Factors of a Sense of Authenticity and Their Influence on Psychological Well-being in Adolescence

In this study, we aimed to examine the factors that contribute to the formation of a sense of authenticity and the process by which a sense of authenticity is formed. First, we examined the relationship between a sense of authenticity and a sense of superiority in relation to psychological well-being among 221 university students. The results showed that a sense of authenticity is more significant for psychological well-being than a sense of superiority and helps form adaptive self-esteem. In addition, the results of the study regarding how to make meaning from past experiences show that reconsidering experiences has a positive impact on the establishment of identity. Second, interviews were conducted with 10 university students and analyzed using Trajectory Equifinality Model (TEM). As a result, we found that there are four factors that contribute to the formation of a sense of authenticity awareness of one’s true self, forming one’s own identity based on personal value standards, struggling with one’s inner self, and breaking free from the “captivity” of clinging beliefs. Thus, we suggest that these are the factors and processes that lead to the formation of a sense of authenticity

Statistics of 207 Lya Emitters at a Redshift Near 7: Constraints on Reionization and Galaxy Formation Models

We present Lya luminosity function (LF), clustering measurements, and Lya line profiles based on the largest sample, to date, of 207 Lya emitters (LAEs) at z=6.6 on the 1-deg^2 sky of Subaru/XMM-Newton Deep Survey (SXDS) field. Our z=6.6 Lya LF including cosmic variance estimates yields the best-fit Schechter parameters of phi*=8.5 +3.0/-2.2 x10^(-4) Mpc^(-3) and L*(Lya)=4.4 +/-0.6 x10^42 erg s^(-1) with a fixed alpha=-1.5, and indicates a decrease from z=5.7 at the >~90% confidence level. However, this decrease is not large, only =~30% in Lya luminosity, which is too small to be identified in the previous studies. A clustering signal of z=6.6 LAEs is detected for the first time. We obtain the correlation length of r_0=2-5 h^(-1) Mpc and bias of b=3-6, and find no significant boost of clustering amplitude by reionization at z=6.6. The average hosting dark halo mass inferred from clustering is 10^10-10^11 Mo, and duty cycle of LAE population is roughly ~1% albeit with large uncertainties. The average of our high-quality Keck/DEIMOS spectra shows an FWHM velocity width of 251 +/-16 km s^(-1). We find no large evolution of Lya line profile from z=5.7 to 6.6, and no anti-correlation between Lya luminosity and line width at z=6.6. The combination of various reionization models and our observational results about the LF, clustering, and line profile indicates that there would exist a small decrease of IGM's Lya transmission owing to reionization, but that the hydrogen IGM is not highly neutral at z=6.6. Our neutral-hydrogen fraction constraint implies that the major reionization process took place at z>~7.Comment: 28 pages, 23 figures. Accepted for publication in Ap

Large Area Survey for z=7 Galaxies in SDF and GOODS-N: Implications for Galaxy Formation and Cosmic Reionization

We present results of our large-area survey for z'-band dropout galaxies at z=7 in a 1568 arcmin^2 sky area covering the SDF and GOODS-N fields. Combining our ultra-deep Subaru/Suprime-Cam z'- and y-band (lambda_eff=1um) images with legacy data of Subaru and HST, we have identified 22 bright z-dropout galaxies down to y=26, one of which has a spectroscopic redshift of z=6.96 determined from Lya emission. The z=7 luminosity function (LF) yields the best-fit Schechter parameters of phi*=0.69 +2.62/-0.55 x10^(-3) Mpc^(-3), Muv*=-20.10 +/-0.76 mag, and alpha=-1.72 +/-0.65, and indicates a decrease from z=6 at a >95% confidence level. This decrease is beyond the cosmic variance in our two fields, which is estimated to be a factor of <~2. We have found that the cosmic star formation rate density drops from the peak at z=2-3 to z=7 roughly by a factor of ~10 but not larger than ~100. A comparison with the reionization models suggests either that the Universe could not be totally ionized by only galaxies at z=7, or more likely that properties of galaxies at z=7 are different from those at low redshifts having, e.g., a larger escape fraction (>~0.2), and/or a flatter IMF. Our SDF z-dropout galaxies appear to form 60-Mpc long filamentary structures, and the z=6.96 galaxy with Lya emission is located at the center of an overdense region consisting of four UV bright dropout candidates, which might suggest an existence of a well-developed ionized bubble at z=7.Comment: 20 pages; ApJ in press, measurements improved with HST/WFC3 data point

Lyman Alpha Emitters at z=7 in the Subaru/XMM-Newton Deep Survey Field: Photometric Candidates and Luminosity Function

We conducted a deep narrowband NB973 (FWHM = 200 A centered at 9755 A) survey of z=7 Lyman alpha emitters (LAEs) in the Subaru/XMM-Newton Deep Survey Field, using the fully depleted CCDs newly installed on the Subaru Telescope Suprime-Cam, which is twice more sensitive to z=7 Lyman alpha at ~ 1 micron than the previous CCDs. Reaching the depth 0.5 magnitude deeper than our previous survey in the Subaru Deep Field that led to the discovery of a z=6.96 LAE, we detected three probable z=7 LAE candidates. Even if all the candidates are real, the Lyman alpha luminosity function (LF) at z=7 shows a significant deficit from the LF at z=5.7 determined by previous surveys. The LAE number and Lyman alpha luminosity densities at z=7 is ~ 7.7-54% and ~5.5-39% of those at z=5.7 to the Lyman alpha line luminosity limit of L(Ly-alpha) >~ 9.2 x 10^{42} erg s^{-1}. This could be due to evolution of the LAE population at these epochs as a recent galaxy evolution model predicts that the LAE modestly evolves from z=5.7 to 7. However, even after correcting for this effect of galaxy evolution on the decrease in LAE number density, the z=7 Lyman alpha LF still shows a deficit from z=5.7 LF. This might reflect the attenuation of Lyman alpha emission by neutral hydrogen remaining at the epoch of reionization and suggests that reionization of the universe might not be complete yet at z=7. If we attribute the density deficit to reionization, the intergalactic medium (IGM) transmission for Lyman alpha photons at z=7 would be 0.4 <= T_{Ly-alpha}^{IGM} <= 1, supporting the possible higher neutral fraction at the earlier epochs at z > 6 suggested by the previous surveys of z=5.7-7 LAEs, z ~ 6 quasars and z > 6 gamma-ray bursts.Comment: Accepted to ApJ for publicatio

Design of a Middle Scale Wave Energy Convertor of a PW-OWC type for a Sea Test in Sakata Port

This study proposes a wave energy convertion (WEC) of an air turbine type with an oscillating water column (OWC) equipped with projecting walls (PW), which is called a PW-OWC type wave energy convertor in the study. OWC type WECs have been major and studied in Japan over 30 years. Because an electrical generation device is installed out of water but in air, maintenance would be easier than submerged type one and such like devices would be able to be installed on isting breakwaters and wave dissipating caissons. Thus cost of electrical generation might be saved. This study remodeled a ave dissipating double-caisson to a WEC of the PW-OWC type and conducted an ocean-wave-resistant design in order tocarry out a sea test of performances of power take-off (PTO), durability etc. Before that, basic performance of PTO was predicted from numerical model as well as well hydraulic experiments in a wave tank. This paper shows the feature of PTO of the model device using results of as the experiments conducted at the wave tank and b) the field monit0rinng of a prototype model on existing seawalls which are located in the Sakata port facing to the Sea of Japan. Observed data are presented on turbine torque and generated electricity as well as incident waves.The paper shows an intern report of the sea test.26?28 August 2015, Glasgow, U

FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

乳がんの再発を起こす原因細胞を解明. 京都大学プレスリリース. 2023-11-16.The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fuels phenotypic heterogeneity, we undertook single-cell transcriptomics analysis in triple-negative breast cancer (TNBC) to identify subpopulations in CSCs. We found a subpopulation of CSCs with ancestral features that is marked by FXYD domain–containing ion transport regulator 3 (FXYD3), a component of the Na⁺/K⁺ pump. Accordingly, FXYD3⁺ CSCs evolve and proliferate, while displaying traits of alveolar progenitors that are normally induced during pregnancy. Clinically, FXYD3⁺ CSCs were persistent during neoadjuvant chemotherapy, hence linking them to drug-tolerant persisters (DTPs) and identifying them as crucial therapeutic targets. Importantly, FXYD3⁺ CSCs were sensitive to senolytic Na⁺/K⁺ pump inhibitors, such as cardiac glycosides. Together, our data indicate that FXYD3⁺ CSCs with ancestral features are drivers of plasticity and chemoresistance in TNBC. Targeting the Na⁺/K⁺ pump could be an effective strategy to eliminate CSCs with ancestral and DTP features that could improve TNBC prognosis

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection