Individual Education Support System Using ICT for Developmental Disabilities

Children with developmental disabilities require special support to help them in different aspects of daily life, and individual educational support is a crucial part of such support. We developed a collaborative system for supporting children with developmental disabilities using ICT to be used by teachers, parents, and supporters. This chapter introduces this system, which provides close and immediate support through instantaneously sharing daily behavior information about the child between teacher-parent-supporters. In addition, storing the data in a highly secure cloud system facilitates passing information to children’s next educational level. Moreover, AI can match support needs and support services according to the characteristics of individual children by using ICF codes for suggesting immediate, dynamic support

Room-Temperature Reversible Chemisorption of Carbon Monoxide on Nickel(0) Complexes

Chemisorption on organometallic-based adsorbents is crucial for the controlled separation and long-term storage of gaseous molecules. The formation of covalent bonds between the metal centers in the adsorbents and the targeted gases affects the desorption efficiency, especially when the oxidation state of the metal is low. Herein, we report a pressure-responsive nickel(0)-based system that is able to reversibly chemisorb carbon monoxide (CO) at room temperature. The use of N-heterocyclic carbene ligands with hemi-labile N-phosphine oxide substituents facilitates both the adsorption and desorption of CO on nickel(0) via ligand substitution. Ionic liquids were used as the reaction medium to enhance the desorption rate and establish a reusable system. These results showcase a way for the sustainable chemisorption of CO using a zero-valent transition-metal complex.Yamauchi Y., Hoshimoto Y., Kawakita T., et al. Room-Temperature Reversible Chemisorption of Carbon Monoxide on Nickel(0) Complexes. Journal of the American Chemical Society , (2022); https://doi.org/10.1021/jacs.2c02870

Reversible Modulation of the Electronic and Spatial Environment around Ni(0) Centers Bearing Multifunctional Carbene Ligands with Triarylaluminum

Designing and modulating the electronic and spatial environments surrounding metal centers is a crucial issue in a wide range of chemistry fields that use organometallic compounds. Herein, we demonstrate a Lewis-acid-mediated reversible expansion, contraction, and transformation of the spatial environment surrounding nickel(0) centers that bear N-phosphine oxide-substituted N-heterocyclic carbenes (henceforth referred to as (S)PoxIms). Reaction between tetrahedral (syn-κ-C,O-(S)PoxIm)Ni(CO)2 and Al(C6F5)3 smoothly afforded heterobimetallic Ni/Al species such as trigonal-planar {κ-C-Ni(CO)2}(μ-anti-(S)PoxIm){κ-O-Al(C6F5)3} via a complexation-induced rotation of the N-phosphine oxide moieties, while the addition of 4-dimethylaminopyridine resulted in the quantitative regeneration of the former Ni complexes. The corresponding interconversion also occurred between (SPoxIm)Ni(η2:η2-diphenyldivinylsilane) and {κ-C-Ni(η2:η2-diene)}(μ-anti-SPoxIm){κ-O-Al(C6F5)3} via the coordination and dissociation of Al(C6F5)3. The shape and size of the space around the Ni(0) center was drastically changed through this Lewis-acid-mediated interconversion. Moreover, the multinuclear NMR, IR, and XAS analyses of the aforementioned carbonyl complexes clarified the details of the changes in the electronic states on the Ni centers; i.e., the electron delocalization was effectively enhanced among the Ni atom and CO ligands in the heterobimetallic Ni/Al species. The results presented in this work thus provide a strategy for reversibly modulating both the electronic and spatial environment of organometallic complexes, in addition to the well-accepted Lewis-base-mediated ligand-substitution methods.Yamauchi Y., Mondori Y., Uetake Y., et al. Reversible Modulation of the Electronic and Spatial Environment around Ni(0) Centers Bearing Multifunctional Carbene Ligands with Triarylaluminum. Journal of the American Chemical Society 145, 16938 (2023); https://doi.org/10.1021/jacs.3c06267

Some Relations between Watson-Crick Finite Automata and Chomsky Hierarchy

Watson-Crick automata, recently introduced in [1], are new types of automata in the DNA computing framework, working on tapes which are double stranded sequences of symbols related by a complementarity relation, similar to a DNA molecule. The automata scan separately each of the two strands in a corelated mannar. Some restricted variants of them were also introduced and the relationship between the families of languages recognized by them were investigated in [1]-[4]. In this paper, we clarify some relations between the families of languages recognized by the restricted variants of Watson-Crick finite automata and the families in the Chomsky hierarchy

Complexation-Induced N‒P Axial Chirality in Sm(II) N-Phosphine-Oxide-Substituted Imidazolylidene and Imidazolinylidene Complexes

Two types of Sm(II) complexes bearing either an N-phosphine-oxide-substituted imidazolylidene (PoxIm) or the corresponding imidazolinylidene (SPoxIm) were successfully prepared and characterized using single crystal X-ray diffraction analysis. The general formula of the structures of the complexes was found to be (anti-k-O-(S)PoxIm)nSmX2(THF)m where X = I, n = 2, m = 2 or X = pentamethylcyclopentadienyl, n = 1, m = 0. The carbene carbon atoms remained intact in these complexes. In some cases, axial chirality was clearly induced around the N‒P bonds due to the restricted rotation of the N-phosphinoyl moieties, which arises from the formation of N-phosphinoyl oxygen‒Sm(II) bonds. This work highlights a rare example of complexation-induced N‒P axial chirality and new aspects regarding lanthanide complexes of multifunctional multipurpose carbenes

<症例>Tamoxifen 併用多剤化学療法 (5-Fluorouracil, Epirubicin, Cyclophosphamide) が著効を示した進行男性乳癌の1例

A 79-year old male advanced breast cancer patient with metastases in lymph nodes, bones and anterior chest wall was effectively treated by a combination of chemotherapy (5-fluorouracil, epirubicin and cyclophosphamide), tamoxifen and minor surgery. Two months after five cycles of chemotherapy, all lymph node swellings disappeared. The main breast cancer and the chest wall metastatic nodule were resected under local anesthesia. He was maintained on tamoxifen alone and showed no lymph node recurrence during the follow up period of 20 months, suggesting good control of bone metastatic lesions.多発性鎖骨上寓, 腋窩リンパ節転移, 多発性骨転移, 胸壁転移を有する79歳男性進行乳癌症例に対し, 胸壁転移巣切除生検にて Estrogen 受容体陽性を確認したのち, Tamoxifen 併用多剤化学療法 (5-Fluorouracil, Epirubicin, Cyclophosphamide) を施行した. 化学療法5回終了後約2ヶ月ですべてのリンパ節腫脹の消失をみたため, 外来にて単純乳房切断術をおこなった. 以後 Tamoxifen のみの投与にて外来で追跡し, 化学療法終了後約20ヶ月間リンパ節再発を認めず, 骨転移巣も良好に制御された現在, 患者は全く愁訴なく元気に日常生活を送っている. 小手術と組み合わせた Tamoxifen 併用多剤化学療法が著効を示した男性進行乳癌の1例を報告した