キロク カンリ ニオケル レコード キーパー ノ キノウ ト ヤクワリ ニ カンスル イチコウサツ オーストラリア ノ シュウ コウテキ キロクホウ ノ ジレイ カラ

電子記録の登場とともに、アーカイブズ機関・アーキビストはよりプロアクティブな関与が必要とされるが、2011年4月に施行された公文書管理法の行政文書の管理において、「アーカイブズ」あるいは「アーキビスト」の文言はみられず、法的な権限を有していない。質の高いアーカイブズを構築するためにも、現用文書の段階から適切な管理が必要であり、アーカイブズ機関やアーキビストがどのような役割を果たし、どう関与していくかが問題である。そこで、レコード・コンティニュアム理論を形成したオーストラリアにおいて、州政府の公的記録法によって、アーカイブズ機関及びアーキビストにどのような権限を法的に規定しているか、またその背景と、レコードキーパーとしての役割について考察を加える。アーカイブズ機関は記録管理における標準設定者、番犬役として、各種標準やスケジュールの設定を整備し、アカウンタビリティのエージェンシーとしてレコードキーピングに関与する役割を担っているのである。研究ノー

Non-Abelian Discrete Symmetries in Particle Physics

We review pedagogically non-Abelian discrete groups, which play an important role in the particle physics. We show group-theoretical aspects for many concrete groups, such as representations, their tensor products. We explain how to derive, conjugacy classes, characters, representations, and tensor products for these groups (with a finite number). We discussed them explicitly for $S_N$, $A_N$, $T'$, $D_N$, $Q_N$, $\Sigma(2N^2)$, $\Delta(3N^2)$, $T_7$, $\Sigma(3N^3)$ and $\Delta(6N^2)$, which have been applied for model building in the particle physics. We also present typical flavor models by using $A_4$, $S_4$, and $\Delta (54)$ groups. Breaking patterns of discrete groups and decompositions of multiplets are important for applications of the non-Abelian discrete symmetry. We discuss these breaking patterns of the non-Abelian discrete group, which are a powerful tool for model buildings. We also review briefly about anomalies of non-Abelian discrete symmetries by using the path integral approach.Comment: 179 pages, 8 figures, section 15 is changed, some references are adde

キロク カンリ ヒョウジュン ト カンシ カンサ ノ シクミ Australasia ノ コウ キロク カンリ ヲ ジレイ ニ

研究ノー

オーストラリア アーキビスト キョウカイ 2017 ネン タイカイ ニ サンカ シテ

報

Improving the Research Environment of High Performance Computing for Non-Cluster Experts Based on Knoppix Instant Computing Technology

Abstract. We have designed and implemented a new portable system that can rapidly construct a computer environment where highthroughput research applications can be performed instantly. One challenge in the instant computing area is constructing a cluster system instantly, and then readily restoring it to its former state. This paper presents an approach for instant computing using Knoppix technology that can allow even a non-computer specialist to easily construct and operate a Beowulf cluster . In the present bio-research field, there is now an urgent need to address the nagging problem posed by having highperformance computers. Therefore, we were assigned the task of proposing a way to build an environment where a cluster computer system can be instantly set up. Through such research, we believe that the technology can be expected to accelerate scientific research. However, when employing this technology in bio-research, a capacity barrier exists when selecting a clustered Knoppix system for a data-driven bioinformatics application. We have approached ways to overcome said barrier by using a virtual integrated RAM-DISK to adapt to a parallel file system. To show an actual example using a reference application, we have chosen InterProScan, which is an integrated application prepared by the European Bioinformatics Institute (EBI) that utilizes many database and scan methods. InterProScan is capable of scaling workload with local computational resources, though biology researchers and even bioinformatics researchers find such extensions difficult to set up. We have achieved the purpose of allowing even researchers who are non-cluster experts to easily build a system of "Knoppix for the InterProScan4.1 High Throughput Computing Edition." The system we developed is capable of not only constructing a cluster computer environment composed of 32 computers in about ten minutes (as opposed to six hours when done manually), but also restoring the original environment by rebooting the pre-existing operating system. The goal of our instant cluster computing is to provide an environment in which any target application can be built instantly from anywhere

オーストラリア アーキビスト キョウカイ 2016ネン タイカイ ニ サンカ シテ

報

Keeping Archives オ ヨム GCAS サブ ゼミナール 2011 カツドウ ホウコク

報

キロク ヲ マモル ノハ ダレカ アームストロング ジケン ガ シメシタ カダイ

研究ノー

GCAS サブゼミ 2018 2020 カツドウ ホウコク

報

Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor, and it is urgently needed to develop novel therapeutic strategies including immunotherapy. In this study, we investigated the upregulation of the programmed death ligand 1 (PD-L1) due to epithelial-mesenchymal transition (EMT) in ESCC using an in vitro treatment system with the EMT inducer, glycogen synthase kinase (GSK)-3 inhibitor, and we also analyzed the correlation of EMT and PD-L1 expression in the clinical tumor samples of both tissue microarray (TMA) samples (n = 177) and whole tissue samples (n = 21). As a result, the inhibition of GSK-3β induces EMT phenotype with upregulated vimentin and downregulated E-cadherin as well as increased Snail and Zinc finger E box-binding homeobox (ZEB)-1 gene expression. Simultaneously, we showed that EMT-converted ESCC indicated the upregulation of PD-L1 at both protein (total and surface) and mRNA levels. Of importance, we showed that EMT-converted tumor cells have a capability to induce T-cell apoptosis to a greater extent in comparison to original epithelial type tumor cells. Furthermore, the immunohistochemical stains of ESCC showed that PD-L1 expression on tumor cells was positively correlated with EMT status in TMA samples (P = .0004) and whole tissue samples (P = .0029). In conclusion, our in vitro and in vivo study clearly demonstrated that PD-L1 expression was upregulated in mesenchymal type tumors of ESCC. These findings provide a strong rationale for the clinical use of anti-PD- 1/ anti-PD- L1 monoclonal antibodies for advanced ESCC patients