Let’s hear it for passion in pharmacy!

Passion sets the heart racing . . . can it be applied to the profession of pharmacy

Let’s hear it for passion in pharmacy!

Passion sets the heart racing . . . can it be applied to the profession of pharmacy

To evaluate a protocol for prompt migration from an unlicensed to a licensed product using the NHS change model in a paediatric cardiology setting

The use of unlicensed medicines for infants and children is a well documented issue. A review in five hospitals showed over half of prescriptions were either unlicensed or off-label.1 A marketing authorisation (also known as licensing) decision in medicine is based on a judgement that benefits outweigh the potential risks. Furthermore a licensed medication has been assessed for efficacy, safety and quality; has been manufactured to appropriate quality standards; and when placed on the market is accompanied by appropriate product information and labelling

The Generalized Odd Generalized Exponential Gompertz Distribution with Applications

Communication in Physical Sciences, 2023, 10(1): 163-171 Authors: Gulumbe S. Usman, Umar Usman, Aremu Kazeem Olalekan, Odeyale, Abideen Babatunde Received:  21 October 2023/Accepted 10 November 2023 This study introduces the generalized odd generalized exponential Gompertz distribution. Some mathematical properties were derived, which increase the subject distribution's flexibility by allowing the model to be used for the analysis of a variety of lifetime data types with hazard rates that are monotonic, upside-down, and bathtub-shaped. The new model includes two additional parameters as a mixture of the odd exponential-G family of distributions. The observed Fisher's information matrix was constructed, and the model parameters were estimated using the maximum likelihood method. Through a numerical analysis using actual data, we demonstrate the effectiveness of the suggested model

A QSPR analysis of physical properties of antituberculosis drugs using neighbourhood degree-based topological indices and support vector regression

Topological indices are molecular descriptors used in QSPR modelling to predict the physicochemical properties of molecules. Topological indices are used in numerous applications in drug design. In this work, we compute the neighbourhood degree-based topological indices of 15 antituberculosis drugs, we studied the QSPR analysis of these drugs using support vector regression. The efficiency of support vector regression is determined by comparing it with the classical linear regression. Our QSPR model further shows the superiority of the SVR model as a better predictive model in QSPR analysis of the physical properties of antituberculosis drugs. The findings in this study are a further contribution to the field of chemical graph theory and drug design, providing a deeper understanding of neighbourhood degree-based topological indices and their predictive capabilities in QSPR model

Tolvaptan treatment for severe neonatal autosomal-dominant polycystic kidney disease

Severe neonatal autosomal-dominant polycystic kidney disease (ADPKD) is rare and easily confused with recessive PKD. Managing such infants is difficult and often unsuccessful

A Multi-objectives regression, optimization and risk assessment of profitability indicators of the simulation of mini Liquefied Petroleum Gas (LPG) dispensing unit

In this study, simulation of a mini Liquefied Petroleum Gas (LPG) dispensing unit was conducted using ASPEN HYSYS and the operation of both compressor and pump were validated theoretically. The effect of the economic parameters (Total Annual Sales (TAS), Total Production Cost (TPC), Fixed Capital Investment (FCI) and interest rate (r)) on the behaviour of three profitability indicators (Net Present Value (NPV), Return on investment (ROI) and Internal Rate of Return (IRR)) were modelled and optimized using Box Behnken Design (BBD). The uncertainty of the developed models was determined using Oracle Crystal Ball (ORB). The optimum economic parameters, TAS of ₦48,830,600, FCI of ₦37,422,000, TPC of ₦35, 053,000 and r of 5.4% predicted optimum profitability indicators are ROI of 34.6%, NPV of ₦98,993,580.25 and IRR of 34.15% for 15 years’ investment plan. An interaction of the economic parameters showed that for NPV to be positive, TAS value should be greater than ₦42.5 million and the TPC should be less or equal to ₦36 million. The profitability analysis suggested that this investment will pay back in 2.36 years. Given that the demand of LPG is on the increase and therefore, this LPG plant will be a long term investment with a good return on investment

Chapter Four - Effect of evaporative cooling on the attributes of nonclimacteric fruits

Nonclimacteric fruits are among the most delicate crops, and precooling enhances the proportion of these fruits. Modifications have been made to the homogeneous nonclimacteric fruit refrigerating procedure in order to provide a better simultaneous ventilation mechanism. It has been discovered that the initial temperature of nonclimacteric fruits could be modeled, employing computational equations of temperature, velocity, and transport phenomena that have been scientifically confirmed to assess their effectiveness