Antimicrobial activity of the ethanol extract of the aerial parts of sida acuta burm.f. (malvaceae)

Purpose: The antimicrobial activity of the 90 % ethanol extract of the aerial parts of Sida acuta Burm. F. (Malvaceae) was investigated in other to verify its claimed ethno medicinal use in the treatment of microbial infections. Method: The antimicrobial activity of the extract was tested against standard strains and clinical isolates of some aerobic bacteria and a fungus using the Agar well diffusion method. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains. Results: The extracts showed significant inhibitory activity against standard strains and clinical isolates of Staphylococcus aureus, clinical isolates of Bacillus subtilis and Streptococcus faecalis. The MIC values obtained using the Agar-dilution test ranged from 5.0 mg/ml. – 10.0 mg/ml. Neither the concentrated extract nor its dilutions inhibited Esherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Candida albicans Conclusion: The results demonstrate that the crude extract of the aerial parts of Sida acuta has a narrow spectrum of activity and suggest that it may be useful in the treatment of infections caused by Gram positive aerobic bacteria. Keywords: Sida acuta, ethanol extract, antimicrobial activity. Tropical Journal of Pharmaceutical Research Vol. 6 (4) 2007: pp. 809-81

Enhancing the Effectiveness of Vertical Water Injection Wells With Inflow Control Devices (ICDs): Design, Simulation and Economics

Water injector completion techniques used traditionally, such as frac packs or openhole standalone screens, were judged to be incapable of meeting all completion objectives and have been reported to loose injectivity over time coupled with the issue of long term injection conformance due to plugging. Another major challenge is to achieve even distribution of the injected water into all zones along the wellbore. Permeability contrasts, formation damage, creation of thief fractures, and changes in wellbore injectivity need to be managed to avoid early breakthrough in adjacent production wells. This study presents the application of inflow control devices (ICDs), fined tuned by reservoir simulations for balancing the water injection profile into various sand formation zones in an open–hole completed injector well in Flo-Z6, a stratified Niger Delta reservoir with communicating layers.The solution targeted at developing a screening tool for deciding candidate layers in Flo-Z6 reservoir and installing special flow control devices, tailor-made for injection wells and with correct nozzle sizes for this particular case.The results from this study show that, the installation of ICDs with different nozzle configuration in the injector wells tailored to equalize the water outflow (for better sweep efficiency), improved the field oil recovery by 11.9% (6.6MMstb). Economic indicators used to validate the profitability of the investment further showed that completing the injectors with different ICD nozzle configuration was more profitable, with an NPV@10% of $192.5million, profit per dollar invested of$6.6, DCF-ROR of 81% and a pay-out period of 1.2 year which is relatively short

Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice

The X-linked gene STS encodes the steroid hormone-modulating enzyme steroid sulfatase. Loss-of-function of STS, and variation within the gene, have been associated with vulnerability to developing attention deficit hyperactivity disorder (ADHD), a neurodevelopmental condition characterized by inattention, severe impulsivity, hyperactivity, and motivational deficits. ADHD is commonly comorbid with a variety of disorders, including obsessive–compulsive disorder. The neurobiological role of steroid sulfatase, and therefore its potential role in ADHD and associated comorbidities, is currently poorly understood. The 39,XY*O mouse, which lacks the Sts gene, exhibits several behavioral abnormalities relevant to ADHD including inattention and hyperactivity. Here, we show that, unexpectedly, 39,XY*O mice achieve higher ratios than wild-type mice on a progressive ratio (PR) task thought to index motivation, but that there is no difference between the two groups on a behavioral task thought to index compulsivity (marble burying). High performance liquid chromatography analysis of monoamine levels in wild type and 39,XY*O brain tissue regions (the frontal cortex, striatum, thalamus, hippocampus, and cerebellum) revealed significantly higher levels of 5-hydroxytryptamine (5-HT) in the striatum and hippocampus of 39,XY*O mice. Significant correlations between hippocampal 5-HT levels and PR performance, and between striatal 5-HT levels and locomotor activity strongly implicate regionally-specific perturbations of the 5-HT system as a neurobiological candidate for behavioral differences between 40,XY and 39,XY*O mice. These data suggest that inactivating mutations and functional variants within STS might exert their influence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic system