PROGRAM MODULE FOR EVALUATION OF STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE HEART IN CHILDREN OF THE FIRST YEAR OF LIFE

The developed software module is designed to assess the structural and functional param-eters of the heart in children of the first year of life and automatically correlate the values measured during echocardiography with the normal criteria

THE CREATION OF THE DESIGN OF THE TRIPOD FOR POSITIONING A SURGICAL MICROSCOPE WHILE PERFORMING ATHEROGENIC INTERVENTIONS

An important parameter when using surgical microscopes in otosurgery is its installation using the specific technical solution. The design of the tripod structure for mounting and po-sitioning the surgical microscope when performing surgical interventions on an auditory an-alyzer was carried out

THE APPLICATION OF MATHEMATICAL MODELING METHODS IN THE EVALUATION THE RISK OF AN INCREASED INTRAOCULAR PRESSURE AFTER LASER VISION CORRECTION

One of the important biophysical tasks is predicting the risk of developing glaucoma in patients undergoing laser vision correction for myopia. A mathematical model has been created for individual prediction of the risk of increased intraocular pressure using regression analysis

CHANGE OF PHYSICAL PARAMETERS OF GEOSYNTHETIC MATERIAL UNDER THE ACTION OF CHEMICAL MEDIA

The polymer material was tested for resistance to chemical media, which were selected as: hydrochloric acid, acetic acid, sodium chloride solution, sodium hydroxide solution. After extraction from the test fluid and drying, to change in mass, size, and appearance of the samples was determined

Macrophage activation syndrome in COVID-19

The novel coronavirus epidemic is characterized by high rates of morbidity and relatively high mortality. Laboratory test results in patients include leukopenia, an increase in liver function tests and ferritin levels reaching hundreds, and sometimes thousands of units. These data remind us about the macrophage activation syndrome (MAC). Secondary hemophagocytic lymphohistiocytosis syndrome, MAC, which pathogenesis is based on a defect in the mechanisms of T-cell cytotoxicity and decreased level of natural killer cells associated with the defect in the perforin-encoding gene as well as hyperproduction of a number of cytokines – interleukin (IL)-1â, tumor necrosis factor-á, etc. by T-lymphocytes and histiocytes, indirectly leading to the activation of macrophages and production of proinflammatory cytokines, in particular IL-6 hyperproduction. MAC is one of "hyperferritinemic syndromes". These disorders have similar clinical and laboratory manifestations, and they also respond to similar treatments, suggesting that hyperferritinemia may be involved in the overall pathogenesis and is characterized by elevated ferritin level and cytokine storm. Despite the fact that data on the immune and inflammatory status in patients with COVID-19 have only started to appear, it is already clear that hyperinflammation and coagulopathy affect the disease severity and increase the risk of death in patients infected with SARS-CoV-2. Hence, understanding the pathogenesis of the novel coronavirus infection can help in its early diagnostics and treatment