A cortical potential reflecting cardiac function

Emotional trauma and psychological stress can precipitate cardiac arrhythmia and sudden death through arrhythmogenic effects of efferent sympathetic drive. Patients with preexisting heart disease are particularly at risk. Moreover, generation of proarrhythmic activity patterns within cerebral autonomic centers may be amplified by afferent feedback from a dysfunctional myocardium. An electrocortical potential reflecting afferent cardiac information has been described, reflecting individual differences in interoceptive sensitivity (awareness of one's own heartbeats). To inform our understanding of mechanisms underlying arrhythmogenesis, we extended this approach, identifying electrocortical potentials corresponding to the cortical expression of afferent information about the integrity of myocardial function during stress. We measured changes in cardiac response simultaneously with electroencephalography in patients with established ventricular dysfunction. Experimentally induced mental stress enhanced cardiovascular indices of sympathetic activity (systolic blood pressure, heart rate, ventricular ejection fraction, and skin conductance) across all patients. However, the functional response of the myocardium varied; some patients increased, whereas others decreased, cardiac output during stress. Across patients, heartbeat-evoked potential amplitude at left temporal and lateral frontal electrode locations correlated with stress-induced changes in cardiac output, consistent with an afferent cortical representation of myocardial function during stress. Moreover, the amplitude of the heartbeat-evoked potential in the left temporal region reflected the proarrhythmic status of the heart (inhomogeneity of left ventricular repolarization). These observations delineate a cortical representation of cardiac function predictive of proarrhythmic abnormalities in cardiac repolarization. Our findings highlight the dynamic interaction of heart and brain in stress-induced cardiovascular morbidity

NICMOS2 hubble space telescope observations of the embedded cluster associated with Mon R2: Constraining the substellar initial mass function

We have analyzed Hubble Space Telescope NICMOS2 F110W-, F160W-, F165M-, and F207M-band images covering the central 1' × 1' region of the cluster associated with Mon R2 in order to constrain the initial mass function (IMF) down to 20M_J. The flux ratio between the F165M and F160W bands was used to measure the strength of the water-band absorption feature and select a sample of 12 out of the total sample of 181 objects that have effective temperatures between 2700 and 3300 K. These objects are placed in the H-R diagram together with sources observed by Carpenter et al. to estimate an age of ~1 Myr for the low-mass cluster population. By constructing extinction-limited samples, we are able to constrain the IMF and the fraction of stars with a circumstellar disk in a sample that is 90% complete for both high- and low-mass objects. For stars with estimated masses between 0.1 and 1.0 M_☉ for a 1 Myr population with A_V ≤ 19 mag, we find that 27% ± 9% have a near-infrared excess indicative of a circumstellar disk. The derived fraction is similar to or slightly lower than the fraction found in other star-forming regions of comparable age. We constrain the number of stars in the mass interval 0.08-1.0 M_☉ to the number of objects in the mass interval 0.02-0.08 M_☉ by forming the ratio R^(**) = N(0.08-1 M_☉)/N(0.02-0.08 M_☉) for objects in an extinction-limited sample complete for A_V ≤ 7 mag. The ratio is found to be R^(**) = 2.2 ± 1.3, assuming an age of 1 Myr, consistent with the similar ratio predicted by the system IMF proposed by Chabrier. The ratio is similar to the ratios observed toward the Orion Nebula Cluster and IC 348, as well as the ratio derived in the 28 deg^2 survey of Taurus by Guieu et al

Correlated dynamics of inclusions in a supported membrane

The hydrodynamic theory of heterogeneous fluid membranes is extended to the case of a membrane adjacent to a solid substrate. We derive the coupling diffusion coefficients of pairs of membrane inclusions in the limit of large separation compared to the inclusion size. Two-dimensional compressive stresses in the membrane make the coupling coefficients decay asymptotically as $1/r^2$ with interparticle distance $r$. For the common case, where the distance to the substrate is of sub-micron scale, we present expressions for the coupling between distant disklike inclusions, which are valid for arbitrary inclusion size. We calculate the effect of inclusions on the response of the membrane and the associated corrections to the coupling diffusion coefficients to leading order in the concentration of inclusions. While at short distances the response is modified as if the membrane were a two-dimensional suspension, the large-distance response is not renormalized by the inclusions.Comment: 15 page

Imaging the source region of the 2003 San Simeon earthquake within the weak Franciscan subduction complex, central California

Data collected from the 2003 Mw6.5 San Simeon earthquake sequence in central California and a 1986 seismic refraction experiment demonstrate that the weak Franciscan subduction complex suffered brittle failure in a region without significant velocity contrast across a slip plane. Relocated hypocenters suggest a spatial relationship between the seismicity and the Oceanic fault, although blind faulting on a nearby, unknown fault is an equally plausible alternative. The aftershock volume is sandwiched between the Nacimiento and Oceanic faults and is characterized by rocks of low compressional velocity (Vp) abutted to the east and west by rocks of higher Vp. This volume of inferred Franciscan rocks is embedded within the larger Santa Lucia anticline. Pore fluids, whose presence is implied by elevated Vp/Vs values, may locally decrease normal stress and limit the aftershock depth distribution between 3 to 10 km within the hanging wall. The paucity of aftershocks along the mainshock rupture surface may reflect either the absence of a damage zone or an almost complete stress drop within the low Vp or weak rock matrix surrounding the mainshock rupture

Soluble silicon patterns and templates: calcium phosphate nanocrystal deposition in collagen type 1

Patterned mineralisation is a feature of many hard-tissues. The impressive mechanical properties exhibited by such tissues can be, in part, attributed to the patterned deposition of mineral within the organic matrix. Although not thermodynamically favourable, the deposition of calcium phosphate based mineral within collagen fibres occurs in vivo in bone and dentine. As a consequence, numerous researchers have investigated how matrix proteins may be conditioned to enable patterned mineral deposition to recapitulate the structures found in nature. In this study, we have demonstrated that this patterned mineralisation of collagen type I may be induced simply by the pretreatment of the collagen with orthosilicic acid (OSA). The OSA treatment of the collagen resulted in a structural change to the collagen fibres, modifying fibril diameter and changing the kinetics of fibre formation. NMR demonstrated that the OSA preferentially located to the termini of the procollagen fibrils, thereby templating the formation of apatitic calcium phosphate crystals within the collagen fibrils (as shown using TEM, EDX and SAED). This work demonstrates how simple inorganic ions can have potent effects on structuring biological precipitates and suggests why trace quantities of silicon ions are essential to the formation of healthy hard tissues

Eigenvalues of the 2p3pP3 and 2p3dD1,3 bound states of the helium isoelectronic sequence

The 1Z expansion method is used to calculate the eigenvalues of the 2p3pP3 and 2p3dD1,3 states of the helium isoelectronic sequence. The results are compared to variational calculations for neutral helium. Wavelengths are predicted for a number of transitions originating in doubly excited states of the heliumlike ions up to Fe xxv. The results for neutral helium are compared to recent beam-foil experiments and alternative line identifications are made. The predicted wavelength for the 2p3dD3-2p2P3 transition is 3014, in close agreement with the line observed by Berry et al. at 3012 ± 2. © 1972 The American Physical Society