[Review of] Silvester Brito. Red Cedar Warrior

Red Cedar Warrior, the collection of poems by S.J. Brito, is very obvious in its depiction of trepidations against Native Americans, in its mourning for the loss of culture and traditions, and its expression of anger. We easily see the obvious signs of Native Americanism in most of the poems included in his book. The warrior could not be anything other than Native American, astride a pony, feathered and painted. There are the drums, the ceremonial life, the peyote prayers, the shamans, and such references. We easily see the images and hear the voices that most let us know of the poet\u27s intent to share with us a Native American viewpoint. And why not? After all, Brito is a proud descendant of Comanches and Tarascans

A three-dimensional multiscale model of intergranular hydrogen-assisted cracking

We present a three-dimensional model of intergranular hydrogen-embrittlement (HE) that accounts for: (i) the degradation of grain-boundary strength that arises from hydrogen coverage; (ii) grain-boundary diffusion of hydrogen; and (iii) a continuum model of plastic deformation that explicitly resolves the three-dimensional polycrystalline structure of the material. The polycrystalline structure of the specimen along the crack propagation path is resolved explicitly by the computational mesh. The texture of the polycrystal is assumed to be random and the grains are elastically anisotropic and deform plastically by crystallographic slip. We use the impurity-dependent cohesive model in order to account for the embrittling of grain boundaries due to hydrogen coverage. We have carried out three-dimensional finite-element calculations of crack-growth initiation and propagation in AISI 4340 steel double-cantilever specimens in contact with an aggressive environment and compared the predicted initiation times and crack-growth curves with the experimental data. The calculated crack-growth curves exhibit a number of qualitative features that are in keeping with observation, including: an incubation time followed by a well-defined crack-growth initiation transition for sufficiently large loading; the existence of a threshold intensity factor K_(Iscc) below which there is no crack propagation; a subsequent steeply rising part of the curve known as stage I; a plateau, or stage II, characterized by a load-insensitive crack-growth rate; and a limiting stress-intensity factor K_(Ic), or toughness, at which pure mechanical failure occurs. The calculated dependence of the crack-growth initiation time on applied stress-intensity factor exhibits power-law behavior and the corresponding characteristic exponents are in the ball-park of experimental observation. The stage-II calculated crack-growth rates are in good overall agreement with experimental measurements

CONTRASTING EFFECTS OF AN MDM2 FUNCTIONAL POLYMORPHISM ON TUMOR PHENOTYPES

Cancer predisposition by the cooperation of genetic variants, such as single nucleotide polymorphisms (SNPs), may be of much greater significance to public health than previously appreciated. Functional polymorphisms are genetic variants that alter gene function. Meta-analyses associate many functional polymorphisms with cancer risk. The MDM2 SNP309G allele is a cancer-associated functional polymorphism positioned in the MDM2 P2 promoter that enhances transcription factor SP1 binding, resulting in elevated levels of MDM2 concomitant with decreased p53 tumor-suppressor activity. Mdm2SNP309G/G mice are more prone to spontaneous tumor formation than Mdm2SNP309T/T mice, providing direct evidence for the impact of this SNP on tumor development. We examined the impact of SNP309 on cancer risk in response to environmental factors by treating SNP309 mice with ionizing radiation, UVB, or Benzo(a)pyrene. The results show that SNP309G cooperates with ionizing radiation to exacerbate tumor development. Contrastingly, ultraviolet B light or Benzo(a)pyrene exposure of skin indicates that SNP309G allele protects against squamous cell carcinoma susceptibility. These contradicting differences led us to interrogate the mechanism by which Mdm2 SNP309 regulates tumor susceptibility in a tissue-specific manner. The assessment of potential transcriptional regulators in ENCODE ChIP-seq database identified transcriptional repressor E2F6 as a possible negative regulator of MDM2 expression. Our data show that E2F6 protein is expressed at higher levels in skin keratinocytes of SNP309 mice as compared to lymphatic tissues. Furthermore, E2F6 binds and suppresses Mdm2 expression in cells harboring the SNP309G allele but not the SNP309T allele. Thus, the Mdm2 SNP309G allele exhibits tissue-specific regulation and differentially impacts cancer risk

Splitting formulas for certain Waldhausen Nil-groups

For a group G that splits as an amalgamation of A and B over a common subgroup C, there is an associated Waldhausen Nil-group, measuring the "failure" of Mayer-Vietoris for algebraic K-theory. Assume that (1) the amalgamation is acylindrical, and (2) the groups A,B,G satisfy the Farrell-Jones isomorphism conjecture. Then we show that the Waldhausen Nil-group splits as a direct sum of Nil-groups associated to certain (explicitly describable) infinite virtually cyclic subgroups of G. We note that a special case of an acylindrical amalgamation includes any amalgamation over a finite group C.Comment: 12 page