The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review

Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended in humans. Here we present a brief review of the information availabile regarding the pharmacokinetics and interactions of ivermectin in humans. Awareness of these characteristics could improve the clinical efficacy of Ivermectin. All Authors declare that they do not have any Conflict of interest and that the work is original. All Authors agree that the contents of the manuscript are confidential and will not be copyrighted, submitted, or published elsewhere (including the Internet), in any language, while acceptance by the Journal is under consideration

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Unconventional Composite Feed Ingredients on Storage and Sensory Attributes of Chicken Meat

Aim: The present study investigated the effect of unconventional (Carica papaya,&nbsp;Manihot esculenta leaf&nbsp;and&nbsp;Brassica oleracea var. capitata&nbsp;leaves) Composite Feed Ingredients on storage and sensory attributes of chicken meat. Study Design: Quasi Experimental Place and Duration of Study: Department of Animal Production and Health Technology, Department of Nutrition and Dietetics and Department of Science Laboratory Technology, Imo State Polytechnic Umuagwo-Ohaji, June 2020-April, 2021. &nbsp;Methodology: Arbor Acres broiler reared with unconventional composite feed ingredients, consisting of 0%, 2.5%, 5%, 7.5% proportions of Homogenized Vegetable Meal (HVM) was used. After six weeks, the broilers were slaughtered, cleaned and stored in the freezer at the temperature of 30C. Nutrient Agar (NA), Mac Conkey Agar (MCA) and Sabouraud Dextrose Agar (SDA) were the media used for the determination of bacterial and fungi growth on chicken meats during storage. Sensory evaluation of chicken meats was determined after 14 days of storage. Results: The result revealed low (3.4x 105-8x105) microbial and fungi (2.1 x105-7 x105) growth on the chicken meat samples. There was no significant difference (P=0.05) in the sensory attributes (taste, colour, aroma and general acceptability) tested. The chicken meats were generally (7.6 -7.8) acceptable by the taste panel members after 14 days of storage. Conclusion: The inclusion of unconventional (leave) ingredients in broiler feed did not affect the storage of chicken meat, rather some sensory attributes (aroma and colour) of chicken meat were improved

Crisp-dm/smes: A data analytics methodology for non-profit smes

The exponential increase in information due to technological advances and the development of communications has created the need to make decisions based on the data analysis. This trend has opened the doors to new approaches to data understanding and decision-making. On the one hand, companies need to follow data analytic methodologies to manage large volumes of information with big data tools. On the other hand, there are non-profit small and medium-sized enterprises (SMEs) that make efforts to address data analytics according to their different sources and types. They find challenges such as lack of knowledge in methodological and software tools, which allow timely deployment for decision-making. In this paper, we propose a data analytics methodology for non-profit SMEs. The design of this methodology is based on CRISP-DM as a reference framework, is represented by Software Process Engineering Metamodel (SPEM) and is characterized by being simple, flexible, and low implementation costs. © Springer Nature Singapore Pte Ltd. 2020

Three cases of prune belly syndrome at the Lagos State University Teaching Hospital, Ikeja

Prune belly syndrome (PBS) is a rare congenital disorder affecting 2.5 to 3.8/100,000 live births worldwide. Our objective of this report is to describe clinical manifestation, laboratory, and radiological characteristics of PBS in our patients, to highlight the limitations to offering appropriate patient care due to parents demanding discharge against medical advice and the need to increase the awareness regarding this rare disease. We report three cases; all referred after birth with lax abdominal wall, congenital anomalies of kidney, and urinary tract. One of the patients had an absent right foot. They all had cryptorchidism, and in one, there was deranged renal function. The reported cases had both medical and radiological interventions to varying degrees. They all had an abdominal ultrasound which revealed varying degrees of hydronephrosis, hydroureters, and bladder changes. Voiding cystourethrogram showed vesicoureteric reflux in one of the reported cases. Urinary tract infections were appropriately treated with antibiotics based on sensitivity. PBS management in our setting remains a challenge because of strong cultural beliefs, and high rate of discharge against medical advice. Focus should be on parent education, early diagnosis, and multidisciplinary management approach

Comparing the Neuroprotective Effects of Aqueous and Methanolic Extracts of Vernonia Amygdalina on the Cerebellum of Adult Male Wistar Rats

The solvent of extraction determines the type and amount of phytochemicals extractible from a plant material. Reports have shown that numerous African herbs are rich is potent phytochemicals which have been used in folkloric and orthodox medicine in the prevention and treatment of ailments. This research is geared towards comparing the neuroprotective potency of the aqueous and methanolic extracts of Vernonia amygdalina on the cerebellum of mercury chloride intoxicated Wistar rats. Thirty adult male Wistar rats were divided into 6 groups of 5 rats each. Group A was the negative control and had food and water only. Group B was the positive control and was exposed to mercury chloride without treatment. Groups C1 and C2 received 200mg/kg bw of aqueous and methanolic extracts respectively while groups D1 and D2 received 400mg/kg bw of aqueous and methanolic extracts of Vernonia amygdalina respectively. Result of phytochemical analysis shows that water extracted more flavonoids while methanol extracted more phenols. The results of antioxidant studies show that the methanolic extract conferred more protection against oxidative stress than the aqueous extract. Histological results show that aqueous extract conferred more protection than the methanolic extract. We therefore conclude from our report that both the aqueous and methanolic extracts of Vernonia amygdalina confer neuroprotection on the cerebellum of Wistar rats