First Report of Trichinella nativa in Red Foxes（Vulpes vulpes schrencki) from Otaru City,Hokkaido,Japan

北海道小樽市で捕獲された43頭のキタキツネと9頭のタヌキについて、筋肉中のトリヒナ線虫の寄生状況を調べた。そのうち5頭のキツネからトリヒナ線虫の一種Trichinella nativaの幼虫が検出された。この発見は、北海道でキタキツネが、トリヒナ線虫の野外型の生活環維持の重要な宿主であることを示唆している。北海道におけるキタキツネからT.nativaの寄生報告は、最初のものである

Dose dependency of prednisolone on the establishment of Echinococcus multilocularis infection in an alternative definitive host, Mongolian gerbil

This study revealed the dose dependency of prednisolone tertiary-butylacetate (PTBA) treatment on the establishment of Echinococcus multilocularis in the small intestine of Mongolian gerbil (Meriones unguiculatus) and that some of the physiological parameters of host were correlated with the doses of PTBA and establishment of the worm. Twenty Mongolian gerbils were divided into 5 groups, according to the doses of PTBA ; 0mg, 0.5mg, 2mg, 5mg and 10mg per head. All animals were injected intraperitoneally with PTBA every other day from 6 days before to 6 days after infection. Doses of PTBA and the number of worms recovered at 7 days post-infection showed a positive correlation (r=0.929, P<0.0001). The increase of total protein (TP) and the decrease of the percentage of lymphocytes in the peripheral leukocytes were dependent on doses of PTBA (TP : r=0.811, P<0.0001, percentage of lymphocyte : r=-0.92, P<0.0001). The TP and the percentage of lymphocyte also correlated with the number of worms recovered (TP : r=0.617, P=0.0049 ; percentage of lymphocyte : r=-0.800, P<0.0001)

First Report of Trichinella nativa in Red Foxes（Vulpes vulpes schrencki) from Otaru City,Hokkaido,Japan

北海道小樽市で捕獲された43頭のキタキツネと9頭のタヌキについて、筋肉中のトリヒナ線虫の寄生状況を調べた。そのうち5頭のキツネからトリヒナ線虫の一種Trichinella nativaの幼虫が検出された。この発見は、北海道でキタキツネが、トリヒナ線虫の野外型の生活環維持の重要な宿主であることを示唆している。北海道におけるキタキツネからT.nativaの寄生報告は、最初のものである

Clinical feature and anti-phospholipid antibody profiles of pregnancy failure in young women with antiphospholipid antibody syndrome treated with conventional therapy

<p><b>Objective:</b> To elucidate clinical feature and anti-phospholipid antibody (aPL) profiles, including lupus anticoagulant (LA), anti-cardiolipin (CL) antibodies and anti-phosphatidylserine/prothrombin (PS/PT) antibodies, of pregnancy failure in patients with antiphospholipid antibody syndrome (APS) already treated with conventional therapy.</p> <p><b>Materials and methods:</b> Thirty-four women with a history of pregnancy who were diagnosed with APS between 2008 and 2016 were included in the study. We defined the successful pregnancy group as women who gave birth to a healthy baby over 1500 g after 34 weeks of pregnancy under conventional treatment (heparin and/or low-dose aspirin). The unsuccessful pregnancy group was defined as women whose pregnancy outcomes did not meet the aforementioned criteria despite the conventional therapy. The clinical features and aPL profiles were compared between the two groups.</p> <p><b>Results:</b> Fifteen women were classified into the unsuccessful pregnancy group; seven women were in the successful pregnancy group. Having history of both thrombosis and pregnancy morbidity and LA positivity were significantly more prevalent in the unsuccessful pregnancy group than in the successful pregnancy group (<i>p</i> <.05, respectively). In contrast, single positivity of anti-CL antibody was negatively associated with APS-associated pregnancy morbidity under the conventional treatment (<i>p</i> <.01). The proportion of anti-PS/PT IgG-positive patients was significantly higher in the unsuccessful pregnancy group (<i>p =</i> .02, OR 18.7, 95% CI 1.50, 232.29) with high concordance rate with LA (97% consistence).</p> <p><b>Conclusion:</b> History of both thrombosis and pregnancy morbidity and the positivity of LA and/or anti-PS/PT-IgG, not but anti-CL-antibodies were correlated with APS-associated pregnancy morbidity refractory to conventional treatment. Clinical feature and aPL profiles might help us to make risk assessment for adverse pregnancy outcomes in patients with APS.</p