The CERN Cryogenic Test Facility for the Atlas Barrel Toroid Magnets

The superconducting magnet system of the ATLAS detector will consist of a central solenoid, two end-cap toroidal magnets (ECT) and the barrel toroid magnet (BT) made of eight coils symmetrically placed around the central axis of the detector. The magnets will be tested individually in a 5000 m2 experimental area prior to their final installation at an underground cavern of the LHC Collider. For the BT magnets, a dedicated cryogenic test facility has been designed which is currently under the construction and commissioning phase. A liquid nitrogen pre-cooling unit and a 1200 [email protected] refrigerator will allow flexible operating conditions via a rather complex distribution and transfer line system. Flow of two-phase helium for cooling the coils is provided by centrifugal pumps immersed in a saturated liquid helium bath. The integration of the pumps in an existing cryostat required the adoption of novel mechanical solutions. Tests conducted permitted the validation of the technical design of the cryostat and its instrumentation. The characteristics of one pump were measured and pressure rise of 300 mbar at nominal flow of 80 g/s confirmed the specifications

Guidelines for the functional annotation of microRNAs using the Gene Ontology

MicroRNA regulation of developmental and cellular processes is a relatively new field of study, and the available research data have not been organized to enable its inclusion in pathway and network analysis tools. The association of gene products with terms from the Gene Ontology is an effective method to analyze functional data, but until recently there has been no substantial effort dedicated to applying Gene Ontology terms to microRNAs. Consequently, when performing functional analysis of microRNA data sets, researchers have had to rely instead on the functional annotations associated with the genes encoding microRNA targets. In consultation with experts in the field of microRNA research, we have created comprehensive recommendations for the Gene Ontology curation of microRNAs. This curation manual will enable provision of a high-quality, reliable set of functional annotations for the advancement of microRNA research. Here we describe the key aspects of the work, including development of the Gene Ontology to represent this data, standards for describing the data, and guidelines to support curators making these annotations. The full microRNA curation guidelines are available on the GO Consortium wiki (http://wiki.geneontology.org/index.php/MicroRNA_GO_annotation_manual)

Artificial Intelligence for Sustainable Development: Synthesis Report, Mobile Learning Week 2019

(First paragraph) 2019’s Mobile Learning Week (MLW), UNESCO’s flagship event for information and communication technology (ICT) in education, focused on the theme ‘Artificial Intelligence for Sustainable Development’. Held over five days in Paris, it comprised a sequence of high-profile events (a global conference, a policy forum and workshops, a symposium and strategy labs), and involved more than 1,500 participants from 140 countries (including Ministers of Education and ICT, other representatives from Member States, the private sector, academia and international organizations)

Guidelines for the functional annotation of microRNAs using the Gene Ontology.

MicroRNA regulation of developmental and cellular processes is a relatively new field of study, and the available research data have not been organized to enable its inclusion in pathway and network analysis tools. The association of gene products with terms from the Gene Ontology is an effective method to analyze functional data, but until recently there has been no substantial effort dedicated to applying Gene Ontology terms to microRNAs. Consequently, when performing functional analysis of microRNA data sets, researchers have had to rely instead on the functional annotations associated with the genes encoding microRNA targets. In consultation with experts in the field of microRNA research, we have created comprehensive recommendations for the Gene Ontology curation of microRNAs. This curation manual will enable provision of a high-quality, reliable set of functional annotations for the advancement of microRNA research. Here we describe the key aspects of the work, including development of the Gene Ontology to represent this data, standards for describing the data, and guidelines to support curators making these annotations. The full microRNA curation guidelines are available on the GO Consortium wiki (http://wiki.geneontology.org/index.php/MicroRNA_GO_annotation_manual).R.P.H. and R.C.L are supported by funding from a British Heart Foundation grant (RG/13/5/30112) and the National Institute for Health Research University College London Hospitals Biomedical Research Centre. M.M. is a Senior Research Fellow of the British Heart Foundation (FS/13/2/29892). A.Z. is an Intermediate Fellow of the British Heart Foundation (FS/13/18/30207). D.S. is supported by a grant awarded to the Mouse Genome Database from the National Human Genome Research Institue at the US National Institutes of Health (HG-00330). P.D’E., M.G., M.O-M. are supported by grants from the US National Institutes of Health (P41 HG003751 and U54 GM114833), Ontario Research Fund, and the European Molecular Biology Laboratory. D.H. is supported by a grant awarded to the Zebrafish Information Network fromthe National Human Genome Research Institute at the US National Institutes of Health (HG002659). A.Z.K. is funded by a NIHR University College London Hospitals Biomedical Research Centre, Research Capability Funding award (RCF) (RCF123). L.M. is a Ragnar Söderberg fellow in Medicine (M-14/55), and received funding from Swedish Heart-Lung-Foundation (20120615, 20130664, 20140186). Huntley, RP 22 R.B. and D.O-S. are supported by R.B. and D.O-S. are supported by a grant awarded to The Gene Ontology Consortium (Principal Investigators: JA Blake, JM Cherry, S Lewis, PW Sternberg and P Thomas) by the National Human Genome Research Institute (NHGRI) (#U41 HG22073). V.P. and J.R.S. are supported by a grant from the National Heart, Lung, and Blood Institute on behalf of the National Institutes of Health (HL64541). K.V.A. is supported by a grant awarded to the Gene Ontology Consortium from the National Human Genome Research Institute at the US National Institutes of Health (HG002273). V.W. is supported by a Wellcome Trust grant (104967/Z/14/Z). We would like to thank Leonore Reiser and Tanya Berardini who provided guidance on the plant miRNA processing pathway. Also thanks to David Hill, Harold Drabkin, Judith Blake, Karen Christie, Donghui Li and Pascale Gaudet who contributed to discussions regarding GO curation procedures and to Lisa Matthews and Bruce May who provided helpful feedback on the manuscript. We are very grateful to Tony Sawford and Maria Martin from the European Bioinformatics Institute for access to the online GO curation tool, which is an essential component of this annotation project. Many thanks to members of the GO Editorial Office for useful discussions about the placement and definition of new GO terms. We also thank Alex Bateman and Anton Petrov for being responsive to our feedback regarding RNAcentral functionality. Author contributions: R.C.L. initiated discussions in the GO Consortium regarding miRNA curation guidelines and supervised the project, R.P.H. researched and constructed the guidelines and wrote the manuscript, R.P.H., R.C.L., D.S., R.B., P.D’E., M.G., M.O-M., D.H., V.P., J.R.S., K.V.A. and V.W. contributed to discussions regarding GO curation procedures and provided feedback on the manuscript. D.O-S. provided the expertise on definitions and placements of miRNA-related GO terms and performed the necessary updates and additions to both the GO and to the annotation extension relations used herein. M.M., A.Z., L.M. and A.Z.K. provided guidance with the scientific aspect of the guidelines and provided feedback on the manuscript.This is the final version of the article. It first appeared from Cold Spring Harbor Press via http://dx.doi.org/10.1261/rna.055301.11

Survival of massive allografts in segmental oncological bone defect reconstructions

Reconstructions of large segmental bone defects after resection of bone tumours with massive structural allografts have a high number of reported complications including fracture, infection and non-union. Our goal is to report the survival and complications of massive allografts in our patients. A total of 32 patients were evaluated for fracture, infection, non-union rate and survival of their massive allograft reconstructions. The average follow-up for this group was five years and three months. The total fracture rate was 13% with a total infection rate of 16%. We found a low union rate of 25%. The total survival of the allografts was 80.8% (± 18.7%) after five years. We found a five-year allograft survival of 80.8% which is comparable with other studies

Northern Adriatic response to a wintertime bora wind event

The unprecedented suite of research activities that focused on the Adriatic in winter 2003 provided a multi-faceted view of bora events and the resulting oceanic response

Bora event variability and the role of air-sea feedback

Author Posting. © American Geophysical Union, 2007. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 112 (2007): C03S18, doi:10.1029/2006JC003726.A two-way interacting high resolution numerical simulation of the Adriatic Sea using the Navy Coastal Ocean Model (NCOM) and Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS®) was conducted to improve forecast momentum and heat flux fields, and to evaluate surface flux field differences for two consecutive bora events during February 2003. (COAMPS® is a registered trademark of the Naval Research Laboratory.) The strength, mean positions and extensions of the bora jets, and the atmospheric conditions driving them varied considerably between the two events. Bora 1 had 62% stronger heat flux and 51% larger momentum flux than bora 2. The latter displayed much greater diurnal variability characterized by inertial oscillations and the early morning strengthening of a west Adriatic barrier jet, beneath which a stronger west Adriatic ocean current developed. Elsewhere, surface ocean current differences between the two events were directly related to differences in wind stress curl generated by the position and strength of the individual bora jets. The mean heat flux bias was reduced by 72%, and heat flux RMSE reduced by 30% on average at four instrumented over-water sites in the two-way coupled simulation relative to the uncoupled control. Largest reductions in wind stress were found in the bora jets, while the biggest reductions in heat flux were found along the north and west coasts of the Adriatic. In bora 2, SST gradients impacted the wind stress curl along the north and west coasts, and in bora 1 wind stress curl was sensitive to the Istrian front position and strength. The two-way coupled simulation produced diminished surface current speeds of ∼12% over the northern Adriatic during both bora compared with a one-way coupled simulation.The research support for J. Pullen, J. D. Doyle, and T. Haack was provided by the Office of Naval Research (ONR) program elements 0602435N and 0601153N

Spontaneous regression of Merkel cell carcinoma in a patient with chronic lymphocytic leukemia: a case report

© 2009 Turk et al; licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

The ocean sampling day consortium.

Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world's oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits