIE (p=0,023). Among participants with AIE, impaired glucose tolerance (IGT) was observed in 4 at baseline and in 8 one month later; among patients without AIE, IGT was not registered. Conclusion. For the first time, the presence of AIE during MP therapy of SA patients was linked to the decreased insulin sensitivity of peripheral tissues (ISI0.120). Paired EST with a single MP dose at baseline provides an opportunity to identify the patients with a higher risk of metabolic disturbances during the longer-term MP treatment

Особенности течения саркоидоза у больных с персистированием зернистых форм микобактерий

The aim of this study was to determine an influence of granular mycobacteria on sarcoidosis course, to develop the most effective treatment schemes and to evaluate treatment delayed results.Granular mycobacteria were found in blood, sputum and broncho-alveolar washings of 57 % of sarcoidosis patients and 65 % of tuberculosis ones. Granular mycobacteria were revealed using highly sensitive specific staining by fluorochrome dyes and luminescent microscopy. Those microorganisms were painted like acid-stable Micobacteria tuberculosis from small-granular forms to large-granular ones (0.1 to 0.8 m cm in a diameter).Granular mycobacteria were looked for in 93 sarcoidosis patients. They were revealed in 59 patients and were not revealed in 34 ones. Granular mycobacteria have been detected most often in sarcoidosis patients with wide spread forms, extra pulmonary lesions and reccurent course . An analysis of treatment results of sarcoidosis patients in remote period demonstrated that they were significantly worse in patients with presence of granular mycobacteria using both basic therapy (steroids) and combination with plasma pheresis. Granular mycobacteria were considered to be a burden in the disease course and require further improvement in treatment methodics.ЗФМБ были обнаружены в крови, мокроте и БАС у 57% больных саркоидозом и 65% туберкулезом. ЗФМБ обнаруживались при применении высокочувствительной специфической окраски флюорохромными красителями илюминесцентной микроскопии. Указанные микроорганизмы воспринимали красители аналогично кислотоустойчивым микобактериям туберкулеза от мелкозернистых форм до крупнозернистых (от 0,1 до 0,8 мкм в диаметре).Поиск ЗФМБ был проведен у 93 больных саркоидозом. У 59 больных были обнаружены ЗФМБ, у 34 — не были обнаружены. Наиболее часто ЗФМБ обнаруживаются у больных саркоидозом с распространенными формами, с внелегочным поражением и рецидивирующим течением. Анализ результатов лечения больных саркоидозом в отдаленные сроки наблюдения показал, что как при базисной терапии (гормоны), так и при комбинированной с использованием плазмафереза они значительно ниже у больных с обнаружением ЗФМБ. ЗФМБ у больных саркоидозом являются отягощающим фактором течения болезни и требуют продолжать совершенствовать методы лечения