A Study on The Developmental Stages of Consultation Skills of Certified Nurses in A Hospitals

本研究の目的はA 病院で勤務する認定看護師の相談能力が発達する段階と能力を発達させるための方策を明らかにすることである．A 病院に勤務する認定看護師更新審査を経験した認定看護師9 名を対象に，フォーカス・グループ・インタビューによりデータ収集し分析した．認定看護師の相談能力は4 段階にわたって発達していることが明らかになり，相談活動の実践を可能にしている能力を【自分の持つ知識や技術を惜しみなく提供する思いを持ち，手探りながら地道に相談にチャレンジする能力】【相談対象と現場の理解に基づき，自立を目指して一緒に考えながら，専門知識と技術を駆使する能力】【周りの人と協働する関係性を築き，問題の本質に迫って目標を定め，人を巻き込んで解決に向ける能力】【部署を超えた周囲との信頼関係を前提に，ポジションパワーを活用し，未知の領域に踏み込み，組織的な課題の解決に向けチャレンジする能力】と命名した．また，能力を発達させるための方策として，『姿勢』『努力』『学び』というテーマで13 個の重要カテゴリーが抽出でき，加えて，役職と活動形態は相談能力の発達に影響する要因であることが明らかになった．認定看護師専門分野にかかわらず，相談能力には質的に異なる4 つの発達段階がある可能性が示された．各発達段階で示された能力は，自身の努力と管理者支援の方向性を考える参考になると考える．departmental bulletin pape

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

A educação pelo lazer num trabalho comunitario : iniciação ludica aos conteudos fisico-esportivos um estudo de caso

Tendo como tema às relações entre a Educação Física e o Lazer, este considerado como veículo e objeto de educação, a monografia centra a sua análise no trabalho que vem sendo desenvolvido na Sociedade Esportiva e Cultural Costa e Silva-Campinas-SP, em trabalho de extensão, assessorado pelo Departamento de Estudos de Lazer, da Faculdade de Educação Física, da Unicamp, utilizando como estratégia a Ação Comunitária e já situada na sua fase de autonomia. Examina, mais detidamente, o tratamento que é dado aos conteúdos físico-esportivos no lazer. O objetivo é analisar a maneira como o lazer (enquanto ensino não formal) é vivenciado numa comunidade que, através de serviços voluntários, utiliza-se dos conteúdos culturais físico-esportivos do lazer. Procura entender como vem se efetivando o trabalho sócio-educativo, visto de uma perspectiva comunitária, e no que ele pode contribuir para a Educação Física, enquanto conteúdo e forma, no processo de ensino-aprendizagem. Trata-se, assim, de um estudo de caso, com amostra definida de forma não-probabilística, intencional, combinando pesquisa bibliográfica, documental e de campo, esta última tendo a observação participante, com diário de campo, e a entrevista estruturada, como suas principais técnicas de coleta de dados. Os principais resultados apontam para a necessidade da recuperação do componente lúdico da cultura, nas aulas de Ed. Física Escolar, participação dos pais no desenvolvimento das atividades, e envolvimento da comunidade próxima.Not informed

Futebol espetaculo : a participação das torcidas organizadas

Não informado.Not informed