Relation between early life socioeconomic position and all cause mortality in two generations. A longitudinal study of Danish men born in 1953 and their parents

Objective: To examine (1) the relation between parental socioeconomic position and all cause mortality in two generations, (2) the relative importance of mother’s educational status and father’s occupational status on offspring mortality, and (3) the effect of factors in the family environment on these relations. Design: A longitudinal study with record linkage to the Civil Registration System. The data were analysed using Cox regression models. Setting: Copenhagen, Denmark. Subjects: 2890 men born in 1953, whose mothers were interviewed regarding family social background in 1968. The vital status of this population and their parents was ascertained from April 1968 to January 2002. Main outcome measures: All cause mortality in study participants, their mothers, and fathers. Results: A similar pattern of relations was found between parental social position and all cause mortality in adult life in the three triads of father, mother, and offspring constituted of the cohort of men born in 1953, their parents, and grandparents. The educational status of mothers showed no independent effect on total mortality when father’s occupational social class was included in the model in either of the triads. Low material wealth was the indicator that remained significantly associated with adult all cause mortality in a model also including parental social position and the intellectual climate of the family in 1968. In the men born in 1953 the influence of material wealth was strongest for deaths later in adult life. Conclusion: Father’s occupational social class is associated with adult mortality in all members of the mother-father-offspring triad. Material wealth seems to be an explanatory factor for this association

Mechanisms of interpersonal sway synchrony and stability

Here we explain the neural and mechanical mechanisms responsible for synchronizing sway and improving postural control during physical contact with another standing person. Postural control processes were modelled using an inverted pendulum under continuous feedback control. Interpersonal interactions were simulated either by coupling the sensory feedback loops or by physically coupling the pendulums with a damped spring. These simulations precisely recreated the timing and magnitude of sway interactions observed empirically. Effects of firmly grasping another person's shoulder were explained entirely by the mechanical linkage. This contrasted with light touch and/or visual contact, which were explained by a sensory weighting phenomenon; each person's estimate of upright was based on a weighted combination of veridical sensory feedback combined with a small contribution from their partner. Under these circumstances, the model predicted reductions in sway even without the need to distinguish between self and partner motion. Our findings explain the seemingly paradoxical observation that touching a swaying person can improve postural control.This work was supported by two BBSRC grants (BB/100579X/1 and an Industry Interchange Award)

Seismic stratigraphy and history of deep circulation and sediment drift development in Baffin Bay and the Labrador Sea

Drilling results and seismic-reflection records at and across Ocean Drilling Program (ODP) Sites 645 (western Baffin Bay), 646, and 647 (Labrador Sea) provide important constraints on the history of deep-water circulation and sedimentation in response to Cenozoic climatic change, as well as the tectonic evolution of the region. Sites 646 and 647 were drilled on the flanks of two sediment drift deposits—the Eirik Ridge and Gloria Drift, respectively. Age control at Site 645 was poor because of the restricted biotas there, but the drill site provides a continuous sequence from the lower Miocene to the present. Sediment at Site 646 was deposited at high rates, providing a high resolution record of the last 8.5 Ma. At Site 647 sedimentation was variable and discontinuous, but a complete upper-lower Eocene through lower Oligocene sequence was recovered, whereas the upper Oligocene to Holocene sequence was interrupted by several hiatuses. The drift sequence at Site 646 was constructed after the middle to early Pliocene (ca. 4.5 Ma). Before that time, evidence exists for variable bottom-current activity, with events at about 7.5 Ma (a change in water-mass characteristics and decreasing velocities) and 5.6 Ma (an increase in current velocity preceding the major 4.5-Ma event; R2 regional reflector). The 7.5-Ma event produced a major regional reflector (R3/R4), which was originally thought to be Eocene/ Oligocene in age. A major water-mass change also occurred at the onset of ice-rafting at about 2.5 Ma in the late Pliocene. In seismic records no evidence exists of drift building before the early Pliocene, but a probable late-middle Miocene erosional event occurred on the south flank of Eirik Ridge and along the West Greenland margin. Sediment supply from the Imarssuak mid-ocean canyon (IMOC) increased concurrently with the advent of drift construction. Gloria Drift also was built largely after the late Miocene. A major increase in sediment supply occurred in the early Pliocene, following a major hiatus (5.6 to 2.5 Ma; equivalent to the youngest possible age for the R2 reflector underlying Gloria Drift), and most seismic records exhibit sediment waves above this horizon. This increased sediment supply is the result of hemipelagic deposition from encroaching deposits of the North Atlantic mid-ocean canyon, as well as to supply of ice-rafted detritus in the late Pliocene. A hiatus encompasses the interval from approximately 17.5 to 8,2 Ma, and the interval between the two major hiatuses is extremely condensed. A deeper reflector (R3) corresponds to a change from calcareous (below) to opal-rich hemipelagic strata in the lower Oligocene, not to a regional unconformity reflecting increased bottom-water activity, as previously thought. However, some evidence exists to support a latest Eocene-earliest Oligocene increase in bottom-current activity on Gloria Drift. In Baffin Bay, there is evidence for bottom-water activity from textural studies of cores and from apparent drift features exhibited in multichannel lines along the western margin. Probable contour-currents have been active since at least the late middle Miocene, with episodes of decreasing intensity that apparently occurred in the late Miocene and Quaternary. The record from Site 645 and in seismic lines may indicate that formation of bottom water occurred in the late Neogene in Baffin Bay in conjunction with climatic deterioration, but Baffin Bay was not an important source of deep-water masses to the Labrador Sea after the late Pliocene. Not surprisingly, many of the Labrador Sea deep-circulation events correspond closely to major North Atlantic events and to important global climatic and paleoceanographic events, but a major drift-building episode may have occurred later in the Labrador Sea than it did in either the eastern North Atlantic or the western North Atlantic

Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature

Dermatomyositis is a clinically heterogenous inflammatory myopathy with unique cutaneous features. Myositis-specific antibodies can aid in diagnosis and anticipation of patient prognosis. Herein, we report a 22-year-old man who presented with multifocal erythematous plaques with violaceous papules on his bilateral elbows, neck, and face. He was diagnosed with biopsy-proven dermatomyositis and determined to be seropositive for nuclear matrix protein 2 antibody (NXP-2). He was treated with systemic corticosteroids, then intravenous methylprednisolone and azathioprine, and ultimately achieved greatest treatment response with intravenous immune globulin therapy

Does Educational Status Impact Adult Mortality in Denmark? A Twin Approach

To disentangle an independent effect of educational status on mortality risk from direct and indirect selection mechanisms, the authors used a discordant twin pair design, which allowed them to isolate the effect of education by means of adjustment for genetic and environmental confounding per design. The study is based on data from the Danish Twin Registry and Statistics Denmark. Using Cox regression, they estimated hazard ratios for mortality according to the highest attained education among 5,260 monozygotic and 11,088 dizygotic same-sex twin pairs born during 1921–1950 and followed during 1980–2008. Both standard cohort and intrapair analyses were conducted separately for zygosity, gender, and birth cohort. Educational differences in mortality were demonstrated in the standard cohort analyses but attenuated in the intrapair analyses in all subgroups but men born during 1921–1935, and no effect modification by zygosity was observed. Hence, the results are most compatible with an effect of early family environment in explaining the educational inequality in mortality. However, large educational differences were still reflected in mortality risk differences within twin pairs, thus supporting some degree of independent effect of education. In addition, the effect of education may be more pronounced in older cohorts of Danish men

Stationarity-conservation laws for certain linear fractional differential equations

The Leibniz rule for fractional Riemann-Liouville derivative is studied in algebra of functions defined by Laplace convolution. This algebra and the derived Leibniz rule are used in construction of explicit form of stationary-conserved currents for linear fractional differential equations. The examples of the fractional diffusion in 1+1 and the fractional diffusion in d+1 dimensions are discussed in detail. The results are generalized to the mixed fractional-differential and mixed sequential fractional-differential systems for which the stationarity-conservation laws are obtained. The derived currents are used in construction of stationary nonlocal charges.Comment: 28 page

Gallop Rhythm of the Heart:

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Turning points in a qualitatively different social space: young adults’ reflections of alternative provision

There is a wealth of evidence suggesting that after being marginalised and excluded from school young people who attend Alternative Provision settings report positive relationships and experiences of learning. There is however very little research which explores the longer term outcomes of attending this sort of provision. Retrospective life history interviews were undertaken with 18 young adults in their early to mid-20s who had attended Alternative Provision in England. Interviews focused on schooling, exclusion, attending Alternative Provision and the impact of this on what they had done since leaving school up to their present situation. Analysis showed that the experience of attending Alternative Provision frequently constituted a turning point in a young person’s life story. This was due to the qualitatively different kind of social space experienced there