E-GOVERNMENT AS A BASIC FOR ECONOMIC DEVELOPMENT IN UKRAINE

Development of information society in Ukraine and introduction of new information and communication technologies in areas of social life and activity of the government is defined by effective work of the e-government in the country. The article is devoted to finding the role of e-government in the socio-economic development. The aim of of this paper is to find the the main directions of e-government in the information society to improve the efficiency of government in Ukraine and the access to international information society. The article is analyzed the factors constraining introduction of electronic government in Ukraine, obstacles for users of e-governments system in the conditions of information society  also. It is proved that e-government is the foundation of a new model of governance in Ukraine. The article is analysed a rating of the European countries (separately Eastern Europe) by efficiency of introduction of the electronic government. The methodological basis of  research is made by a logical and dialectic method of knowledge of economic events and state regulation machineries in modern world and national economies, the provision of fundamental works on the economic theory, international law and public administration

Ground-state multiquantum vortices in rotating two-species superfluids

We show numerically that a rotating, harmonically trapped mixture of two Bose-Einstein-condensed superfluids can, contrary to its single-species counterpart, contain a multiply quantized vortex in the ground state of the system. This giant vortex can occur without any accompanying single-quantum vortices, may either be coreless or have an empty core, and can be realized in a $^{87}$Rb-$^{41}$K Bose-Einstein condensate. Our results not only provide a rare example of a stable, solitary multiquantum vortex but also reveal exotic physics stemming from the coexistence of multiple, compositionally distinct condensates in one system.Comment: 6 pages, 4 color figures; identical in content to the published articl

Skyrmionic vortex lattices in coherently coupled three-component Bose-Einstein condensates

We show numerically that a harmonically trapped and coherently Rabi-coupled three-component Bose-Einstein condensate can host unconventional vortex lattices in its rotating ground state. The discovered lattices incorporate square and zig-zag patterns, vortex dimers and chains, and doubly quantized vortices, and they can be quantitatively classified in terms of a skyrmionic topological index, which takes into account the multicomponent nature of the system. The exotic ground-state lattices arise due to the intricate interplay of the repulsive density-density interactions and the Rabi couplings as well as the ubiquitous phase frustration between the components. In the frustrated state, domain walls in the relative phases can persist between some components even at strong Rabi coupling, while vanishing between others. Consequently, in this limit the three-component condensate effectively approaches a two-component condensate with only density-density interactions. At intermediate Rabi coupling strengths, however, we face unique vortex physics that occurs neither in the two-component counterpart nor in the purely density-density-coupled three-component system.Comment: 13 pages, 16 color figures; v2 is identical in content to the published articl

Ruslands økonomi under sanktioner

Udenrigs har interviewet forskningschef ved den russiske Alfa-Bank om betydningen af Vestens sanktioner for russisk økonomi.&nbsp

Structural and Biochemical Studies of the DNA Replication Initiation Mechanism of the Second Chromosome of \u3ci\u3eVibrio cholerae\u3c/i\u3e

Transmission of genetic information through DNA replication is one of the key processes for any living organism. Despite the extensive effort put into studies of the mechanism of DNA replication, the understanding of the process on the molecular level is still incomplete. Specifically the molecular details of the very first events of DNA replication initiation are not sufficiently understood. The majority of bacteria possess a single circular chromosome, and in order to initiate DNA replication these organisms utilize a conserved system, consisting of a specific DNA sequence - replication origin, called oriC, and replication initiator protein DnaA. However, bacteria with multipartite genomes evolved distinct systems to initiate replication of secondary chromosomes. In Vibrio cholerae, and in related species, secondary chromosome replication requires specific origin of replication, OriCII, and unique initiator protein, RctB, which shares no sequence similarity with other initiator proteins. Previous structural studies of bacterial DNA replication initiation were conducted in two kinds of systems: bacterial primary chromosomes and bacterial plasmids; these studies have been challenging, and there are still many opened questions to date. No prior structural work was done in order to elucidate mechanism of DNA replication initiation in secondary bacterial chromosomes, such as DNA replication initiation conducted by RctB-oriCII system. The work described in this dissertation is dedicated to structural studies of RctB-oriCII system. The structures of all four RctB domains were solved using X-ray crystallography and biophysical and biochemical analyses of RctB-DNA complexes were conducted. This work produced first structural view for the secondary chromosomal DNA replication initiation machinery and laid out a strong foundation for future structural studies of RctB-OriCII complexes. We demonstrate that RctB consists of four domains. The structure of its central two domains resembles that of several plasmid replication initiators. RctB contains at least three DNA binding winged helix turn helix motifs, and mutations within any of these severely compromise biological activity. In the structure, RctB adopts a head-to-head dimeric configuration that likely reflects the arrangement in solution. Therefore, major structural reorganization must accompany complex formation on the head-to-tail array of binding sites in oriCII. These findings support the hypothesis that the second Vibrionaceae chromosome arose from an ancestral plasmid, and that RctB may have evolved additional regulatory features. The structural and biophysical data obtained in the course of this work allowed us to develop a model of the macromolecular complex that several molecules of RctB form on replication origin of the secondary Vibrio cholerae chromosome

How Important Is Asset Allocation To Americans’ Financial Retirement Security?

Financial advice tends to focus on financial assets, but other levers may be more important for most households. This chapter proceeds in three stages. First we report a simple Excel spreadsheet exercise that provides a stylized example of the tradeoff between returns and time spent in the labor force. Next we use data from the Health and Retirement Study (HRS) on pre-retirees age 51-64 to see how the gap between retirement needs and retirement resources is affected by working longer, taking out a reverse mortgage, controlling spending, and shifting all assets to equities with no risk. Last we use a simple dynamic programming model to calculate a risk-adjusted measure of the value for the average household of moving from a typical conservative portfolio to an optimal portfolio. Our answer from all three exercises suggests that the focus on asset allocation is misplaced

The impact of European law on the development of legal system of Russia

The aim of the article is to identify the nature of the influence of European law on Russian legal system, carried out in the framework of the impact on the Russian legislation, the Russian Federation's participation in the European legal processes and the traditional reception of the positive European experience in the field of law. Package and systemic approaches are used as the methodological basis of research to the analysis of the legal problems associated with the international obligations resulting from the need to implement the European legal standards into the Russian legal system. In the article the thesis is substantiated according to which the influence of European law on the legal system of Russia is the Europeanization of the Russian legal culture in general, as well as in the modernization of legislation on the basis of European standards and the Europeanisation of the Russian judicial practice.peer-reviewe

FEATURES OF THE DEVELOPMENT OF A LYOPHILIZED INJECTABLE DOSAGE FORM OF THE ORIGINAL ANTICANCER DRUG LCS-1208

Objective: Development of a lyophilized injectable dosage form LCS-1208, an original antitumor drug based on an indolocarbazole derivative. Methods: The prepared solution of the injectable dosage form LCS-1208 is transferred to sterilizing filtration, which is carried out under vacuum on a «Stericup» filter unit with a filter pore size of 0.22 μm. The sterile solution of the injectable dosage form LCS-1208 is poured into sterile vials using a dispenser and lyophilized in a freeze-drying chamber. At the end of drying, the preparation is corked in the chamber of a sublimation unit using a hydraulic device and transferred to crimping with aluminum caps using a seaming machine. Quantitative determination of the drug content was determined by spectrophotometry using a standard sample at λ = 320±2 nm. The pH was determined by potentiometry. Results: A freeze-drying regimen for the injectable dosage form LCS-1208 has been developed. The required solution freezing temperature was established taking into account the presence of 2 eutectic zones: a solution of LCS-1208 in DMSO (-35 ÷-32) °С, an aqueous solution of Kollidon 17PF (-10 ÷-8) °С. As a result of a series of experiments, the optimal lyophilization regime was chosen that does not require preliminary freezing in a low-temperature chamber, with freezing on the shelves of freeze-drying at a temperature of-47 °C without their preliminary cooling. The most acceptable vial filling volume was determined, amounting to 3 ml, and the rate of temperature rise during secondary drying of the preparation was justified. When using the developed regime of lyophilization of the LCS-1208 solution, it was shown that it can be sublimated while preserving the initial qualitative and quantitative characteristics. Conclusion: In this article, using the example of creating a lyophilized injectable dosage form LCS-1208 (the original antitumor drug from the indolocarbazole group), the main problems that arose during the lyophilization of the selected composition of the model solution, as well as ways to improve the process