10 research outputs found
An Examination of the Influence of Housing Attributes on Residential Property Rental Value in South-western Nigeria Using the Hedonic Pricing Model
This study adopts the hedonic pricing model to examine the influence of housing attributes on residential property rental value in south-western, Nigeria. This is to provide information on the housing attributes that could increase residential property rental values based on the current market situation. The study used primary data and employed quantitative data analysis. The data obtained were analysed using descriptive and inferential statistics. The study revealed the significant factors that influence rental value across different residential property types in south-western Nigeria. The paper is significant because it provides the necessary information on the influence of housing attributes in the study area. Hence, it enhances increasing knowledge in profitability, which could shape both local and foreign investors\u27 investment decisions
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
Evaluation of extraction and enrichment methods for recovery of respiratory RNA viruses in a metagenomics approach
Longitudinal analysis of the enteric virome in paediatric subjects from the Free State Province, South Africa, reveals early gut colonisation and temporal dynamics
The gut of healthy neonates is devoid of viruses at birth, but rapidly becomes colonised by normal viral commensals that aid in important physiological functions like metabolism but can, in some instances, result in gastrointestinal illnesses. However, little is known about how this colonisation begins, its variability and factors shaping the gut virome composition. Thus, understanding the development, assembly, and progression of enteric viral communities over time is key. To explore early-life virome development, metagenomic sequencing was employed in faecal samples collected longitudinally from a cohort of 17 infants during their first six months of life. The gut virome analysis revealed a diverse and dynamic viral community, formed by a richness of different viruses infecting humans, non-human mammals, bacteria, and plants. Eukaryotic viruses were detected as early as one week of life, increasing in abundance and diversity over time. Most of the viruses detected are commonly associated with gastroenteritis and include members of the Caliciviridae, Picornaviridae, Astroviridae, Adenoviridae, and Sedoreoviridae families. The most common co-occurrences involved asymptomatic norovirus-parechovirus, norovirus-sapovirus, sapovirus-parechovirus, observed in at least 40 % of the samples. Majority of the plant-derived viruses detected in the infants’ gut were from the Virgaviridae family. This study demonstrates the first longitudinal characterisation of the gastrointestinal virome in infants, from birth up to 6 months of age, in sub-Saharan Africa. Overall, the findings from this study delineate the composition and variability of the healthy infants’ gut virome over time, which is a significant step towards understanding the dynamics and biogeography of viral communities in the infant gut
Statement of Peer Review
In submitting conference proceedings to Proceedings, the volume editors of the proceedings certify to the publisher that all papers published in this volume have been subjected to peer review administered by the volume editors [...
Preface: 2nd Edition of the West and Central African Council for Agricultural Research and Development’s Symposium on “Processing and Transformation of Agricultural Products in West and Central Africa: Achievements and Opportunities for Private Sector Engagement”
The agricultural sector faces new challenges, including pest and disease outbreaks, land degradation, and the effects of climate change [...
Household food insecurity and cooking energy access in Nigeria: A panel data approach
Access to sources of cooking energy has potential impacts on food security, however, there is a paucity of information and empirical evidence on their linkages. This study sought to ascertain the impacts of access to cooking energy on household food security in Nigeria, using the nationally representative Living Standards Measurement Study data. The data covered the period 2010/2011 to 2015/2016. The Household Dietary Diversity Score (HDDS), and the Household Food Insecurity Access Scale (HFIAS) were used to measure household food security, while the major cooking fuel type utilized by households was used as a proxy for cooking energy access. To unravel the effects of access to different cooking energy sources on food security, inferential analysis was conducted using the Generalized Estimating Equations (GEE). The findings of the study revealed that traditional/biomass (firewood, grass and charcoal) cooking energy sources are still widely used by households across Nigeria. The empirical analysis showed that households that use transition and clean cooking energy sources were eating more diverse diets than those that use biomass. Furthermore, households using clean cooking energy sources had lower HFIAS than those using biomass. It is imperative that more households in Nigeria should have improved access to cleaner sources of cooking energy to reduce carbon emissions and enhance health outcomes, and food and nutrition status. This will significantly improve the national food security outlook, and foster the attainment of national and SDG (2 and 7) goals
