143 research outputs found
A New Book about the Aksakov Clan and Family
The readers are invited to review the book by Andrey Petrovich Dmitriev βThe Aksakov Family: Literary Heritage and Civic Position: From Archival Research.β It is dedicated to the 200th anniversary of the birth of Ivan Sergeevich Aksakov, an outstanding Russian publicist of Slavophile trend, poet and public figure. The monograph explores various aspects of the life and activities of the representatives of the famous Aksakov family, who in their writings and correspondence actively responded to all the most important events in the cultural and social life of Russia. The research is based on extensive archival data, partly introduced into scientific circulation for the first time. In addition to covering a wide range of subjects the book provides a new approach to the accumulation of research potential in the study of the history of Russian clans and social processes in Russian society of the 19th century. The research is provided with illustrations, a list of abbreviations, an index of names and a valuable bibliographic references to the first publications of the materials placed or mentioned in the book
Preconditions for the development of Russian Arctic export, coastal (cabotage) transportation and project cargo for the arctic demand
The article considers the concept and description of the Northern Sea Route (NSR), the main prerequisites for the development of Russian Arctic export by using the NSR. The concept and analysis of coastal shipping using Arctic vessels and the predictive conclusions on possible Arctic projects are also presented in the article.
Systems for the development of Russian Arctic export, coastal transportation, and project cargo for Arctic demand include freight transport systems by rail and sea transport fleet. The purpose of this article is to analyze the data of transport systems, as well as to identify key prospects for the development of this system in Russia, taking into account a new concept β the Northern Sea Transport Corridor. According to the fact that it is a national transport corridor of the Russian Federation, the development of the cargo traffic is mainly connected with the Arctic exploration projects
ON THE ISSUE OF THE STUDY OF AUTOBIOGRAPHICAL MEMORY
ΓΒ ΓΒ Objective: The article focuses on the topical problem of the functioning of autobiographical memory, which is considered as a higher mental function. The aim of the research is to study autobiographical memory of people of different age groups using the method of free recall of events.Methods: The main parameters of the analysis are as follows: Memories peak,Γ’β¬ subjective importance of the events and dynamics of autobiographical memory.Results: The research results suggest that positive experiences dominate in the structure of autobiographical memory. This may indicate psychological protective mechanisms of a person. The dynamics of autobiographical memory is observed in all age groups. This results in changing the evaluation of events. This can be explained by a change in personality, the transformation of values, interests and moral principles of a person.Conclusion: The study revealed that subjects of all age groups primarily remember old events and, last of all, the events of the recent past
CaCu2(SeO3)2Cl2: spin-1/2 Heisenberg chain compound with complex frustrated interchain couplings
We report the crystal structure, magnetization measurements, and
band-structure calculations for the spin-1/2 quantum magnet CaCu2(SeO3)2Cl2.
The magnetic behavior of this compound is well reproduced by a uniform spin-1/2
chain model with the nearest-neighbor exchange of about 133 K. Due to the
peculiar crystal structure, spin chains run in the direction almost
perpendicular to the structural chains. We find an exotic regime of frustrated
interchain couplings owing to two inequivalent exchanges of 10 K each. Peculiar
superexchange paths grant an opportunity to investigate bond-randomness effects
under partial Cl-Br substitution.Comment: Extended version: 9 pages, 7 figures, 4 table
Public Health Risk Conditioned by Chemical Composition of Ground Water
The article studies the public health potential risk originated from water consumption and estimated on the basis of the groundwater chemical composition. We have processed the results of chemical groundwater analysis in different aquifers of Tomsk district (Tomsk Oblast, Russia). More than 8400 samples of chemical groundwater analyses were taken during long-term observation period. Human health risk assessment of exposure to contaminants in drinking water was performed in accordance with the risk assessment guidance for public health concerning chemical pollution of the environment (Russian reference number: 2.1.10.1920-04-M, 2004). Identified potential risks were estimated for consuming water of each aquifer. The comparative analysis of water quality of different aquifers was performed on the basis of the risk coefficient of the total non-carcinogenic effects. The non-carcinogenic risk for the health of the Tomsk district population due to groundwater consumption without prior sanitary treatment was admitted acceptable. A rather similar picture is observed for all aquifers, although deeper aquifers show lower hazard coefficients
Public Health Risk Conditioned by Chemical Composition of Ground Water
The article studies the public health potential risk originated from water consumption and estimated on the basis of the groundwater chemical composition. We have processed the results of chemical groundwater analysis in different aquifers of Tomsk district (Tomsk Oblast, Russia). More than 8400 samples of chemical groundwater analyses were taken during long-term observation period. Human health risk assessment of exposure to contaminants in drinking water was performed in accordance with the risk assessment guidance for public health concerning chemical pollution of the environment (Russian reference number: 2.1.10.1920-04-M, 2004). Identified potential risks were estimated for consuming water of each aquifer. The comparative analysis of water quality of different aquifers was performed on the basis of the risk coefficient of the total non-carcinogenic effects. The non-carcinogenic risk for the health of the Tomsk district population due to groundwater consumption without prior sanitary treatment was admitted acceptable. A rather similar picture is observed for all aquifers, although deeper aquifers show lower hazard coefficients
Informational characteristics of microbial biofilms formed by clinical strains of Klebsiella pneumoniae in vitro on the surface of the cover glass
Purpose Obtaining quantitative and informational characteristics of biofilms formed by clinical strains of Klebsiella pneumoniae in vitro on the surface
of a cover glass. Materials and methods In vitro biofilm formation on the surface of the cover glass was studied for clinical Klebsiella pneumoniae
strains, isolated in a monoculture (ESBL +) (n = 3) and in associations with Staphylococcus aureus (n = 6) in 9 patients with chronic osteomyelitis
of long bones harvrested from fistulae in the preoperative period or from the infection focus during surgery. Results Monocultures of K. pneumoniae
(BLRS +) differed by their lower adhesive ability when compared to strains of K. pneumoniae isolated from associations with S. aureus. The highest
adhesive activity on the surface of the cover glass was observed in a mixed culture of K. pneumoniae + S. aureus. Informational characteristics depended
on the type of biofilms formed. Common to biofilms was the absence of changes in the maximum possible structural diversity. Significant differences
between the existing structural diversity of biofilms formed by monocultures of K. pneumonia, K. pneumonia isolated from associations and a mixed
culture of K. pneumoniae + S. aureus were noted. Conclusion The absence of pronounced variability of information indicators during the experiment
within each microbial community indicates the tendecy of all systems of emerging biofilms to preserve stabilit
The effectiveness of using lipid- and water-soluble analogues of vitamin E as antioxidant protectors for cryopreservation of sperm of sterlet (Acipenser ruthenus) and Russian sturgeon (Acipenser gueldenstaedtii)
The aim of the research was to comparative study the effectiveness of synthetic antioxidants β lipid-soluble (butylated hydroxytoluene, BHT) and waterβsoluble (trolox) analogues of vitamin E for the cryopreservation of Russian sturgeon and sterlet sperm in the presence of the modified Steinβs medium. The ability of phenolic antioxidants to reduce the level of lipid peroxidation of sturgeon sperm, beneficial effect on the motility of thawed sperm has been shown. The addition of lipid- and water-soluble antioxidants to a basic cryomedim increased the fertilization rate of Russian sturgeon and sterlet sperm cells about 10% compared to the control experiment. The insignificant protective effect of these antioxidants presumably is explained by the use of a cryogenic medium with additive of toxic DMSO, therefore, it is necessary to develop a new composition of the cryo-medium with a minimum concentration of DMSO
ΠΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΡΡΠΌΠ° ΠΈ COVID-19: ΠΎΠ±Π·ΠΎΡ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΠΏΠΎ Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π±ΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ Π²ΠΎ Π²ΡΠ΅ΠΌΡ ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠΈ COVID-19
The emergence of a new disease COVID-19 (coronavirus disease 2019), caused by the coronavirus named SARS-CoV-2, has significantly changed the usual interaction pattern between a doctor and a patient. Previous large studies have identified risk factors for a severe course of COVID-19, including old age, hypertension, diabetes, cardiovascular diseases, and chronic obstructive pulmonary disease. However, asthma and respiratory allergy have not been identified as risk factors for the severe disease. These factors give clues to the pathogenesis of COVID-19, approaches to the controller medications, target therapy, allergen-specific immunotherapy (ASIT) in patients with various phenotypes and endotypes of asthma during the pandemic.The purpose of this review is to summarize the currently available knowledge about SARS-CoV-2, T2-endotype of asthma, eosinophilic inflammation. The article provides an overview of the data from studies of COVID-19 patients with asthma, the main recommendations of the Global Initiative for Asthma (2021) and the Ministry of Health of the Russian Federation. It shows that targeting the endotypes and phenotypes of asthma can influence the management of COVID-19 patients with asthma. The influence of the imbalance of the immune system, pro-inflammatory cytokines, and effector cells in patients with asthma on the development and progression of COVID-19 is considered. Recommendations are given for the controller medications, targeted therapy, allergen-specific immunotherapy during the pandemic.Conclusion. The current recommendations for asthma treatment, based on the latest research of COVID-19, deepen our understanding of the course of COVID-19 in patients with different phenotypes and endotypes of asthma, approaches to traditional methods of treating asthma according to clinical guidelines during the pandemic.ΠΡΠΈ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠΈ Π½ΠΎΠ²ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ COVID-19 (COronaVIrus Diseaseβ2019), Π²ΡΠ·Π²Π°Π½Π½ΠΎΠ³ΠΎ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠΎΠΌ SARS-CoV-2, Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΈΠ·ΠΌΠ΅Π½ΠΈΠ»Π°ΡΡ ΠΏΡΠΈΠ²ΡΡΠ½Π°Ρ ΡΡ
Π΅ΠΌΠ° Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π²ΡΠ°ΡΠ° ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°. ΠΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΊΡΡΠΏΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π²ΡΡΠ²Π»Π΅Π½ ΡΡΠ΄ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ COVID-19 β ΠΏΠΎΠΆΠΈΠ»ΠΎΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ, Π³ΠΈΠΏΠ΅ΡΡΠΎΠ½ΠΈΡ, ΡΠ°Ρ
Π°ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρ, ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½Ρ Π±ΠΎΠ»Π΅Π·Π½Ρ Π»Π΅Π³ΠΊΠΈΡ
. ΠΠ΄Π½Π°ΠΊΠΎ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΡΡΠΌΠ° (ΠΠ) ΠΈ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½Π°Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡ Π½Π΅ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΊΠ°ΠΊ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ ΡΠΈΡΠΊΠ° ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π° Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π΄Π°Π΅Ρ Π²Π°ΠΆΠ½ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ COVID-19, ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°Ρ
ΠΊ Π±Π°Π·ΠΈΡΠ½ΠΎΠΉ, ΡΠ°ΡΠ³Π΅ΡΠ½ΠΎΠΉ ΠΈ Π°Π»Π»Π΅ΡΠ³Π΅Π½-ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (ΠΠ‘ΠΠ’) Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠΈ ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ΅Π½ΠΎΡΠΈΠΏΠ°Ρ
ΠΈ ΡΠ½Π΄ΠΎΡΠΈΠΏΠ°Ρ
ΠΠ.Π¦Π΅Π»ΡΡ ΠΎΠ±Π·ΠΎΡΠ° ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΡ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π·Π½Π°Π½ΠΈΠΉ ΠΎ SARSβCoVβ2, Π’2-ΡΠ½Π΄ΠΎΡΠΈΠΏΠ΅ ΠΠ, ΡΠΎΠ·ΠΈΠ½ΠΎΡΠΈΠ»ΡΠ½ΠΎΠΌ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠΈ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠ΅ΡΠ΅Π½ΠΈΡ COVID-19 Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ, ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΠ»ΠΎΠ±Π°Π»ΡΠ½ΠΎΠΈΜ ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΈΠ²Ρ ΠΏΠΎ ΠΠ (Global Initiative for Asthma β GINA, 2021) ΠΈ ΠΠΈΠ½ΠΈΡΡΠ΅ΡΡΡΠ²Π° Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π° ΡΠ½Π΄ΠΎΡΠΈΠΏΡ ΠΈ ΡΠ΅Π½ΠΎΡΠΈΠΏΡ ΠΠ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π²ΡΠ±ΠΎΡΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ COVID-19 ΠΈ ΠΠ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π΄ΠΈΡΠ±Π°Π»Π°Π½ΡΠ° ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, ΠΏΡΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ², ΡΡΡΠ΅ΠΊΡΠΎΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ Π½Π° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ COVID-19. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ Π±Π°Π·ΠΈΡΠ½ΠΎΠΉ, ΡΠ°ΡΠ³Π΅ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ, ΠΠ‘ΠΠ’ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠΈ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π’Π΅ΠΊΡΡΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΠ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°Ρ
ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π² ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΠ΅ c COVID-19 ΡΠ³Π»ΡΠ±Π»ΡΡΡ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΊΠΎΠΎΡΠ½ΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΡΠ΅Π½ΠΎΡΠΈΠΏΠ°ΠΌΠΈ ΠΈ ΡΠ½Π΄ΠΎΡΠΈΠΏΠ°ΠΌΠΈ ΠΠ ΠΈ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌ Π΅Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΡΠΌ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠΈ
Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain Aging
Blood-brain barrier (BBB) modeling in vitro is a huge area of research covering study of intercellular communications and development of BBB, establishment of specific properties that provide controlled permeability of the barrier. Current approaches in designing new BBB models include development of new (bio) scaffolds supporting barriergenesis/angiogenesis and BBB integrity; use of methods enabling modulation of BBB permeability; application of modern analytical techniques for screening the transfer of metabolites, bio-macromolecules, selected drug candidates and drug delivery systems; establishment of 3D models; application of microfluidic technologies; reconstruction of microphysiological systems with the barrier constituents. Acceptance of idea that BBB in vitro models should resemble real functional activity of the barrier in different periods of ontogenesis and in different (patho) physiological conditions leads to proposal that establishment of BBB in vitro model with alterations specific for aging brain is one of current challenges in neurosciences and bioengineering. Vascular dysfunction in the aging brain often associates with leaky BBB, alterations in perivascular microenvironment, neuroinflammation, perturbed neuronal and astroglial activity within the neurovascular unit, impairments in neurogenic niches where microvascular scaffold plays a key regulatory role. The review article is focused on aging-related alterations in BBB and current approaches to development of βagingβ BBB models in vitro
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