891 research outputs found
Weak Lensing Mass Reconstruction: Flexion vs Shear
Weak gravitational lensing has proven to be a powerful tool to map directly
the distribution of dark matter in the Universe. The technique, currently used,
relies on the accurate measurement of the gravitational shear that corresponds
to the first-order distortion of the background galaxy images. More recently, a
new technique has been introduced that relies on the accurate measurement of
the gravitational flexion that corresponds to the second-order distortion of
the background galaxy images. This technique should probe structures on smaller
scales than that of a shear analysis. The goal of this paper is to compare the
ability of shear and flexion to reconstruct the dark matter distribution by
taking into account the dispersion in shear and flexion measurements. Our
results show that the flexion is less sensitive than shear for constructing the
convergence maps on scales that are physically feasible for mapping, meaning
that flexion alone not be used to do convergence map reconstruction, even on
small scales.Comment: Submitted to Ap
Bac-pool Sequencing And Assembly Of 19 Mb Of The Complex Sugarcane Genome
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sequencing plant genomes are often challenging because of their complex architecture and high content of repetitive sequences. Sugarcane has one of the most complex genomes. It is highly polyploid, preserves intact homeologous chromosomes from its parental species and contains 55% repetitive sequences. Although bacterial artificial chromosome (BAC) libraries have emerged as an alternative for accessing the sugarcane genome, sequencing individual clones is laborious and expensive. Here, we present a strategy for sequencing and assembly reads produced from the DNA of pooled BAC clones. A set of 178 BAC clones, randomly sampled from the SP80-3280 sugarcane BAC library, was pooled and sequenced using the Illumina HiSeq2000 and PacBio platforms. A hybrid assembly strategy was used to generate 2,451 scaffolds comprising 19.2 MB of assembled genome sequence. Scaffolds of >= 20 Kb corresponded to 80% of the assembled sequences, and the full sequences of forty BACs were recovered in one or two contigs. Alignment of the BAC scaffolds with the chromosome sequences of sorghum showed a high degree of collinearity and gene order. The alignment of the BAC scaffolds to the 10 sorghum chromosomes suggests that the genome of the SP80-3280 sugarcane variety is similar to 19% contracted in relation to the sorghum genome. In conclusion, our data show that sequencing pools composed of high numbers of BAC clones may help to construct a reference scaffold map of the sugarcane genome.7[FAPESP - 10/50114-4]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP
Gravitational Flexion by Elliptical Dark Matter Haloes
We present equations for the gravitational lensing flexion expected for an
elliptical lens mass distribution. These can be reduced to one-dimensional
finite integrals, thus saving significant computing time over a full
two-dimensional calculation. We estimate constraints on galaxy halo
ellipticities for a range of potential future surveys, finding that the
constraints from the two different types of flexion are comparable and are up
to two orders of magnitude tighter than those from shear. Flexion therefore
appears to be a very promising potential tool for constraining the shapes of
galaxy haloes from future surveys.Comment: 7 pages, 5 figures, submitted to MNRA
A New Constraint on the Ly Fraction of UV Very Bright Galaxies at Redshift 7
We study the extent to which very bright (-23.0 < MUV < -21.75) Lyman-break
selected galaxies at redshifts z~7 display detectable Lya emission. To explore
this issue, we have obtained follow-up optical spectroscopy of 9 z~7 galaxies
from a parent sample of 24 z~7 galaxy candidates selected from the 1.65 sq.deg
COSMOS-UltraVISTA and SXDS-UDS survey fields using the latest near-infrared
public survey data, and new ultra-deep Subaru z'-band imaging (which we also
present and describe in this paper). Our spectroscopy has yielded only one
possible detection of Lya at z=7.168 with a rest-frame equivalent width EW_0 =
3.7 (+1.7/-1.1) Angstrom. The relative weakness of this line, combined with our
failure to detect Lya emission from the other spectroscopic targets allows us
to place a new upper limit on the prevalence of strong Lya emission at these
redshifts. For conservative calculation and to facilitate comparison with
previous studies at lower redshifts, we derive a 1-sigma upper limit on the
fraction of UV bright galaxies at z~7 that display EW_0 > 50 Angstrom, which we
estimate to be < 0.23. This result may indicate a weak trend where the fraction
of strong Lya emitters ceases to rise, and possibly falls between z~6 and z~7.
Our results also leave open the possibility that strong Lya may still be more
prevalent in the brightest galaxies in the reionization era than their fainter
counterparts. A larger spectroscopic sample of galaxies is required to derive a
more reliable constraint on the neutral hydrogen fraction at z~7 based on the
Lya fraction in the bright galaxies.Comment: 20 pages, 7 figures, accepted for publication in Ap
Probiotics in Diverticular Disease of the Colon: an Open Label Study
Aim: To investigate the effectiveness and safety of a symbiotic mixture in preventing recurrence of constipation-related abdominal pain in patients with uncomplicated diverticular disease of the colon.
Methods: Forty-six consecutive patients (10 men, 36 women, mean age 62.5 years, range 49 to 77 years), previously affected by symptomatic uncomplicated diverticular disease of the colon, were enrolled in a 6-month follow-up study in a prospective, randomized, open-label study. The following symptoms were assessed at entry and through follow-up by using a quantitative scale: constipation, diarrhoea and abdominal pain. After recruitment, the patients were assigned to the following treatment: SCM-III symbiotic mixture, 10ml three times a day. The colonization of ingested Lactobacillus acidophilus 145 and Bifidobacterium spp. 420 was assessed by specie-specific PCR. Forty-five patients completed the study (97%).
Results: Thirty-one patients (68%) were still symptom free after the 6th month of treatment. Treatment with SCM-III was regarded as "effective" or "very effective" in more than 78% of the patients altogether (p<0.01 vs baseline values). The microbiological study showed that, as compared to baseline values, SCM-III enabled a significant increase of the lactobacilli and bifidobacteria counting and a trend decrease of clostridia. Genomic analysis confirmed the survivability of the ingested strain as long as treatment was given.
Conclusions: The present symbiotic mixture seems to be effective in preventing recurrence of symptomatic uncomplicated diverticular disease of the colon, especially in those patients with constipation-predominant features
Impact of Diabetes on Work Cessation: Data from the GAZEL cohort study
International audienceOBJECTIVE: To measure the impact of diabetes on work cessation, i.e., on the risks of work disability, early retirement, and death while in the labor force. RESEARCH DESIGN AND METHODS: We used data from the GAZEL prospective cohort of 20,625 employees of the French national gas and electricity company "EDF-GDF." We identified 506 employees with diabetes and randomly selected 2,530 nondiabetic employed control subjects matched for major sociodemographic and occupational characteristics. Using a multistate Cox model, we estimated hazard ratios (HRs) comparing the risks of transition from employment to disability, retirement, and death over time between participants with versus without diabetes. RESULTS: Employment rate decreased more rapidly in participants with diabetes (51.9 and 10.1% at 55 and 60 years, respectively) compared with nondiabetic participants (66.5 and 13.4%, respectively). Participants with diabetes had significantly increased risks of transition from employment to disability (HR 1.7 [95% CI 1.0-2.9]), retirement (HR 1.6 [1.5-1.8]), and death (HR 7.3 [3.6-14.6]) compared with participants without diabetes. Between 35 and 60 years, each participant with diabetes lost an estimated mean time of 1.1 year in the workforce (95% CI 0.99-1.14) compared with a nondiabetic participant. CONCLUSIONS: Our results provide evidence for a profound negative impact of diabetes on workforce participation in France. Social and economic consequences are major for patients, employers, and society-a burden that is likely to increase as diabetes becomes more and more common in the working-aged population
Constraining primordial non-Gaussianity with cosmological weak lensing: shear and flexion
We examine the cosmological constraining power of future large-scale weak
lensing surveys on the model of \emph{Euclid}, with particular reference to
primordial non-Gaussianity. Our analysis considers several different estimators
of the projected matter power spectrum, based on both shear and flexion, for
which we review the covariances and Fisher matrices. The bounds provided by
cosmic shear alone for the local bispectrum shape, marginalized over
, are at the level of . We consider
three additional bispectrum shapes, for which the cosmic shear constraints
range from (equilateral shape) up to (orthogonal shape). The competitiveness of cosmic
flexion constraints against cosmic shear ones depends on the galaxy intrinsic
flexion noise, that is still virtually unconstrained. Adopting the very high
value that has been occasionally used in the literature results in the flexion
contribution being basically negligible with respect to the shear one, and for
realistic configurations the former does not improve significantly the
constraining power of the latter. Since the flexion noise decreases with
decreasing scale, by extending the analysis up to
cosmic flexion, while being still subdominant, improves the shear constraints
by when added. However on such small scales the highly non-linear
clustering of matter and the impact of baryonic physics make any error
estimation uncertain. By considering lower, and possibly more realistic, values
of the flexion intrinsic shape noise results in flexion constraining power
being a factor of better than that of shear, and the bounds on
and being improved by a factor of upon
their combination. (abridged)Comment: 30 pages, 4 figures, 4 tables. To appear on JCA
GREAT3 results I: systematic errors in shear estimation and the impact of real galaxy morphology
We present first results from the third GRavitational lEnsing Accuracy
Testing (GREAT3) challenge, the third in a sequence of challenges for testing
methods of inferring weak gravitational lensing shear distortions from
simulated galaxy images. GREAT3 was divided into experiments to test three
specific questions, and included simulated space- and ground-based data with
constant or cosmologically-varying shear fields. The simplest (control)
experiment included parametric galaxies with a realistic distribution of
signal-to-noise, size, and ellipticity, and a complex point spread function
(PSF). The other experiments tested the additional impact of realistic galaxy
morphology, multiple exposure imaging, and the uncertainty about a
spatially-varying PSF; the last two questions will be explored in Paper II. The
24 participating teams competed to estimate lensing shears to within systematic
error tolerances for upcoming Stage-IV dark energy surveys, making 1525
submissions overall. GREAT3 saw considerable variety and innovation in the
types of methods applied. Several teams now meet or exceed the targets in many
of the tests conducted (to within the statistical errors). We conclude that the
presence of realistic galaxy morphology in simulations changes shear
calibration biases by per cent for a wide range of methods. Other
effects such as truncation biases due to finite galaxy postage stamps, and the
impact of galaxy type as measured by the S\'{e}rsic index, are quantified for
the first time. Our results generalize previous studies regarding sensitivities
to galaxy size and signal-to-noise, and to PSF properties such as seeing and
defocus. Almost all methods' results support the simple model in which additive
shear biases depend linearly on PSF ellipticity.Comment: 32 pages + 15 pages of technical appendices; 28 figures; submitted to
MNRAS; latest version has minor updates in presentation of 4 figures, no
changes in content or conclusion
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