Phylogenetic analyses of Japanese golden chanterelles and a new species description, Cantharellus anzutake sp nov.

ArticleMycoscience. 59(2): 153-165. (2018)journal articl

In vitro ectomycorrhization of Tricholoma matsutake strains is differentially affected by soil type.

ArticleMycoscience. 59(1): 89-97. (2018)journal articl

Efficient establishment of pure cultures of yellow chanterelle Cantharellus anzutake from ectomycorrhizal root tips, and morphological characteristics of ectomycorrhizae and cultured mycelium

ArticleMycoscience. 60(1): 45-53. (2019)journal articl

Processes of sustentation and collapse of algal aggregations of the Marimo (Aegagropila linnaei) in Lake Akan, Japan, and Lake Mývatn, Iceland

第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月27日（火） 国立極地研究所 ３階ラウン

B cell-derived GABA elicits IL-10⁺ macrophages to limit anti-tumour immunity

GABAを標的とする抗腫瘍免疫機構 --代謝産物を介した免疫細胞間制御の一端を解明--. 京都大学プレスリリース. 2021-11-10.Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu1-3. Here we identify the metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized and secreted by activated B cells and plasma cells. We show that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages that secrete interleukin-10 and inhibit CD8⁺ T cell killer function. In mice, B cell deficiency or B cell-specific inactivation of the GABA-generating enzyme GAD67 enhances anti-tumour responses. Our study reveals that, in addition to cytokines and membrane proteins, small metabolites derived from B-lineage cells have immunoregulatory functions, which may be pharmaceutical targets allowing fine-tuning of immune responses

Comparison the micro-ecosystem of aggregates of microorganisms in Antarctic Lake, Skallen Ôike with algal aggregations of the Marimo (Aegagropila linnaei) in Lake Akan, Japan.

第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月27日（火） 国立極地研究所 ３階ラウン

Effects of Clenbuterol, a β2-Adrenergic Agonist, on Sizes of Masseter, Temporalis, Digastric, and Tongue muscles

We compared the hypertrophic effects of clenbuterol, a β2-adrenergic agonist, on the masseter, digastric, and temporalis with those on the tongue, tibialis anterior, soleus, diaphragm, and heart. The weights of masseter, digastric and temporalis in the clenbuterol group were 36 ~ 56% greater than those in the control group, whereas those of the tibialis anterior, diaphragm, and heart weights in the clenbuterol group were 9 ~ 33% greater than those in the control group. No significant difference in the weights of the soleus and tongue was found between the control and clenbuterol groups. Taken together with our present and previously reported results, it is suggested that the hypertrophic effects of clenbuterol on the masseter, digastric, and temporalis are greater than those on the limb, trunk, and heart

Pigment analyses of Antarctic Marimo and other algae

第2回極域科学シンポジウム/第33回極域生物シンポジウム 11月18日（金） 統計数理研究所 3階リフレッシュフロ

Evolution and adaptation of living in the extreme environments 2012 Photoresponse of algae and Antarctic MARIMO

第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月27日（火） 国立極地研究所 ３階ラウン

[11C]phosgene: Synthesis and application for development of PET radiotracers

Carbon-11-labeled phosgene ([11C]phosgene, [11C]COCl2) is a useful labeling agent that connects two heteroatoms by inserting [11C]carbonyl (11C=O) function in carbamates, ureas, and carbonates, which are components of biologically important heterocyclic compounds and functional groups in drugs as a linker of fragments with in vivo stability. Development of 11C-labeled PET tracers has been performed using [11C]phosgene as a labeling agent. However, [11C]phosgene has not been frequently used for 11C-labeling because preparation of [11C]phosgene required dedicated synthesis apparatus (not commercially available) and had problems in reproducibility and reliability. In our laboratory, an improved method for synthesizing [11C]phosgene using a carbon tetrachloride detection tube kit in environmental air analysis and the automated synthesis system for preparing [11C]phosgene have been developed in 2009. This apparatus has been used for routine synthesis of 11C-labeled tracers 1–4 times/week. Using [11C]phosgene we have developed and produced many PET radiotracers containing [11C]urea and [11C]carbamate moieties. In this review, we report the performance of our method for preparing [11C]phosgene, including automated synthesis apparatus developed in house, and the application of [11C]phosgene for development and production of 11C-labeled PET tracers