Topography driven spreading

Roughening a hydrophobic surface enhances its nonwetting properties into superhydrophobicity. For liquids other than water, roughness can induce a complete rollup of a droplet. However, topographic effects can also enhance partial wetting by a given liquid into complete wetting to create superwetting. In this work, a model system of spreading droplets of a nonvolatile liquid on surfaces having lithographically produced pillars is used to show that superwetting also modifies the dynamics of spreading. The edge speed-dynamic contact angle relation is shown to obey a simple power law, and such power laws are shown to apply to naturally occurring surfaces

Spectral Cross-calibration of the Konus-Wind, the Suzaku/WAM, and the Swift/BAT Data using Gamma-Ray Bursts

We report on the spectral cross-calibration results of the Konus-Wind, the Suzaku/WAM, and the Swift/BAT instruments using simultaneously observed gamma-ray bursts (GRBs). This is the first attempt to use simultaneously observed GRBs as a spectral calibration source to understand systematic problems among the instruments. Based on these joint spectral fits, we find that 1) although a constant factor (a normalization factor) agrees within 20% among the instruments, the BAT constant factor shows a systematically smaller value by 10-20% compared to that of Konus-Wind, 2) there is a systematic trend that the low-energy photon index becomes steeper by 0.1-0.2 and Epeak becomes systematically higher by 10-20% when including the BAT data in the joint fits, and 3) the high-energy photon index agrees within 0.2 among the instruments. Our results show that cross-calibration based on joint spectral analysis is an important step to understanding the instrumental effects which could be affecting the scientific results from the GRB prompt emission data.Comment: 82 pages, 88 figures, accepted for publication in PAS

Observations of the Prompt Gamma-Ray Emission of GRB 070125

The long, bright gamma-ray burst GRB 070125 was localized by the Interplanetary Network. We present light curves of the prompt gamma-ray emission as observed by Konus-WIND, RHESSI, Suzaku-WAM, and \textit{Swift}-BAT. We detail the results of joint spectral fits with Konus and RHESSI data. The burst shows moderate hard-to-soft evolution in its multi-peaked emission over a period of about one minute. The total burst fluence as observed by Konus is $1.79 \times 10^{-4}$ erg/cm$^2$ (20 keV--10 MeV). Using the spectroscopic redshift $z=1.548$, we find that the burst is consistent with the ``Amati'' $E_{peak,i}-E_{iso}$ correlation. Assuming a jet opening angle derived from broadband modeling of the burst afterglow, GRB 070125 is a significant outlier to the ``Ghirlanda'' $E_{peak,i}-E_\gamma$ correlation. Its collimation-corrected energy release $E_\gamma = 2.5 \times 10^{52}$ ergs is the largest yet observed.Comment: 25 pages, 6 figures; accepted for publication in ApJ. Improved spectral fits and energetics estimate

Down-regulation of transcription elogation factor A (SII) like 4 (TCEAL4) in anaplastic thyroid cancer

BACKGROUND: Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies and appears to arise mainly from transformation of pre-existing differentiated thyroid cancer (DTC). However, the carcinogenic mechanism of anaplastic transformation remains unclear. Previously, we investigated specific genes related to ATC based on gene expression profiling using cDNA microarray analysis. One of these genes, transcription elongation factor A (SII)-like 4 (TCEAL4), encodes a member of the transcription elongation factor A (SII)-like gene family. The detailed function of TCEAL4 has not been described nor has any association between this gene and human cancers been reported previously. METHODS: To investigate the role of TCEAL4 in ATC carcinogenesis, we examined expression levels of TCEAL4 in ACLs as well as in other types of thyroid cancers and normal human tissue. RESULTS: Expression of TCEAL4 was down-regulated in all 11 ACLs as compared to either normal thyroid tissues or papillary and follicular thyroid cancerous tissues. TCEAL4 was expressed ubiquitously in all normal human tissues tested. CONCLUSION: To our knowledge, this is the first report of altered TCEAL4 expression in human cancers. We suggest that loss of TCEAL4 expression might be associated with development of ATC from DTC. Further functional studies are required

A parameterization of flow separation over subaqueous dunes

Flow separation plays a key role in the development of dunes, and modeling the complicated flow behavior inside the flow separation zone requires much computational effort. To make a first step toward modeling dune development at reasonable temporal and spatial scales, a parameterization of the shape of the flow separation zone over two-dimensional dunes is proposed herein, in order to avoid modeling the complex flow inside the flow separation zone. Flow separation behind dunes, with an angle-of-repose slip face, is characterized by a large circulating leeside eddy, where a separation streamline forms the upper boundary of the recirculating eddy. Experimental data of turbulent flow over two-dimensional subaqueous bed forms are used to parameterize this separation streamline. The bed forms have various heights and height to length ratios, and a wide range of flow conditions is analyzed. This paper shows that the shape of the flow separation zone can be approximated by a third-order polynomial as a function of the distance away from the flow separation point. The coefficients of the polynomial can be estimated, independent of flow conditions, on the basis of bed form shape at the flow separation point and a constant angle of the separation streamline at the flow reattachment point. \ud \u

Drop impact upon micro- and nanostructured superhydrophobic surfaces

We experimentally investigate drop impact dynamics onto different superhydrophobic surfaces, consisting of regular polymeric micropatterns and rough carbon nanofibers, with similar static contact angles. The main control parameters are the Weber number \We and the roughness of the surface. At small \We, i.e. small impact velocity, the impact evolutions are similar for both types of substrates, exhibiting Fakir state, complete bouncing, partial rebouncing, trapping of an air bubble, jetting, and sticky vibrating water balls. At large \We, splashing impacts emerge forming several satellite droplets, which are more pronounced for the multiscale rough carbon nanofiber jungles. The results imply that the multiscale surface roughness at nanoscale plays a minor role in the impact events for small \We \apprle 120 but an important one for large \We \apprge 120. Finally, we find the effect of ambient air pressure to be negligible in the explored parameter regime \We \apprle 150Comment: 8 pages, 7 figure

Decreased expression of haemoglobin beta (HBB) gene in anaplastic thyroid cancer and recovory of its expression inhibits cell growth

Anaplastic thyroid cancer (ATC) is one of the most fulminant and foetal diseases in human malignancies. However, the genetic alterations and carcinogenic mechanisms of ATC are still unclear. Recently, we investigated the gene expression profile of 11 anaplastic thyroid cancer cell lines (ACL) and significant decreased expression of haemoglobin beta (HBB) gene in ACL. Haemoglobin beta is located at 11p15.5, where loss of heterozygosity (LOH) was reported in various kinds of cancers, including ATC, and it has been suggested that novel tumour suppressor genes might exist in this region. In order to clarify the meaning of decreased expression of HBB in ATC, the expression status of HBB was investigated with ACL, ATC, papillary thyroid cancer (PTC) and normal human tissues. Haemoglobin beta showed significant decreased expression in ACLs and ATCs; however, in PTC, HBB expressed equal to the normal thyroid gland. In addition, HBB expressed in normal human tissues ubiquitously. To validate the tumour-suppressor function of HBB, cell growth assay was performed. Forced expression of HBB in KTA2 cell, which is a kind of ACL, significantly suppressed KTA2 growth. The mechanism of downregulation of HBB in ATC is still unclear; however, our results suggested the possibility of HBB as a novel tumour-suppressor gene

Status of GRB Observations with the Suzaku Wideband All-sky Monitor

The Wide-band All-sky Monitor (WAM) is a function of the large lateral BGO shield of the Hard X-ray Detector (HXD) onboard Suzaku. Its large geometrical area of 800 cm^2 per side, the large stopping power for the hard X-rays and the wide-field of view make the WAM an ideal detector for gamma-ray bursts (GRBs) observations in the energy range of 50-5000 keV. In fact, the WAM has observed 288 GRBs confirmed by other satellites, till the end of May 2007.Comment: 4 pages, 4 figures, to be published in the proceedings of ''Gamma Ray Bursts 2007'', Santa Fe, New Mexico, November 5-

Can we live on a D-brane? -- Effective theory on a self-gravitating D-brane --

We consider a D-brane coupled with gravity in type IIB supergravity on S^5 and derive the effective theory on the D-brane in two different ways, that is, holographic and geometrical projection methods. We find that the effective equations on the brane obtained by these methods coincide. The theory on the D-brane described by the Born-Infeld action is not like Einstein-Maxwell theory in the lower order of the gradient expansion, i.e., the Maxwell field does not appear in the theory. Thus the careful analysis and statement for cosmology on self-gravitating D-brane should be demanded in realistic models.Comment: 13 pages, accepted for publication in Physical Review