5 research outputs found
Alterações pulmonares cintilográficas e espirométricas em pacientes jovens portadores de esquistossomose mansônica tratados clínica e cirurgicamente na infância
OBJETIVOS: O presente estudo teve por objetivo analisar as alterações pulmonares de pacientes portadores de esquistossomose hepatoesplênica, tratados clínica e cirurgicamente, através da cintilografia pulmonar de perfusão e espirometria. MÉTODO: Trinta pacientes jovens portadores de esquistossomose mansônica hepatoesplênica, previamente tratados clínica e cirurgicamente, se submeteram a cintilografia pulmonar de perfusão e avaliação da capacidade respiratória pela espirometria. RESULTADOS: Ao exame cintilográfico, constataram-se alterações em 33,3% dos pacientes e padrão restritivo pulmonar em 30% das espirometrias. CONCLUSÕES: A prevalência do acometimento pulmonar, avaliado pela Medicina Nuclear, se situou abaixo do observado em pacientes não tratados, relatados na literatura. O padrão restritivo pulmonar, entretanto, avaliado pela espirometria, foi elevado e merece atenção especial no seguimento e manuseio desses pacientes
Autotransplant of Spleen Tissue in Children with Schistosomiasis: Evaluation of Splenic Function after Splenosis
Autotransplantation of spleen tissue has been done, in the past ten
years, in children with schistosomiasis mansoni with bleeding varices.
The purposes of this investigation were: (1) to study the morphology
and function of the remnant spleen tissue; (2) to quantify the
production of tuftsin; and (3) to assess the immune response to
pneomococcal vaccine of these patients. Twenty three children, who
underwent splenectomy and autologous implantation of spleen tissue into
the greater omentum were included in this investigation. The average
postoperative follow-up is five years. Splenosis was proved by colloid
liver-spleen scans. Search for Howell-Jolly bodies assessed the
filtration function. Tuftsin and the titer of pneumococcal antibodies
were quantified by ELISA. Splenosis was evident in all children;
however, it was insufficient in two. Howell-Jolly bodies were found
only in these two patients. The mean tuftsin serum concentration (335.0
± 29.8 ng/ml) was inside the normal range. The immune response to
pneumococcal vaccination was adequate in 15 patients; intermediate in
four; and inadequate in four. From the results the following
conclusions can be drawn: splenosis was efficient in maintaining the
filtration splenic function in more than 90% and produced tuftsin
inside the range of normality. It also provided the immunologic splenic
response to pneumococcal vaccination in 65% of the patients of this
series