108 research outputs found
Research and development of an electron beam focusing system for a high-brightness X-ray generator
In order to minimize the size of the X-ray source for a U-shaped rotating anticathode X-ray generator, the electron beam is focused over a short distance by a combined-function bending magnet. Simulation predicts that the beam brightness will reach almost 500 kW mm−2 for a 120 keV/75 mA beam
GNSS Array Antenna for Mitigating Multipath Errors in Urban Environment
GNSS signal vulnerability has been a major concern especially for safety-of-life applications such as aircraft operations. Therefore, a GNSS array antenna technology was investigated focusing on beamforming to mitigate multipath errors in urban environment including airport surfaces. A commercial three-element GNSS antenna and RF-Front end were used to obtain digital IF data. The recorded In-phase/Quadrature IF data for three antennas were combined with proper weight to form beams towards satellites after so-called hardware biases were calibrated. Test results in multipath-rich environment demonstrated that 50-70% reduction of pseudorange errors due to multipath were possible if the beamforming algorithms were applied
Spiral Tissue Microarrays as Next Evolutionary Step in the High-density Tissue Microarray Technology
Tissue microarray (TMA) is a well-established technique that connects basic research with clinical applications that allow the validation of many pathobiologic events from gene expression dysregulation to genomic aberrations. However, conventional TMAs have several limitations such as limited representation of tissue heterogeneity, destruction of donor tissue blocks due to coring and usage of particular specimens that have limited evaluable material (tissue from thin specimens or needle biopsies). We have developed a novel method, which we termed "Spiral TMA" that generates TMAs that allow for improved representation of the donor tissue while keeping the architectural details of the donor block intact. This technology is ideal for specimens with limited tissue without the need to punch holes into the original block and therefore preserving the tissue integrity. In this report, we describe the methodology of constructing Spiral TMA and demonstrate the validation of tumor representation and tissue heterogeneity by comparing Spiral TMA to conventional TMA using immunohistochemical staining to EGFR and CK7
Angioscopic Evaluation of Stabilizing Effects of Bezafibrate on Coronary Plaques in Patients With Coronary Artery Disease
Background Since long-term administrations of anti-hyperlipidemic
agents result in reduction in % stenosis or increase in
minimum lumen diameter (MLD) of stenotic coronary
segments, it is generally believed that anti-hyperlipidemic agents
stabilize vulnerable coronary plaques. However, recent pathologic
and angioscopic studies revealed that vulnerability of coronary
plaques is not related to severity of stenosis and the rims rather
than top of the plaques disrupt, and therefore, angiography is not
adequate for evaluation of vulnerability
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