A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression

The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the immune system, and (ii) to perform a prediction analysis of regulatory network hubs that might serve as potential biomarkers during stress-induced immunosuppression. Several literature and bioinformatics databases/repositories were utilized to review Fe metabolism and complement the molecular description of prioritized proteins. The Search Tool for the Retrieval of Interacting Genes (STRING) was used to build a protein-protein interactions network for subsequent network topology analysis. Importantly, Fe is a sensitive double-edged sword where two extremes of its nutritional status may have harmful effects on innate and adaptive immunity. We identified clearly connected important hubs that belong to two clusters: (i) presentation of peptide antigens to the immune system with the involvement of redox reactions of Fe, heme, and Fe trafficking/transport; and (ii) ubiquitination, endocytosis, and degradation processes of proteins related to Fe metabolism in immune cells (e.g., macrophages). The identified potential biomarkers were in agreement with the current experimental evidence, are included in several immunological/biomarkers databases, and/or are emerging genetic markers for different stressful conditions. Although further validation is warranted, this hybrid method (human-machine collaboration) to extract meaningful biological applications using available data in literature and bioinformatics tools should be highlighted.The ‘Bioinformatics-assisted Review’ is a project developed and supported by the Research Division at the Dynamical Business and Science Society—DBSS International SAS. The APC was funded by the Exercise & Sport Nutrition Laboratory (ESNL) at Texas A&M University, the POWER LAB at University of Central Florida and the Sport Genomics Research Group at University of the Basque Country UPV/EHU

Implicaciones del porte legal de armas en salud pública: Una mirada desde el caso colombiano

La Organización Mundial de la Salud (OMS) define la violencia como el uso de la fuerza física de manera exagerada contra sí mismos o con miembros de una comunidad. Cada acto de violencia en sí, genera un aumento del riesgo de muerte, de esta manera, se estima que 9 de cada 10 muertes violentas no se encuentra asociada al conflicto armado. &nbsp

Expedición cangrejo negro : informe técnico

El huracán Iota que pasó por las islas de providencia y Santa catalina el 16 de noviembre de 2020 produjo efectos importantes en los ecosistemas de las islas, así como en los servicios que estos ofrecen a las comunidades locales y que dan lugar a un atractivo turístico que se constituye en la principal actividad económica de las islas. Este trabajo corresponde a un esfuerzo por identificar áreas importantes para la prestación de los servicios ecosistémicos (SSE) en especial aquellas que pudieron haber resultado especialmente afectadas como resultado de Iota, para tal fin se aborda un enfoque basado en el análisis de datos geoespaciales, apoyado por la consulta de información secundaria. La revisión de la información secundaria permitió identificar SSE relevantes en la isla fundamentalmente relacionados con protección frente a desastres naturales y servicios de provisión y regulación hídrica, mientras que los análisis espaciales permitieron identificar cuencas importantes frente a estos servicios como Freshwater, Bailey, Bowden y Santa Catalina Sur, los análisis de imágenes satelitales por su parte permitieron identificar áreas afectadas por la pérdida de vegetación y acumulación de biomasa.Bogot

Amplified Genes May Be Overexpressed, Unchanged, or Downregulated in Cervical Cancer Cell Lines

Several copy number-altered regions (CNAs) have been identified in the genome of cervical cancer, notably, amplifications of 3q and 5p. However, the contribution of copy-number alterations to cervical carcinogenesis is unresolved because genome-wide there exists a lack of correlation between copy-number alterations and gene expression. In this study, we investigated whether CNAs in the cell lines CaLo, CaSki, HeLa, and SiHa were associated with changes in gene expression. On average, 19.2% of the cell-line genomes had CNAs. However, only 2.4% comprised minimal recurrent regions (MRRs) common to all the cell lines. Whereas 3q had limited common gains (13%), 5p was entirely duplicated recurrently. Genome-wide, only 15.6% of genes located in CNAs changed gene expression; in contrast, the rate in MRRs was up to 3 times this. Chr 5p was confirmed entirely amplified by FISH; however, maximum 33.5% of the explored genes in 5p were deregulated. In 3q, this rate was 13.4%. Even in 3q26, which had 5 MRRs and 38.7% recurrently gained SNPs, the rate was only 15.1%. Interestingly, up to 19% of deregulated genes in 5p and 73% in 3q26 were downregulated, suggesting additional factors were involved in gene repression. The deregulated genes in 3q and 5p occurred in clusters, suggesting local chromatin factors may also influence gene expression. In regions amplified discontinuously, downregulated genes increased steadily as the number of amplified SNPs increased (p<0.01, Spearman's correlation). Therefore, partial gene amplification may function in silencing gene expression. Additional genes in 1q, 3q and 5p could be involved in cervical carcinogenesis, specifically in apoptosis. These include PARP1 in 1q, TNFSF10 and ECT2 in 3q and CLPTM1L, AHRR, PDCD6, and DAP in 5p. Overall, gene expression and copy-number profiles reveal factors other than gene dosage, like epigenetic or chromatin domains, may influence gene expression within the entirely amplified genome segments

Miradas desde la historia social y la historia intelectual: América Latina en sus culturas: de los procesos independistas a la globalización

Fil: Benito Moya, Silvano G. A. Universidad Católica de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Universidad Católica de Córdoba. Facultad de Filosofía y Humanidades; Argentina

400 años de Don Quijote: actualidad y enseñanza. Programa Diálogos del Pensamiento 180

Una obra de arte es clásica porque trasciende su época y perdura en el transcurso de los años. Lo que la hace trascender es que revela desde lo más profundo de su expresión la naturaleza y la condición humana: le dice al hombre universal lo que es, lo que siente, lo que vive, lo que anhela y comparte por el sólo hecho de ser humano. Y éste es precisamente el caso de Don Quijote de la Mancha, la máxima obra de la literatura española universal. En pleno siglo XXI, en el año 2015, a 400 años de la publicación de El ingenioso hidalgo Don Quijote de la Mancha, en toda asignatura escolar literaria -desde la educación básica hasta la educación superior y los estudios especializados de posgrado-, ésta es una obra de referencia obligada para su lectura, reflexión, aprendizaje y discusión. Pero enseñar el Quijote no es obra fácil. En esta emisión platicamos sobre esto con el Maestro Juan Manuel Sánchez Ocampo ¿Cómo nos debemos acercar pues a la obra para obtener el mayor provecho posible? ¿Con qué recursos contamos en plena era digital, para llevarla a niños, jóvenes y adultos

¿Estamos observando un número creciente de coinfecciones entre el SARS-CoV-2 y otros patógenos respiratorios?

We have recently read the article by Chaung et al1 describing a case of SARS‐CoV‐2 and HCoV‐HKU1 coinfection. The HCoV‐HKU1 is also a member of the Betacoronavirus. In addition to other coronaviruses in different regions of the world, there is an increasing number of reports of coinfections in SARS‐CoV‐2/COVID‐19. Then, we would like to take the opportunity to discuss some of them,1-10 as there are not yet reviews on this emerging issue of COVID‐19. Currently, the evidence suggests that the coinfection rates between SARS‐CoV‐2 and other respiratory pathogens would be higher than initially expected, which represents a challenge for the diagnosis and treatment